Diagenode

Where stem cell studies & epigenetics research finally meet

 

CRISPR/Cas 9 antibody

Validated for immunoblot, IP, and IF

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In recent years, studies suggest that the mammalian genome undergoes various epigenetic modifications during development and embryonic stem cell (ESC) differentiation. Understanding the mechanisms that control these epigenetic signals is essential in deciphering stem cell biology and the patterns of gene expression during cellular differentiation. ESC gene expression relies heavily on transcriptional factor networks and epigenetic signals that give stem cells their ability to differentiate into different cell types -- histone modification, histone variants, and DNA methylation. Diagenode provides a full solution for your every epigenetics and stem cell research need including ChIP and ChIP-seq antibodies and kits for low cell amounts, DNA methylation kits and antibodies, and sample processing instruments.

 


Products for epigenetics studies in stem cell research

ChIP and ChIP-seq kits to decipher the epigenetic landscape of stem cells

DNA methylation kits for sensitive, fast, and NGS-compatible studies

Antibodies for ChIP, ChIP-seq, histone modifications, DNA methylation, hydroxymethylation, and more

Sample prep and processing


References

Santourlidis S, Wernet P, Ghanjati F, Graffmann N, Springer J, Kriegs C, Zhao X, Brands J, Araúzo-Bravo MJ, Neves R, Koegler G, Uhrberg M, Unrestricted somatic stem cells (USSC) from human umbilical cord blood display uncommitted epigenetic signatures of the major stem cell pluripotency genes., Stem Cell Res,2011-01-01,6,60-9, Abstract

Williams K, Christensen J, Pedersen MT, Johansen JV, Cloos PA, Rappsilber J, Helin K, TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity., Nature,2011-05-19,473,343-8, Abstract

Iliou MS, Lujambio A, Portela A, Brüstle O, Koch P, Andersson-Vincent PH, Sundström E, Hovatta O, Esteller M Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer., Epigenetics,2011-11-01,6,1344-53, Abstract

Singhal N, Graumann J, Wu G, Araúzo-Bravo MJ, Han DW, Greber B, Gentile L, Mann M, Schöler HR, Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming., Cell,2010-06-11,141,943-55, Abstract

Wang K, Chen Y, Chang EA, Knott JG, Cibelli JB., Dynamic Epigenetic Regulation of the Oct4 and Nanog Regulatory Regions during Neural Differentiation in Rhesus Nuclear Transfer Embryonic Stem Cells., Cloning Stem Cells.,2009-12,11,483-96, Abstract

Grandjean V, Gounon P, Wagner N, Martin L, Wagner KD, Bernex F, Cuzin F, Rassoulzadegan M, The miR-124-Sox9 paramutation: RNA-mediated epigenetic control of embryonic and adult growth., Development,2009-11-01,136,3647-55, Abstract

Noer A, Lindeman LC, Collas P, Histone H3 modifications associated with differentiation and long-term culture of mesenchymal adipose stem cells., Stem Cells Dev,2009-06-01,18,725-36, Abstract

Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AG, ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency., Cell Stem Cell,2010-06-04,6,547-56, Abstract

Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, Arnaud P, Pombo A, O'Neill L, Azuara V, Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment., Development,2010-08-01,137,2483-92, Abstract

Sher F, Boddeke E, Olah M, Copray S, Dynamic Changes in Ezh2 Gene Occupancy Underlie Its Involvement in Neural Stem Cell Self-Renewal and Differentiation towards Oligodendrocytes, PLoS ONE,2012-07-12, Abstract

Ruzov A, Tsenkina Y, Serio A, Dudnakova T, Fletcher J, Bai Y, Chebotareva T, Pells S, Hannoun Z, Sullivan G, Chandran S, Hay DC, Bradley M, Wilmut I, De Sousa P, Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development., Cell Res,2011-09-01,21,1332-42, Abstract

Stroud H, Feng S, Morey Kinney S, Pradhan S, Jacobsen SE, 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells., Genome Biol,2011-06-20,12,R54, Abstract

Wu H, D'Alessio AC, Ito S, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y, Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells., Genes Dev,2011-04-01,25,679-84, Abstract

Boulland JL, Mastrangelopoulou M, Boquest AC, Jakobsen R, Noer A, Glover JC, Collas P., Epigenetic Regulation of Nestin Expression During Neurogenic Differentiation of Adipose Tissue Stem Cells., Stem Cells Dev.,2012-12-21, Abstract

Marks H, Kalkan T, Menafra R, Denissov S, Jones K, Hofemeister H, Nichols J, Kranz A, Francis Stewart A, Smith A, Stunnenberg HG, The transcriptional and epigenomic foundations of ground state pluripotency., Cell,2012-04-27,149,590-604, Abstract

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