Tags | Diagenode

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation.
Published: September, 2019

Abstract: Epigenetic regulators play a critical role in normal and malignant hematopoiesis. Deregulation, including epigenetic deregulation, of the gene cluster drives transformation of about 50% of acute myeloid leukemia. We recently showed that the Histon...
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The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer.
Published: January, 2019

Abstract: We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre-induced Wnt/β-catenin gain-of-function and Bmpr1a loss-of-functio...
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Genome-wide measurement of local nucleosome array regularity and spacing by nanopore sequencing.
Published: September, 2018

Abstract: The nature of chromatin as regular succession of nucleosomes has gained iconic status. However, since most nucleosomes in metazoans are poorly positioned it is unknown to which extent bulk genomic nucleosome repeat length reflects the regularity a...
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MeDIP combined with in-solution targeted enrichment followed by NGS: Inter-individual methylation variability of fetal-specific biomarkers and their implementation in a proof of concept study for NIPT.
Published: June, 2018

Abstract: DNA methylation is the most characterized epigenetic process exhibiting stochastic variation across different tissues and individuals. In non-invasive prenatal testing (NIPT) fetal specific methylated regions can potentially be used as biomarkers ...
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