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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

MARTRE family proteins negatively regulate CCR4-NOT activity to pro...
Published: January, 2025
Abstract: The mammalian early embryo development requires translation of maternal mRNA inherited from the oocyte. While poly(A) tail length influences mRNA t... Read more »
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D-Plex small RNA-seq
A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activatio...
Published: January, 2025
Abstract: A20, encoded by the TNFAIP3 gene, is a protein linked to Crohn's disease and celiac disease in humans. We now find that mice expressing p... Read more »
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Tagmentase
MECOM is a master repressor of myeloid differentiation through dose...
Published: January, 2025
Abstract: Enhancer translocations, due to 3q26 rearrangements, drive out-of-context MECOM expression in an aggressive subtype of acute myeloid leukemia (AML)... Read more »
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Antibody Microplex Library Preparation kit
Dysregulation of Myelination in Focal Cortical Dysplasia Type II of...
Published: December, 2024
Abstract: Focal cortical dysplasias (FCDs) are local malformations of the human neocortex and a leading cause of intractable epilepsy. FCDs are classified in... Read more »
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IPure kit iDeal ChIP-seq Kit for Transcription Factors
Mission SpaceX CRS-19 RRRM-1 space flight induced skin genomic plas...
Published: December, 2024
Abstract: Highlights Exposure to space environment causes genome-wide adaptive epigenetic changes Space-exposure adaptive genome-wide changes a... Read more »
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Premium RRBS Kit DNA Methylation Profiling (RRBS Service)
Histone variant H3.5 in testicular cell differentiation and its int...
Published: December, 2024
Abstract: Testicular cell differentiation is a highly regulated process, essential for male reproductive health. The histone variant H3.5 is apparently a cri... Read more »
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MagMeDIP kit
TurboCas: A method for locus-specific labeling of genomic regions a...
Published: December, 2024
Abstract: Regulation of gene expression during development and stress response requires the concerted action of transcription factors and chromatin-binding p... Read more »
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CRISPR
The oncogenic lncRNA MIR503HG suppresses cellular senescence counte...
Published: December, 2024
Abstract: Background The androgen receptor (AR), a ligand-dependent transcription factor, plays a key role in regulating prostate cancer (PCa) growth. The n... Read more »
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iDeal ChIP-seq Kit for Transcription Factors
Independent evaluation of an 11-CpG panel for age estimation in blood
Published: December, 2024
Abstract: Highlights A set of 11 CpGs for age prediction was investigated in 148 Danish blood samples. Assay optimization improved covera... Read more »
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Premium Bisulfite Kit
Exploring the Epigenetic Landscape of Spermatozoa: Impact of Oxidat...
Published: December, 2024
Abstract: Reproductive success is dependent on gamete integrity, and oxidative stress alters male nuclei, meaning that no DNA repair is possible due to chrom... Read more »
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Antibody
PDGFRA is a conserved HAND2 effector during early cardiac development
Published: December, 2024
Abstract: The basic helix–loop–helix transcription factor HAND2 has multiple roles during vertebrate organogenesis, including cardiogenesis. Howe... Read more »
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True MicroChIP kit
EOMES establishes mesoderm and endoderm differentiation potential t...
Published: December, 2024
Abstract: Highlights Enhancer chromatin is dynamically remodeled during mesoderm/endoderm (ME) differentiation Global ME enhancer accessi... Read more »
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Antibody iDeal ChIP-seq Kit for Transcription Factors
Plasma cell-free DNA chromatin immunoprecipitation profiling depict...
Published: December, 2024
Abstract: Cell phenotype underlies prostate cancer presentation and treatment resistance and can be regulated by epigenomic features. However, the osteotropi... Read more »
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Antibody
Spatial organizations of heterochromatin underpin nuclear structura...
Published: December, 2024
Abstract: Highlights Cardiomyocytes acquire characteristic spatial organizations of heterochromatin (SOH) High levels of H2B-mCherry disr... Read more »
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ATAC-seq
Interferon-gamma rescues FK506 dampened dendritic cell calcineurin-...
Published: December, 2024
Abstract: IScience Highlights Calcineurin inhibitors block DC maturation in response to A. fumigatus Lack of DC maturation impairs T... Read more »
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Antibody IPure kit Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones
ETV2/ER71 regulates hematovascular lineage generation and vasculari...
Published: December, 2024
Abstract: Highlights Interaction of ETV2 and KDM4A decreases H3K9 trimethylation on hematovascular genes. ETV2 and KDM4A cooperatively re... Read more »
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Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones Chromatin Profiling (ChIP-seq) Services
Epi-microRNA mediated metabolic reprogramming counteracts hypoxia t...
Published: December, 2024
Abstract: To increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centers (... Read more »
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Microplex Library Preparation kit
NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive ge...
Published: November, 2024
Abstract: Highlights Degradation of NUP98-fp halts nascent transcription of key oncogenes within 1 h NUP98-fp loss results in accumulat... Read more »
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Antibody
HIRA protects telomeres against R-loop-induced instability in ALT c...
Published: November, 2024
Abstract: Highlights HIRA establishes greater telomeric chromatin accessibility after ATRX-DAXX loss Deposition of new H3.3 by HIRA-UBN r... Read more »
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Tagmentase
Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor act...
Published: November, 2024
Abstract: Peroxiredoxin 1 (PRDX1), an intracellular antioxidant enzyme, has emerged as a regulator of inflammatory responses via Toll-like receptor 4 (TLR4) ... Read more »
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Antibody
The Novel Direct AR Target Gene Annexin A2 Mediates Androgen-Induce...
Published: November, 2024
Abstract: Clinical trials for prostate cancer (PCa) patients have implemented the bipolar androgen therapy (BAT) that includes the treatment with supraphysio... Read more »
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iDeal ChIP-seq Kit for Transcription Factors
TEAD-targeting small molecules induce a cofactor switch to regulate...
Published: November, 2024
Abstract: TEAD proteins are the main transcriptional effectors of the Hippo signaling pathway and a pharmacological target in oncology. Most TEAD-targeting s... Read more »
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Microplex Library Preparation kit iDeal ChIP-seq Kit for Transcription Factors Chromatin Profiling (ChIP-seq) Services
Nuclear localization of MTHFD2 is required for correct mitosis prog...
Published: November, 2024
Abstract: Subcellular compartmentalization of metabolic enzymes establishes a unique metabolic environment that elicits specific cellular functions. Indeed, ... Read more »
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Antibody
Claudin-1 as a potential marker of stress-induced premature senesce...
Published: November, 2024
Abstract: Cellular senescence, a permanent state of cell cycle arrest, can result either from external stress and is then called stress-induced premature sen... Read more »
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Antibody iDeal ChIP-seq Kit for Histones
Engineered PsCas9 enables therapeutic genome editing in mouse liver...
Published: November, 2024
Abstract: Clinical implementation of therapeutic genome editing relies on efficient in vivo delivery and the safety of CRISPR-Cas tools. Previously, we ident... Read more »
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Tagmentase
ACE2 Enhances Sensitivity to PD-L1 Blockade by Inhibiting Macrophag...
Published: November, 2024
Abstract: Anti-PD-L1-based combination immunotherapy has become the first-line treatment for unresectable hepatocellular carcinoma (HCC). However, the object... Read more »
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Microplex Library Preparation kit
The molecular consequences of FOXF1 missense mutations associated w...
Published: November, 2024
Abstract: Background Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a fatal congenital lung disorder strongly associated wit... Read more »
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CUT&Tag
Atypical chemokine receptor 2 expression is directly regulated by h...
Published: November, 2024
Abstract: Lack of significant and durable clinical benefit from anti-cancer immunotherapies is partly due to the failure of cytotoxic immune cells to infiltr... Read more »
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iDeal ChIP-qPCR
ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fa...
Published: November, 2024
Abstract: SREBF1 plays the central role in lipid metabolism. It has been known that full-length SREBF1 that did not associate with SCAP (SCAP-free SREBF1) is... Read more »
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Tagmentase
Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticit...
Published: October, 2024
Abstract: Cancer cell plasticity contributes significantly to the failure of chemo- and targeted therapies in triple-negative breast cancer (TNBC). Molecular... Read more »
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iDeal ChIP-seq Kit for Transcription Factors

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