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Ski8 polyclonal antibody

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Catalog Number

Format

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C15410012
(pAb-012-150)

150 µg/60 µl

$380.00
Bulk order

Alternative names: WDR61, REC14

Polyclonal antibody raised in rabbit against human SKI8, using a recombinant protein.

Lot	001
Concentration	2.5 µg/µl
Species reactivity	Drosophila, human
Type	Polyclonal
Purity	Protein G purified
Host	Rabbit
Precautions	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Applications	Suggested dilution	References
Western Blotting	1:1,000	Fig 1, Ref 1
ChIP	1 - 5 μg/ChIP	Ref 1

Validation Data

Figure 1. Western blot analysis using the Diagenode antibody directed against SKI8
Western blot was performed on nuclear extract from HeLa cells (lane 1), Drosophila adult whole cell extracts (lane 2), and the purified human PAF complex (lane 3) (Figure 1A) or on nuclear extracts from HeLa cells (HeLa NE, 20 μg) (Figure 1B), using the Diagenode antibody against SKI8 (Cat. No. pAb-012-150) diluted 1:1,000. The location of the protein is indicated on the right, the marker (in kDa) is shown on the left.

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Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a
Strikoudis A. et al.
Pluripotent embryonic stem cells (ESCs) self-renew or differentiate into all tissues of the developing embryo and cell-specification factors are necessary to balance gene expression. Here we delineate the function of the PHD-finger protein 5a (Phf5a) in ESC self-renewal and ascribe its role in regulating pluripotenc...

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<p><strong>ChIP results</strong> obtained with the antibody directed against H3K4me3 (Cat. No. <a href="../p/h3k4me3-polyclonal-antibody-premium-50-ug-50-ul">C15410003</a>).&nbsp;</p>
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<p><small><strong> Figure 1. Western blot analysis using the Diagenode antibody directed against SKI8 </strong><br />Western blot was performed on nuclear extract from HeLa cells (lane 1), Drosophila adult whole cell extracts (lane 2), and the purified human PAF complex (lane 3) (Figure 1A) or on nuclear extracts from HeLa cells (HeLa NE, 20 &mu;g) (Figure 1B), using the Diagenode antibody against SKI8 (Cat. No. pAb-012-150) diluted 1:1,000. The location of the protein is indicated on the right, the marker (in kDa) is shown on the left. </small></p>
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<p><small><strong> Figure 1. Western blot analysis using the Diagenode antibody directed against SKI8 </strong><br />Western blot was performed on nuclear extract from HeLa cells (lane 1), Drosophila adult whole cell extracts (lane 2), and the purified human PAF complex (lane 3) (Figure 1A) or on nuclear extracts from HeLa cells (HeLa NE, 20 &mu;g) (Figure 1B), using the Diagenode antibody against SKI8 (Cat. No. pAb-012-150) diluted 1:1,000. The location of the protein is indicated on the right, the marker (in kDa) is shown on the left. </small></p>
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<td>Fig 1, Ref 1</td>
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<p>Learn more about: <a href="https://www.diagenode.com/applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
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<p><span style="font-weight: 400;">Diagenode&rsquo;s highly validated antibodies:</span></p>
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<li>Highly sensitive and specific</li>
<li>Cost-effective (requires less antibody per reaction)</li>
<li>Batch-specific data is available on the website</li>
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<p><br />Chromatin immunoprecipitation (<b>ChIP</b>) is a technique to study the associations of proteins with the specific genomic regions in intact cells. One of the most important steps of this protocol is the immunoprecipitation of targeted protein using the antibody specifically recognizing it. The quality of antibodies used in ChIP is essential for the success of the experiment. Diagenode offers extensively validated ChIP-grade antibodies, confirmed for their specificity, and high level of performance in ChIP. Each batch is validated, and batch-specific data are available on the website.</p>
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<p><strong>ChIP results</strong> obtained with the antibody directed against H3K4me3 (Cat. No. <a href="../p/h3k4me3-polyclonal-antibody-premium-50-ug-50-ul">C15410003</a>).&nbsp;</p>
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<div class="small-12 medium-6 large-6 columns"><img src="https://www.diagenode.com/img/product/antibodies/C15410003-fig1-ChIP.jpg" alt="" width="400" height="315" />&nbsp;</div>
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<p>Our aim at Diagenode is to offer the largest collection of highly specific <strong>ChIP-grade antibodies</strong>. We add new antibodies monthly. Find your ChIP-grade antibody in the list below and check more information about tested applications, extensive validation data, and product information.</p>',
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			'description' => '<p>Pluripotent embryonic stem cells (ESCs) self-renew or differentiate into all tissues of the developing embryo and cell-specification factors are necessary to balance gene expression. Here we delineate the function of the PHD-finger protein 5a (Phf5a) in ESC self-renewal and ascribe its role in regulating pluripotency, cellular reprogramming and myoblast specification. We demonstrate that Phf5a is essential for maintaining pluripotency, since depleted ESCs exhibit hallmarks of differentiation. Mechanistically, we attribute Phf5a function to the stabilization of the Paf1 transcriptional complex and control of RNA polymerase II elongation on pluripotency loci. Apart from an ESC-specific factor, we demonstrate that Phf5a controls differentiation of adult myoblasts. Our findings suggest a potent mode of regulation by Phf5a in stem cells, which directs their transcriptional programme, ultimately regulating maintenance of pluripotency and cellular reprogramming.</p>',
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include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
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<p><strong>ChIP results</strong> obtained with the antibody directed against H3K4me3 (Cat. No. <a href="../p/h3k4me3-polyclonal-antibody-premium-50-ug-50-ul">C15410003</a>).&nbsp;</p>
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<p>Our aim at Diagenode is to offer the largest collection of highly specific <strong>ChIP-grade antibodies</strong>. We add new antibodies monthly. Find your ChIP-grade antibody in the list below and check more information about tested applications, extensive validation data, and product information.</p>',
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Datasheet SKI8 pAb-012-150 DATASHEET Datasheet description	Download
Antibodies you can trust POSTER Epigenetic research tools have evolved over time from endpoint PCR to qPCR to the analyses of lar...	Download
Epigenetic Antibodies Brochure BROCHURE More than in any other immuoprecipitation assays, quality antibodies are critical tools in many e...	Download

Ski8 antibody SDS GB en	Download
Ski8 antibody SDS US en	Download
Ski8 antibody SDS DE de	Download
Ski8 antibody SDS JP ja	Download
Ski8 antibody SDS BE nl	Download
Ski8 antibody SDS BE fr	Download
Ski8 antibody SDS FR fr	Download
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