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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive ge...
Published: November, 2024
Abstract: Highlights Degradation of NUP98-fp halts nascent transcription of key oncogenes within 1 h NUP98-fp loss results in accumulat... Read more »
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Antibody
HIRA protects telomeres against R-loop-induced instability in ALT c...
Published: November, 2024
Abstract: Highlights HIRA establishes greater telomeric chromatin accessibility after ATRX-DAXX loss Deposition of new H3.3 by HIRA-UBN r... Read more »
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Tagmentase
Claudin-1 as a potential marker of stress-induced premature senesce...
Published: November, 2024
Abstract: Cellular senescence, a permanent state of cell cycle arrest, can result either from external stress and is then called stress-induced premature sen... Read more »
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Antibody iDeal ChIP-seq Kit for Histones
Engineered PsCas9 enables therapeutic genome editing in mouse liver...
Published: November, 2024
Abstract: Clinical implementation of therapeutic genome editing relies on efficient in vivo delivery and the safety of CRISPR-Cas tools. Previously, we ident... Read more »
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Tagmentase
ACE2 Enhances Sensitivity to PD-L1 Blockade by Inhibiting Macrophag...
Published: November, 2024
Abstract: Anti-PD-L1-based combination immunotherapy has become the first-line treatment for unresectable hepatocellular carcinoma (HCC). However, the object... Read more »
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Microplex Library Preparation kit
The molecular consequences of FOXF1 missense mutations associated w...
Published: November, 2024
Abstract: Background Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a fatal congenital lung disorder strongly associated wit... Read more »
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CUT&Tag
Atypical chemokine receptor 2 expression is directly regulated by h...
Published: November, 2024
Abstract: Lack of significant and durable clinical benefit from anti-cancer immunotherapies is partly due to the failure of cytotoxic immune cells to infiltr... Read more »
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iDeal ChIP-qPCR
ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fa...
Published: November, 2024
Abstract: SREBF1 plays the central role in lipid metabolism. It has been known that full-length SREBF1 that did not associate with SCAP (SCAP-free SREBF1) is... Read more »
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Tagmentase
Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticit...
Published: October, 2024
Abstract: Cancer cell plasticity contributes significantly to the failure of chemo- and targeted therapies in triple-negative breast cancer (TNBC). Molecular... Read more »
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iDeal ChIP-seq Kit for Transcription Factors
A multidimensional recommendation framework for identifying biologi...
Published: October, 2024
Abstract: The quest to understand the molecular mechanisms of tumour metastasis and identify pivotal biomarkers for cancer therapy is increasing in importanc... Read more »
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Antibody
GTSF1 is required for transposon silencing in the unicellular eukar...
Published: October, 2024
Abstract: The PIWI-interacting RNA (piRNA) pathway is crucial for transposon repression and the maintenance of genomic integrity. Gametocyte-specific factor ... Read more »
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Antibody
Extracellular vesicle-mediated trafficking of molecular cues during...
Published: October, 2024
Abstract: Cellular crosstalk is an essential process influenced by numerous factors, including secreted vesicles that transfer nucleic acids, lipids, and pro... Read more »
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Microplex Library Preparation kit
COL25A1 and METAP1D DNA methylation are promising liquid biopsy epi...
Published: October, 2024
Abstract: Background Colorectal cancer is a public health issue and was the third leading cause of cancer-related death worldwide in 2022. Early diagnosis c... Read more »
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Premium Bisulfite Kit
Differential methylation of circulating free DNA assessed through c...
Published: October, 2024
Abstract: Background Recent studies have highlighted the importance of the cell-free DNA (cfDNA) methylation profile in detecting breast cancer (BC) and its... Read more »
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MagMeDIP kit
Dysregulation of pseudouridylation in small RNAs contributes to pap...
Published: October, 2024
Abstract: Background Previous studies have indicated that ψ-modified small RNAs play crucial roles in tumor metastasis. However, the ψ-modified smal... Read more »
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Antibody
Biochemical characterization of the feedforward loop between CDK1 a...
Published: October, 2024
Abstract: The complex network governing self-renewal in epidermal stem cells (EPSCs) is only partially defined. FOXM1 is one of the main players in this netw... Read more »
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iDeal ChIP-seq Kit for Transcription Factors
Epigenetic Analysis of ST3GAL3 and other Sialic Acid Metabolism Gen...
Published: October, 2024
Abstract: Research indicates that the underlying neurobiology of Attention Deficit/Hyperactivity Disorder (ADHD) may stem from a combination of genetic and e... Read more »
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Infinium Human MethylationEPIC Array Service
DNA demethylation triggers cell free DNA release in colorectal canc...
Published: October, 2024
Abstract: Background Liquid biopsy based on cell-free DNA (cfDNA) analysis holds significant promise as a minimally invasive approach for the diagnosis, gen... Read more »
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ATAC-seq
Multi-omics characterization of chronic social defeat stress recall...
Published: October, 2024
Abstract: Susceptibility to chronic social stressors often results in the development of mental health disorders including major depressive and anxiety disor... Read more »
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Premium RRBS Kit
Prediction of brain metastasis development with DNA methylation sig...
Published: October, 2024
Abstract: Brain metastases (BMs) are the most common and among the deadliest brain tumors. Currently, there are no reliable predictors of BM development from... Read more »
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MagMeDIP kit IPure kit
The small inhibitor WM-1119 effectively targets KAT6A-rearranged AM...
Published: October, 2024
Abstract: Background The epigenetic factors KAT6A (MOZ/MYST3) and KMT2A (MLL/MLL1) interact in normal hematopoiesis to regulate progenitors’ self-rene... Read more »
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Antibody Microplex Library Preparation kit
Integrated multi-omics analysis of PBX1 in mouse adult neural stem-...
Published: October, 2024
Abstract: Developmental transcription factors act in networks, but how these networks achieve cell- and tissue specificity is still poorly understood. Here, ... Read more »
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Antibody Microplex Library Preparation kit
HNF1β bookmarking involves Topoisomerase 1 activation and DNA topol...
Published: October, 2024
Abstract: Highlights HNF1β mitotic site binding is preserved with a specific methanol/formaldehyde ChIP BTBD2, an HNF1β partner... Read more »
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IPure kit Microplex Library Preparation kit Tagmentase
Pesticide-induced transgenerational alterations of genome-wide DNA ...
Published: October, 2024
Abstract: The unsustainable use of manmade chemicals poses significant threats to biodiversity and human health. Emerging evidence highlights the potential o... Read more »
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Premium RRBS Kit
5-Hydroxymethylcytosine in circulating cell-free DNA as a potential...
Published: October, 2024
Abstract: Background SLE is a complex autoimmune disease with heterogeneous manifestations and unpredictable outcomes. Early diagnosis is challenging ... Read more »
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Antibody
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogen...
Published: October, 2024
Abstract: Mutation of tet methylcytosine dioxygenase 2 (encoded by TET2) drives myeloid malignancy initiation and progression1,2,3. TET2 deficiency is k... Read more »
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Antibody
RNA polymerase II transcription initiation in holo-TFIID-depleted m...
Published: September, 2024
Abstract: The recognition of core promoter sequences by TFIID is the first step in RNA polymerase II (Pol II) transcription initiation. Metazoan holo-TFIID i... Read more »
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Microplex Library Preparation kit
Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling
Published: September, 2024
Abstract: Trained immunity is characterized by histone modifications and metabolic changes in innate immune cells following exposure to inflammatory signals,... Read more »
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Antibody
Legionella pneumophila modulates macrophage functions through epige...
Published: September, 2024
Abstract: Legionella pneumophila is a pathogen which can lead to a severe form of pneumonia in humans known as Legionnaires disease after replication in... Read more »
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Antibody
Two-factor authentication underpins the precision of the piRNA pathway
Published: September, 2024
Abstract: The PIWI-interacting RNA (piRNA) pathway guides the DNA methylation of young, active transposons during germline development in male mice. piRNAs t... Read more »
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CUT&Tag

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