Tags | Diagenode

Genome-wide DNA methylation analysis in an antimigraine-treatedpreclinical model of cortical spreading depolarization.
Published: February, 2023

Abstract: BACKGROUND: Cortical spreading depolarization, the cause of migraine aura, is a short-lasting depolarization wave that moves across the brain cortex, transiently suppressing neuronal activity. Prophylactic treatments for migraine, such as topirama...
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Extra-hematopoietic immunomodulatory role of the guanine-exchange factorDOCK2.
Published: November, 2022

Abstract: Stromal cells interact with immune cells during initiation and resolution of immune responses, though the precise underlying mechanisms remain to be resolved. Lessons learned from stromal cell-based therapies indicate that environmental signals in...
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Cancer Detection and Classification by CpG Island Hypermethylation Signatures in Plasma Cell-Free DNA
Published: November, 2021

Abstract: Cell-free DNA (cfDNA) methylation has emerged as a promising biomarker for early cancer detection, tumor type classification, and treatment response monitoring. Enrichment-based cfDNA methylation profiling methods such as cfMeDIP-seq have shown hi...
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Transcriptome and Methylome Analysis Reveal ComplexCross-Talks between Thyroid Hormone and GlucocorticoidSignaling at Xenopus Metamorphosis.
Published: September, 2021

Abstract: BACKGROUND: Most work in endocrinology focus on the action of a single hormone, and very little on the cross-talks between two hormones. Here we characterize the nature of interactions between thyroid hormone and glucocorticoid signaling during me...
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Cell-free DNA methylome profiling by MBD-seq with ultra-low input
Published: March, 2021

Abstract: Methylation signatures in cell-free DNA (cfDNA) have shown great sensitivity and specificity in the characterization of tumour status and classification of tumour types, as well as the response to therapy and recurrence. Currently, most cfDNA meth...
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Genome-wide DNA methylation and RNA-seq analyses identify genes andpathways associated with doxorubicin resistance in a canine diffuse largeB-cell lymphoma cell line.
Published: January, 2021

Abstract: Doxorubicin resistance is a major challenge in the successful treatment of canine diffuse large B-cell lymphoma (cDLBCL). In the present study, MethylCap-seq and RNA-seq were performed to characterize the genome-wide DNA methylation and differenti...
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