DNA demethylation triggers cell free DNA release in colorectal cancer cells Published: October, 2024 Abstract:
Background
Liquid biopsy based on cell-free DNA (cfDNA) analysis holds significant promise as a minimally invasive approach for the diagnosis, genotyping, and monitoring of solid malignancies. Human tumors release cfDNA in the bloodstream through... Read more »
Transient loss of Polycomb components induces an epigenetic cancer fate Published: April, 2024 Abstract:
Although cancer initiation and progression are generally associated with the accumulation of somatic mutations1,2, substantial epigenomic alterations underlie many aspects of tumorigenesis and cancer susceptibility3,4,5,6, suggesting that genetic ... Read more »
In vitro production of cat-restricted Toxoplasma pre-sexual stages Published: December, 2023 Abstract:
Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely uncharted owing to ethical concerns regarding the use of cats as model organisms. Chromatin modifiers dictate the developmental fate of the parasite during i... Read more »
Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates Published: May, 2023 Abstract:
The compaction of chromatin is a prevalent paradigm in gene repression. Chromatin compaction is commonly thought to repress transcription by restricting chromatin accessibility. However, the spatial organisation and dynamics of chromatin compacted... Read more »
