Knockout of TRDMT1 methyltransferase affects DNA methylome inglioblastoma cells. Published: May, 2023 Abstract:
Purpose: We have previously shown that TRDMT1 methyltransferase is a regulator of chemotherapy-associated responses in glioblastoma cells. Despite the fact that glioblastoma, a common and malignant brain tumor, is widely characterized in term... Read more »
Epigenetic Suppression of the IL-7 Pathway in ProgressiveGlioblastoma. Published: September, 2022 Abstract:
BACKGROUND: Immune evasion in glioblastoma (GBM) shields cancer cells from cytotoxic immune response. METHODS: We investigated CpG methylation in promoters, genes, and pathways in 22 pairs of formalin-fixed paraffin-embedded sequential (FFPE) GBM ... Read more »
Muscle allele-specific expression QTLs may affect meat quality traitsin Bos indicus. Published: April, 2021 Abstract:
Single nucleotide polymorphisms (SNPs) located in transcript sequences showing allele-specific expression (ASE SNPs) were previously identified in the Longissimus thoracis muscle of a Nelore (Bos indicus) population consisting of 190 steers. Given... Read more »
DNA CpG methylation in sequential glioblastoma specimens. Published: August, 2020 Abstract:
PURPOSE: Glioblastoma is the most aggressive form of brain tumors. A better understanding of the molecular mechanisms leading to its evolution is essential for the development of treatments more effective than the available modalities. Here, we ai... Read more »
Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease Published: March, 2020 Abstract:
BACKGROUND: Cytosine methylation is an epigenetic mark that dictates cell fate and response to stimuli. The timing and establishment of methylation logic during kidney development remains unknown. DNA methyltransferase 3a and 3b are the enzymes ca... Read more »
DNA methylation and alcohol use disorders: Progress and challenges Published: October, 2016 Abstract:
Background and Objectives
Risk for alcohol use disorders (AUDs) is influenced by gene–environment interactions. Environmental factors can affect gene expression through epigenetic mechanisms such as DNA methylation. This review outlines t... Read more »
