Immune disease variants modulate gene expression in regulatory CD4T cells. Published: April, 2022 Abstract:
Identifying cellular functions dysregulated by disease-associated variants could implicate novel pathways for drug targeting or modulation in cell therapies. However, follow-up studies can be challenging if disease-relevant cell types are difficul... Read more »
Broad domains of histone marks in the highly compact macronucleargenome. Published: April, 2022 Abstract:
The unicellular ciliate contains a large vegetative macronucleus with several unusual characteristics, including an extremely high coding density and high polyploidy. As macronculear chromatin is devoid of heterochromatin, our study characterizes ... Read more »
Effects of GSK-J4 on JMJD3 Histone Demethylase in MouseProstate Cancer Xenografts. Published: January, 2022 Abstract:
BACKGROUND/AIM: Histone methylation status is required to control gene expression. H3K27me3 is an epigenetic tri-methylation modification to histone H3 controlled by the demethylase JMJD3. JMJD3 is dysregulated in a wide range of cancers and has b... Read more »
Comprehensive characterization of the epigenetic landscape in Multiple
Myeloma Published: January, 2022 Abstract:
Background: Human multiple myeloma (MM) cell lines (HMCLs) have
been widely used to understand the molecular processes that drive MM
biology. Epigenetic modifications are involved in MM development,
progression, and drug resistance. A comprehensiv... Read more »
Epigenetic Drifts during Long-Term Intestinal OrganoidCulture Published: July, 2021 Abstract:
Organoids retain the morphological and molecular patterns of their tissue of origin, are self-organizing, relatively simple to handle and accessible to genetic engineering. Thus, they represent an optimal tool for studying the mechanisms of tissue... Read more »
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Published: December, 2020 Abstract:
Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here we show that 50\% of G34R/V tumors (n&nbs... Read more »
Macrophage Immune Memory Controls Endometriosis in Mice and Humans. Published: November, 2020 Abstract:
Endometriosis is a frequent, chronic, inflammatory gynecological disease characterized by the presence of ectopic endometrial tissue causing pain and infertility. Macrophages have a central role in lesion establishment and maintenance by driving c... Read more »
N-Methyladenosine co-transcriptionally directs the demethylation of histoneH3K9me2. Published: August, 2020 Abstract:
A dynamic epigenome is critical for appropriate gene expression in development and health. Central to this is the intricate process of transcription, which integrates cellular signaling with chromatin changes, transcriptional machinery and modific... Read more »
MYCN amplification and ATRX mutations are incompatible in neuroblastoma. Published: February, 2020 Abstract:
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correl... Read more »
Trained immunity modulates inflammation-induced fibrosis. Published: December, 2019 Abstract:
Chronic inflammation and fibrosis can result from inappropriately activated immune responses that are mediated by macrophages. Macrophages can acquire memory-like characteristics in response to antigen exposure. Here, we show the effect of BCG or ... Read more »
Nucleome Dynamics during Retinal Development. Published: August, 2019 Abstract:
More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhancers are also active in the developing retinae, many having features of cell- and developmental stage-... Read more »
The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Published: January, 2019 Abstract:
We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre-induced Wnt/β-catenin gain-of-function and Bmpr1a loss-of-functio... Read more »
