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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Epigenetic and transcriptional determinants of the human breast.
Published: February, 2015
Abstract: While significant effort has been dedicated to the characterization of epigenetic changes associated with prenatal differentiation, relatively litt... Read more »
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DNA shearing Bioruptor
Stabilization of nontoxic Aβ-oligomers: insights into the mechanism...
Published: February, 2015
Abstract: The extracellular accumulation of amyloid β (Aβ) peptides is characteristic of Alzheimer's disease (AD). However, formation of diffusible, oligomer... Read more »
Reprogramming of the ERRα and ERα target gene landscape triggers ta...
Published: February, 2015
Abstract: Endocrine treatment regimens for breast cancer that target the estrogen receptor-α (ERα) are effective, but acquired resistance remains a limiting ... Read more »
A pro-apoptotic function of iASPP by stabilizing p300 and CBP throu...
Published: February, 2015
Abstract: The p53 family and its cofactors are potent inducers of apoptosis and form a barrier to cancer. Here, we investigated the impact of the supposedly ... Read more »
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Antibody
MEK guards proteome stability and inhibits tumor-suppressive amyloi...
Published: February, 2015
Abstract: Signaling through RAS/MAP kinase pathway is central to biology. ERK has long been perceived as the only substrate for MEK. Here, we report that HSF... Read more »
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Bioruptor
p73 engages A2B receptor signalling to prime cancer cells to chemot...
Published: February, 2015
Abstract: Tumour cells often acquire the ability to escape cell death, a key event leading to the development of cancer. In almost half of all human cancers,... Read more »
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Bioruptor Chromatin Shearing
Phylogenomics of Phrynosomatid Lizards: Conflicting Signals from Se...
Published: February, 2015
Abstract: Sequence capture and restriction site associated DNA sequencing (RADseq) are popular methods for obtaining large numbers of loci for phylogenetic a... Read more »
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DNA shearing Bioruptor
The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Act...
Published: February, 2015
Abstract: The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate tran... Read more »
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Bioruptor Chromatin Shearing ChIP-seq Antibody H3K27ac (C15410174)
Circulating nucleic acids damage DNA of healthy cells by integratin...
Published: February, 2015
Abstract: Whether nucleic acids that circulate in blood have any patho-physiological functions in the host have not been explored.We report here that far fro... Read more »
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DNA shearing Bioruptor
Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine...
Published: February, 2015
Abstract: Ten eleven translocation (Tet) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcyt... Read more »
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DNA shearing Bioruptor Chromatin Shearing ChIP-seq Antibody
Genipin as a novel chemical activator of EBV lytic cycle.
Published: February, 2015
Abstract: Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that causes acute infection and establishes life-long latency. EBV causes several human c... Read more »
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Bioruptor Cell Lysis Western Blot
Genome-wide and single-cell analyses reveal a context dependent rel...
Published: February, 2015
Abstract: Genome-wide distribution of histone H3K18 and H3K27 acetyltransferases, CBP (CREBBP) and p300 (EP300), is used to map enhancers and promoters, but ... Read more »
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Antibody
Discovery of transcription factors and regulatory regions driving i...
Published: February, 2015
Abstract: Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound t... Read more »
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Bioruptor Chromatin Shearing ChIP-seq
Increased HDAC3 and decreased miRNA-130a expression in PBMCs throu...
Published: February, 2015
Abstract: The study was performed to investigate the molecular mechanism for SCI patients. The interaction between miRNA-130a and HDAC was demonstrated in PB... Read more »
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Bioruptor Chromatin Shearing
Direct entry by RNase E is a major pathway for the degradation and ...
Published: February, 2015
Abstract: Escherichia coli endoribonuclease E has a major influence on gene expression. It is essential for the maturation of ribosomal and transfer RNA as w... Read more »
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Bioruptor Bioruptor Plus RNA Shearing
Tat predominantly associates with host promoter elements in HIV-1-i...
Published: February, 2015
Abstract: UNLABELLED: HIV-1 Tat is a multifunctional regulatory protein that, in addition to its primary function of transactivating viral transcription, als... Read more »
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Bioruptor Chromatin Shearing
A transient wave of BMP signaling in the retina is necessary for Mü...
Published: February, 2015
Abstract: The primary glial cells in the retina, the Müller glia, differentiate from retinal progenitors in the first postnatal week. CNTF/LIF/STAT3 signalin... Read more »
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LowCell ChIP kit
Polycomb YY1 is a critical interface between epigenetic code and mi...
Published: January, 2015
Abstract: Yin Yang 1 (YY1) is a member of polycomb protein family involved in epigenetic modifications and transcriptional controls. We have shown that YY1 a... Read more »
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Bioruptor Chromatin Shearing
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modu...
Published: January, 2015
Abstract: Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whet... Read more »
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Bioruptor Tissue Homogenization
Curcumin inhibits anchorage-independent growth of HT29 human colon ...
Published: January, 2015
Abstract: Colorectal cancer remains the most prevalent malignancy in humans. The impact of epigenetic alterations on the development of this complex disease ... Read more »
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DNA shearing Bioruptor
Reduced Expression of MYC Increases Longevity and Enhances Healthspan.
Published: January, 2015
Abstract: MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In contrast, we find that Myc haploinsufficient (Myc(+/-)) mic... Read more »
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Bioruptor Chromatin Shearing
Ligand-dependent enhancer activation regulated by topoisomerase-I a...
Published: January, 2015
Abstract: The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. ... Read more »
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Bioruptor Chromatin Shearing
A small peptide derived from p53 linker region can resume the apopt...
Published: January, 2015
Abstract: One of the most important tumor suppression functions of p53 is its ability to induce apoptosis. iASPP is an inhibitory member of the ASPP protein ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Stable X Chromosome Reactivation in Female Human Induced Pluripoten...
Published: January, 2015
Abstract: In placental mammals, balanced expression of X-linked genes is accomplished by X chromosome inactivation (XCI) in female cells. In humans, random X... Read more »
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Antibody
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumor...
Published: January, 2015
Abstract: Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model o... Read more »
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Bioruptor Chromatin Shearing
Age dependent changes in the LPS induced transcriptome of bovine de...
Published: January, 2015
Abstract: BackgroundBy comparing fibroblasts collected from animals at 5-months or 16-months of age we have previously found that the cultures from older ani... Read more »
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DNA shearing Bioruptor Bioruptor Plus
Pharmacologically relevant doses of valproate upregulate CD20 expre...
Published: January, 2015
Abstract: Background Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have been proposed as potential new therapies for lymphoid mal... Read more »
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Bioruptor Cell Lysis Western Blot
Embryonic stem cell differentiation requires full length Chd1.
Published: January, 2015
Abstract: The modulation of chromatin dynamics by ATP-dependent chromatin remodeling factors has been recognized as an important mechanism to regulate the ba... Read more »
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Antibody H3K4me3 (C15410003)
Emergence of differentially regulated pathways associated with the ...
Published: January, 2015
Abstract: BackgroundRegional specificity allows different skin regions to exhibit different characteristics, enabling complementary functions to make effecti... Read more »
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LowCell ChIP kit
Dppa3 expression is critical for generation of fully reprogrammed i...
Published: January, 2015
Abstract: Reprogramming of mouse somatic cells into induced pluripotent stem cells (iPSCs) often generates partially reprogrammed iPSCs (pre-iPSCs), low-grad... Read more »
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Bioruptor Chromatin Shearing

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