Two-factor authentication underpins the precision of the piRNA pathway Published: September, 2024 Abstract:
The PIWI-interacting RNA (piRNA) pathway guides the DNA methylation of young, active transposons during germline development in male mice. piRNAs tether the PIWI protein MIWI2 (PIWIL4) to the nascent transposon transcript, resulting in DNA methyla... Read more »
Spatial epigenome-transcriptome co-profiling of mammalian tissues. Published: April, 2023 Abstract:
Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics, are becoming powerful tools for profiling of cellular states in the tissue context. However, current methods capture only one layer of omics information at a... Read more »
Retrospective analysis of enhancer activity and transcriptome history. Published: February, 2023 Abstract:
Cell state changes in development and disease are controlled by gene regulatory networks, the dynamics of which are difficult to track in real time. In this study, we used an inducible DCM-RNA polymerase subunit b fusion protein which labels activ... Read more »
Spatially resolved epigenomic profiling of single cells in complex tissues Published: February, 2022 Abstract:
The recent development of spatial omics methods enables single-cell profiling of the transcriptome and the 3D genome organization in a spatially resolved manner. Expanding the repertoire of spatial omics tools, a spatial epigenomics method will ac... Read more »
ATRX regulates glial identity and the tumor microenvironment inIDH-mutant glioma Published: November, 2021 Abstract:
Background Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic... Read more »
Autocrine Vitamin D-signaling switches off pro-inflammatory programsof Th1 cells Published: October, 2021 Abstract:
The molecular mechanisms governing orderly shutdown and retraction of CD4+ T helper (Th)1 responses remain poorly understood. Here, we show that complement triggers contraction of Th1 responses by inducing intrinsic expression of the vitamin D (Vi... Read more »
