Pervasive translation of Xrn1-sensitive unstable long non-coding RNAs in yeast Published: March, 2024 Abstract:
Despite being predicted to lack coding potential, cytoplasmic long non-coding (lnc)RNAs can associate with ribosomes. However, the landscape and biological relevance of lncRNAs translation remains poorly studied. In yeast, cytoplasmic Xrn1-sensiti... Read more »
Single-cell quantification of ribosome occupancy in early mouse development Published: June, 2023 Abstract:
Translation regulation is critical for early mammalian embryonic development1. However, previous studies had been restricted to bulk measurements2, precluding precise determination of translation regulation including allele-specific analyses. Here... Read more »
Ageing-associated small RNA cargo of extracellular vesicles. Published: January, 2023 Abstract:
Previous work on murine models and humans demonstrated global as well as tissue-specific molecular ageing trajectories of RNAs. Extracellular vesicles (EVs) are membrane vesicles mediating the horizontal transfer of genetic information between dif... Read more »
Diverse Monogenic Subforms of Human Spermatogenic Failure Published: July, 2022 Abstract:
Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically incurable with current medicine. Due to the biological complexity of sperm production, defining the genetic basis of NOA has proven challenging, and to dat... Read more »
Single cell quantification of ribosome occupancy in early mouse development Published: December, 2021 Abstract:
Technological limitations precluded transcriptome-wide analyses of translation at single cell resolution. To solve this challenge, we developed a novel microfluidic isotachophoresis approach, named RIBOsome profiling via IsoTachoPhoresis (Ribo-ITP... Read more »
Functional microRNA targetome undergoes degeneration-induced shift inthe retina. Published: August, 2021 Abstract:
BACKGROUND: MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through their association with argonau... Read more »
Small RNAs in Seminal Plasma as Novel Biomarkers for Germ Cell Tumors Published: May, 2021 Abstract:
Circulating miRNAs secreted by testicular germ cell tumors (TGCT) show great potential as novel non-invasive biomarkers for diagnosis of TGCT. Seminal plasma (SP) represents a biofluid closer to the primary site. Here, we investigate whether small... Read more »
Small RNAs in Seminal Plasma as Novel Biomarkers for GermCell Tumors. Published: May, 2021 Abstract:
Circulating miRNAs secreted by testicular germ cell tumors (TGCT) show great potential as novel non-invasive biomarkers for diagnosis of TGCT. Seminal plasma (SP) represents a biofluid closer to the primary site. Here, we investigate whether small... Read more »
Interspecies RNA Interactome of Pathogen and Host in a Heritable Defensive Strategy. Published: January, 2021 Abstract:
Communication with bacteria deeply impacts the life history traits of their hosts. Through specific molecules and metabolites, bacteria can promote short- and long-term phenotypic and behavioral changes in the nematode . The chronic exposure of to... Read more »
Distinct Extracellular RNA Profiles in Different PlasmaComponents. Published: January, 2021 Abstract:
Circulating extracellular RNAs (exRNAs) have great potential to serve as biomarkers for a wide range of diagnostic, therapeutic, and prognostic applications. So far, knowledge of the difference among different sources of exRNAs is limited. To addr... Read more »
