Tags | Diagenode

Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADPribosylation dependent manner to induce translational stalling.
Published: May, 2023

Abstract: In light of the numerous studies identifying post-transcriptional regulators on the surface of the endoplasmic reticulum (ER), we asked whether there are factors that regulate compartment specific mRNA translation in human cells. Using a proteomic...
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miR-210 expression is strongly hypoxia-induced in anaplastic thyroidcancer cell lines and is associated with extracellular vesicles \&Argonaute-2
Published: December, 2022

Abstract: Hypoxia, or low oxygen tension, is frequently found in highly proliferative solid tumors such as anaplastic thyroid carcinoma (ATC) and is believed to promote resistance to chemotherapy and radiation. Identifying hypoxic cells for targeted therapy...
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A Chromosomal Duplication Encompassing Interleukin-33 Causes aNovel Hyper IgE Phenotype Characterized by EosinophilicEsophagitis and Generalized Autoimmunity.
Published: April, 2022

Abstract: Interleukin (IL)-33 is a member of the IL-1 cytokine family and is secreted by fibroblasts, endothelial cells, and epithelial cells in tissues (lung, skin, and gastrointestinal) that are exposed to the environment. 1 IL-33 is stored in the nucleus...
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Light affects behavioral despair involving the clock gene Period 1.
Published: July, 2021

Abstract: Light at night has strong effects on physiology and behavior of mammals. It affects mood in humans, which is exploited as light therapy, and has been shown to reset the circadian clock in the suprachiasmatic nuclei (SCN). This resetting is paramou...
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Vesicle-bound regulatory RNAs are associated with tissue aging
Published: May, 2021

Abstract: Previous work on murine models and human demonstrated global as well as tissue-specific molecular aging trajectories in solid tissues and body fluids1–8. Extracellular vesicles like exosomes play a crucial role in communication and informati...
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miRMaster 2.0: multi-species non-coding RNA sequencing analyses at scale
Published: April, 2021

Abstract: Analyzing all features of small non-coding RNA sequencing data can be demanding and challenging. To facilitate this process, we developed miRMaster. After the analysis of over 125 000 human samples and 1.5 trillion human small RNA reads over 4 yea...
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Small-Medium Extracellular Vesicles and Their miRNA Cargo inRetinal Health and Degeneration: Mediators of Homeostasis, andVehicles for Targeted Gene Therapy.
Published: January, 2020

Abstract: Photoreceptor cell death and inflammation are known to occur progressively in retinal degenerative diseases such as age-related macular degeneration (AMD). However, the molecular mechanisms underlying these biological processes are largely unknown...
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The ribosomal protein S1-dependent standby site in mRNA consists ofa single-stranded region and a 5' structure element.
Published: August, 2019

Abstract: In bacteria, stable RNA structures that sequester ribosome-binding sites (RBS) impair translation initiation, and thus protein output. In some cases, ribosome standby can overcome inhibition by structure: 30S subunits bind sequence-nonspecifically...
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Web-based NGS data analysis using miRMaster: a large-scale meta-analysis of human miRNAs
Published: July, 2017

Abstract: The analysis of small RNA NGS data together with the discovery of new small RNAs is among the foremost challenges in life science. For the analysis of raw high-throughput sequencing data we implemented the fast, accurate and comprehensive web-base...
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mir-21 is associated with inactive low molecular weight Argonautecomplexes in thyroid cancer cell lines

Abstract: Thyroid cancer is the most prevalent endocrine malignancy. We and others have shown that several microRNAs, which are post-transcriptional gene regulators, are aberrantly expressed in anaplastic thyroid cancer (ATC) and papillary thyroid cancer (P...
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D-Plex RNA-seq kit

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