Human ChIP-seq grade H19 imprinting control region primer pair

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<p><abstracttext label="OBJECTIVES" nlmcategory="OBJECTIVE">To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region.</abstracttext></p>
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<p><abstracttext label="RESULTS" nlmcategory="RESULTS">Conditional analysis identified rs11209032 as the probable causal SNP within a 1.14 kb putative enhancer between IL23R and IL12RB2. Reduced luciferase activity was seen for the risk allele (p&lt;0.001) and reduced H3K4me1 methylation observed in CD4+ T-cells from 'A/A' homozygotes (p=0.02). The binding of nuclear extract to the risk allele was decreased &sim;3.5-fold compared with the protective allele (p&lt;0.001). The proportion of IFN-&gamma;+ CD4+ T-cells was increased in 'A/A' homozygotes (p=0.004), but neither IL23R nor IL12RB2 mRNA was affected.</abstracttext></p>
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View::_evaluate() - CORE/Cake/View/View.php, line 971
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Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
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Notice (8): Undefined variable: header [APP/View/Products/view.ctp, line 755]
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include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

Notice (8): Undefined variable: campaign_id [APP/View/Products/view.ctp, line 755]
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			'description' => '<h4>OBJECTIVES:</h4>
<p><abstracttext label="OBJECTIVES" nlmcategory="OBJECTIVE">To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region.</abstracttext></p>
<h4>METHODS:</h4>
<p><abstracttext label="METHODS" nlmcategory="METHODS">We performed conditional analysis on genetic association data and used epigenetic data on chromatin remodelling and transcription factor (TF) binding to identify the primary AS-associated IL23R-IL12RB2 intergenic SNP. Functional effects were tested in luciferase reporter assays in HEK293T cells and allele-specific TF binding was investigated by electrophoretic mobility gel shift assays. IL23R and IL12RB2 mRNA levels in CD4+ T cells were compared between cases homozygous for the AS-risk 'A' allele and the protective 'G' allele. The proportions of interleukin (IL)-17A+ and interferon (IFN)-&gamma;+ CD4+ T-cells were measured by fluorescence-activated cell sorting and compared between these AS-risk and protective genotypes.</abstracttext></p>
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<p><abstracttext label="RESULTS" nlmcategory="RESULTS">Conditional analysis identified rs11209032 as the probable causal SNP within a 1.14 kb putative enhancer between IL23R and IL12RB2. Reduced luciferase activity was seen for the risk allele (p&lt;0.001) and reduced H3K4me1 methylation observed in CD4+ T-cells from 'A/A' homozygotes (p=0.02). The binding of nuclear extract to the risk allele was decreased &sim;3.5-fold compared with the protective allele (p&lt;0.001). The proportion of IFN-&gamma;+ CD4+ T-cells was increased in 'A/A' homozygotes (p=0.004), but neither IL23R nor IL12RB2 mRNA was affected.</abstracttext></p>
<h4>CONCLUSIONS:</h4>
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	'antibody_id' => null,
	'name' => 'Human ChIP-seq grade H19 imprinting control region primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region from the H19 imprinting control region. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
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	'id' => '2550',
	'antibody_id' => null,
	'name' => 'Human ChIP-seq grade H19 imprinting control region primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region from the H19 imprinting control region. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
	'label1' => '',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '500 µl',
	'catalog_number' => 'C17011049-500',
	'old_catalog_number' => '',
	'sf_code' => 'C17011049-D001-000015',
	'type' => 'FRE',
	'search_order' => '04-undefined',
	'price_EUR' => '115',
	'price_USD' => '100',
	'price_GBP' => '105',
	'price_JPY' => '18015',
	'price_CNY' => '',
	'price_AUD' => '250',
	'country' => 'ALL',
	'except_countries' => 'None',
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	'in_stock' => false,
	'featured' => true,
	'no_promo' => false,
	'online' => true,
	'master' => false,
	'last_datasheet_update' => '0000-00-00',
	'slug' => 'human-chip-seq-grade-h19-imprinting-control-region-primer-pair-500-ul',
	'meta_title' => 'Human ChIP-seq grade H19 imprinting control region primer pair',
	'meta_keywords' => '',
	'meta_description' => 'Human ChIP-seq grade H19 imprinting control region primer pair',
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	'url' => 'files/products/reagents/primer_pairs/TDS-C17011049-H19-pp.pdf',
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	'name' => 'ChIP-seq grade H19 imprinting control region primer pair SDS JP ja',
	'language' => 'ja',
	'url' => 'files/SDS/ChIP-seq_grade_H19/SDS-C17011049-ChIP-seq_grade_H19_imprinting_control_region_primer_pair-JP-ja-GHS_2_0.pdf',
	'countries' => 'JP',
	'modified' => '2023-01-16 11:10:01',
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	'name' => 'An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.',
	'authors' => 'Roberts AR et al.',
	'description' => '<h4>OBJECTIVES:</h4>
<p><abstracttext label="OBJECTIVES" nlmcategory="OBJECTIVE">To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region.</abstracttext></p>
<h4>METHODS:</h4>
<p><abstracttext label="METHODS" nlmcategory="METHODS">We performed conditional analysis on genetic association data and used epigenetic data on chromatin remodelling and transcription factor (TF) binding to identify the primary AS-associated IL23R-IL12RB2 intergenic SNP. Functional effects were tested in luciferase reporter assays in HEK293T cells and allele-specific TF binding was investigated by electrophoretic mobility gel shift assays. IL23R and IL12RB2 mRNA levels in CD4+ T cells were compared between cases homozygous for the AS-risk 'A' allele and the protective 'G' allele. The proportions of interleukin (IL)-17A+ and interferon (IFN)-&gamma;+ CD4+ T-cells were measured by fluorescence-activated cell sorting and compared between these AS-risk and protective genotypes.</abstracttext></p>
<h4>RESULTS:</h4>
<p><abstracttext label="RESULTS" nlmcategory="RESULTS">Conditional analysis identified rs11209032 as the probable causal SNP within a 1.14 kb putative enhancer between IL23R and IL12RB2. Reduced luciferase activity was seen for the risk allele (p&lt;0.001) and reduced H3K4me1 methylation observed in CD4+ T-cells from 'A/A' homozygotes (p=0.02). The binding of nuclear extract to the risk allele was decreased &sim;3.5-fold compared with the protective allele (p&lt;0.001). The proportion of IFN-&gamma;+ CD4+ T-cells was increased in 'A/A' homozygotes (p=0.004), but neither IL23R nor IL12RB2 mRNA was affected.</abstracttext></p>
<h4>CONCLUSIONS:</h4>
<p><abstracttext label="CONCLUSIONS" nlmcategory="CONCLUSIONS">The rs11209032 SNP downstream of IL23R forms part of an enhancer, allelic variation of which may influence Th1-cell numbers. Homozygosity for the risk 'A' allele is associated with more IFN-&gamma;-secreting (Th1) cells. Further work is necessary to explain the mechanisms for these important observations.</abstracttext></p>',
	'date' => '2016-02-25',
	'pmid' => 'https://www.ncbi.nlm.nih.gov/pubmed/26916345',
	'doi' => '',
	'modified' => '2016-09-27 23:14:18',
	'created' => '2016-09-27 23:14:18',
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		'publication_id' => '3037'
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$externalLink = ' <a href="https://www.ncbi.nlm.nih.gov/pubmed/26916345" target="_blank"><i class="fa fa-external-link"></i></a>'
include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118