Tags | Diagenode

Transcription of CLDND1 in human brain endothelial cells is regulated bythe myeloid zinc finger 1.
Published: October, 2020

Abstract: Increased permeability of endothelial cells lining the blood vessels in the brain leads to vascular oedema and, potentially, to stroke. The tight junctions (TJs), primarily responsible for the regulation of vascular permeability, are multi-protein...
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Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis.
Published: July, 2019

Abstract: Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis b...
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Resveratrol up-regulates ATP2A3 gene expression in breast cancer cell lines through epigenetic mechanisms.
Published: June, 2019

Abstract: Resveratrol (RSV) is a phytoestrogen which has been related to chemoprevention of several types of cancer. In this work, we show up to a 6-fold increased expression of ATP2A3 gene induced by RSV that triggers apoptosis and changes of intracellular...
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High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis.
Published: August, 2018

Abstract: While suppression of specific genes through aberrant promoter methylation contributes to different diseases including organ fibrosis, gene-specific reactivation technology is not yet available for therapy. TET enzymes catalyze hydroxymethylation o...
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Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β.
Published: August, 2018

Abstract: Human papillomavirus type 16 (HPV16) and other oncoviruses have been shown to block innate immune responses and to persist in the host. However, to avoid viral persistence, the immune response attempts to clear the infection. IL-1β is a power...
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Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β.
Published: August, 2018

Abstract: Human papillomavirus type 16 (HPV16) and other oncoviruses have been shown to block innate immune responses and to persist in the host. However, to avoid viral persistence, the immune response attempts to clear the infection. IL-1β is a power...
Read more »

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