FXR inhibition may protect from SARS-CoV-2 infection by reducingACE2. Published: December, 2022 Abstract:
Prevention of SARS-CoV-2 infection through the modulation of viral host receptors, such as ACE2, could represent a new chemoprophylactic approach for COVID-19 complementing vaccination. However, the mechanisms controlling ACE2 expression remain el... Read more »
Epigenetic Mechanisms Mediating Cell State Transitions in Chondrocytes Published: May, 2022 Abstract:
Epigenetic modifications play critical roles in regulating cell lineage differentiation, but the epigenetic mechanisms guiding specific differentiation steps within a cell lineage have rarely been investigated. To decipher such mechanisms, we used... Read more »
Autocrine Vitamin D-signaling switches off pro-inflammatory programsof Th1 cells Published: October, 2021 Abstract:
The molecular mechanisms governing orderly shutdown and retraction of CD4+ T helper (Th)1 responses remain poorly understood. Here, we show that complement triggers contraction of Th1 responses by inducing intrinsic expression of the vitamin D (Vi... Read more »
Altered Chromatin States Drive Cryptic Transcription in AgingMammalian Stem Cells. Published: August, 2021 Abstract:
A repressive chromatin state featuring trimethylated lysine 36 on histone H3 (H3K36me3) and DNA methylation suppresses cryptic transcription in embryonic stem cells. Cryptic transcription is elevated with age in yeast and nematodes, and reducing i... Read more »
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. Published: December, 2020 Abstract:
Linker histone H1 proteins bind to nucleosomes and facilitate chromatin compaction, although their biological functions are poorly understood. Mutations in the genes that encode H1 isoforms B-E (H1B, H1C, H1D and H1E; also known as H1-5, H1-2, H1-... Read more »
Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells. Published: August, 2019 Abstract:
Sox2 is a master transcriptional regulator of embryonic development. In this study, we determined the protein interactome of Sox2 in the chromatin and nucleoplasm of mouse embryonic stem (mES) cells. Apart from canonical interactions with pluripot... Read more »
Development and epigenetic plasticity of murine Müller glia. Published: July, 2019 Abstract:
The ability to regenerate the entire retina and restore lost sight after injury is found in some species and relies mostly on the epigenetic plasticity of Müller glia. To understand the role of mammalian Müller glia as a source of progen... Read more »
Whsc1 links pluripotency exit with mesendoderm specification. Published: July, 2019 Abstract:
How pluripotent stem cells differentiate into the main germ layers is a key question of developmental biology. Here, we show that the chromatin-related factor Whsc1 (also known as Nsd2 and MMSET) has a dual role in pluripotency exit and germ layer... Read more »
Spatial confinement downsizes the inflammatory response of macrophages. Published: December, 2018 Abstract:
Macrophages respond to chemical/metabolic and physical stimuli, but their effects cannot be readily decoupled in vivo during pro-inflammatory activation. Here, we show that preventing macrophage spreading by spatial confinement, as imposed by micr... Read more »
Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation. Published: June, 2018 Abstract:
Histone post-translational modifications (PTMs) are associated with epigenetic states that form the basis for cell-type-specific gene expression. Once established, histone PTMs can be maintained by positive feedback involving enzymes that recogniz... Read more »
A new metabolic gene signature in prostate cancer regulated by JMJD3 and EZH2. Published: May, 2018 Abstract:
Histone methylation is essential for gene expression control. Trimethylated lysine 27 of histone 3 (H3K27me3) is controlled by the balance between the activities of JMJD3 demethylase and EZH2 methyltransferase. This epigenetic mark has been shown ... Read more »
Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression Published: April, 2017 Abstract:
BACKGROUND:
H3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, the deregulation of H3K27me3 marks might play a role in prostate tumor progression.
METHODS:
We investigated genome-wide H3K27me3 histone methy... Read more »
Rebalancing gene haploinsufficiency in vivo by targeting chromatin Published: June, 2016 Abstract:
Congenital heart disease (CHD) affects eight out of 1,000 live births and is a major social and health-care burden. A common genetic cause of CHD is the 22q11.2 deletion, which is the basis of the homonymous deletion syndrome (22q11.2DS), also kno... Read more »
Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain Published: May, 2016 Abstract:
Chronic pain is a common and devastating condition that induces well-characterized changes in neurons and microglia. One major unanswered question is why these changes should persist long after the precipitating injury has healed. Here, we suggest... Read more »
Analysis of EZH2: micro-RNA network in low and high grade astrocytic tumors Published: January, 2016 Abstract:
Enhancer of Zeste homologue2 (EZH2) is an epigenetic regulator that functions as oncogene in astrocytic tumors, however, EZH2 regulation remains little studied. In this study, we measured EZH2 levels in low (Gr-II,DA) and high grade (Gr-IV,GBM) as... Read more »
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes Published: December, 2015 Abstract:
Erasure and subsequent reinstatement of DNA methylation in the germline, especially at imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms underlying DNA methylation establishment remain poorly understood, but a nu... Read more »
