MeCP2 peptide

Catalog Number

Format

Price

C16000052
(sp-052-050)

50 µg/50 µl

$115.00

Synthetic peptide derived from the C-terminus of the mouse MeCP2 protein.
This peptide was used as immunogen to raise the Diagenode ChIP-grade antibody directed against MeCP2 (Cat. No. pAb-052-050). The same peptide can be used to block this antibody in negative control experiments.

For more information about MeCP2: see overview in the Technical Data Sheet of our ChIP-grade antibody directed against MeCP2 (Cat. No. pAb-052-050).

Documents
Datasheet MeCP2 sp052 DATASHEET
Datasheet description Download
Datasheet MeCP2 pAb-052-050 DATASHEET
Datasheet description Download

Publications

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Epigenetic Silencing of OR and TAS2R Genes Expression inHuman Orbitofrontal Cortex At Early Stages of SporadicAlzheimer’s Disease
Alves Victoria Cunha et al.
Modulation of brain olfactory (OR) and taste receptors (TASR) expression was recently reported in neurological diseases. We explored the possible expression and regulation of selected OR and TASR genes in human orbitofrontal cortex of sporadic Alzheimer’s disease (AD) and found that these are expressed and mar...

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include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

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include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

Notice (8): Undefined variable: campaign_id [APP/View/Products/view.ctp, line 755]Code Context<!-- BEGIN: REQUEST_FORM MODAL -->
<div id="request_formModal" class="reveal-modal medium" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog">
    <?= $this->element('Forms/simple_form', array('solution_of_interest' => $solution_of_interest, 'header' => $header, 'message' => $message, 'campaign_id' => $campaign_id)) ?>
$viewFile = '/home/website-server/www/app/View/Products/view.ctp'
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	'meta_keywords' => '',
	'meta_description' => 'MeCP2 peptide',
	'meta_title' => 'MeCP2 peptide',
	'product' => array(
		'Product' => array(
			'id' => '2445',
			'antibody_id' => null,
			'name' => 'MeCP2 peptide',
			'description' => '<p><span>Synthetic peptide derived from the C-terminus of the mouse MeCP2 protein.&nbsp;</span><br /><span>This peptide was used as immunogen to raise the Diagenode ChIP-grade antibody directed against MeCP2 (Cat. No. pAb-052-050). The same peptide can be used to block this antibody in negative control experiments.&nbsp;</span><br /><br /><span>For more information about MeCP2: see overview in the Technical Data Sheet of our ChIP-grade antibody directed against MeCP2 (Cat. No. pAb-052-050).</span></p>',
			'label1' => '',
			'info1' => '',
			'label2' => '',
			'info2' => '',
			'label3' => '',
			'info3' => '',
			'format' => '50 µg/50 µl',
			'catalog_number' => 'C16000052',
			'old_catalog_number' => 'sp-052-050',
			'sf_code' => 'C16000052-D001-000581',
			'type' => 'FRE',
			'search_order' => '04-undefined',
			'price_EUR' => '90',
			'price_USD' => '115',
			'price_GBP' => '80',
			'price_JPY' => '14100',
			'price_CNY' => '',
			'price_AUD' => '288',
			'country' => 'ALL',
			'except_countries' => 'None',
			'quote' => false,
			'in_stock' => false,
			'featured' => false,
			'no_promo' => false,
			'online' => true,
			'master' => true,
			'last_datasheet_update' => '0000-00-00',
			'slug' => 'mecp2-peptide-50-ug-50-ul',
			'meta_title' => 'MeCP2 peptide',
			'meta_keywords' => '',
			'meta_description' => 'MeCP2 peptide',
			'modified' => '2015-07-24 10:42:53',
			'created' => '2015-06-29 14:08:20',
			'locale' => 'eng'
		),
		'Antibody' => array(
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			'application_table' => null,
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			'storage_buffer' => null,
			'precautions' => null,
			'uniprot_acc' => null,
			'slug' => null,
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => null,
			'created' => null,
			'select_label' => null
		),
		'Slave' => array(),
		'Group' => array(),
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		'Testimonial' => array(),
		'Area' => array(),
		'SafetySheet' => array()
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)
$language = 'en'
$meta_keywords = ''
$meta_description = 'MeCP2 peptide'
$meta_title = 'MeCP2 peptide'
$product = array(
	'Product' => array(
		'id' => '2445',
		'antibody_id' => null,
		'name' => 'MeCP2 peptide',
		'description' => '<p><span>Synthetic peptide derived from the C-terminus of the mouse MeCP2 protein.&nbsp;</span><br /><span>This peptide was used as immunogen to raise the Diagenode ChIP-grade antibody directed against MeCP2 (Cat. No. pAb-052-050). The same peptide can be used to block this antibody in negative control experiments.&nbsp;</span><br /><br /><span>For more information about MeCP2: see overview in the Technical Data Sheet of our ChIP-grade antibody directed against MeCP2 (Cat. No. pAb-052-050).</span></p>',
		'label1' => '',
		'info1' => '',
		'label2' => '',
		'info2' => '',
		'label3' => '',
		'info3' => '',
		'format' => '50 µg/50 µl',
		'catalog_number' => 'C16000052',
		'old_catalog_number' => 'sp-052-050',
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		'type' => 'FRE',
		'search_order' => '04-undefined',
		'price_EUR' => '90',
		'price_USD' => '115',
		'price_GBP' => '80',
		'price_JPY' => '14100',
		'price_CNY' => '',
		'price_AUD' => '288',
		'country' => 'ALL',
		'except_countries' => 'None',
		'quote' => false,
		'in_stock' => false,
		'featured' => false,
		'no_promo' => false,
		'online' => true,
		'master' => true,
		'last_datasheet_update' => '0000-00-00',
		'slug' => 'mecp2-peptide-50-ug-50-ul',
		'meta_title' => 'MeCP2 peptide',
		'meta_keywords' => '',
		'meta_description' => 'MeCP2 peptide',
		'modified' => '2015-07-24 10:42:53',
		'created' => '2015-06-29 14:08:20',
		'locale' => 'eng'
	),
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		'name' => null,
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	),
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	'Application' => array(),
	'Category' => array(
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			'id' => '93',
			'position' => '3',
			'parent_id' => '36',
			'name' => 'Peptides',
			'description' => '',
			'no_promo' => false,
			'in_menu' => true,
			'online' => true,
			'tabular' => true,
			'hide' => false,
			'all_format' => false,
			'is_antibody' => false,
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			'cookies_tag_id' => null,
			'meta_keywords' => 'Peptides ,Proteins ',
			'meta_description' => 'Diagenode offers wide range of Peptides ',
			'meta_title' => 'Peptides & Proteins | Diagenode',
			'modified' => '2016-01-21 15:58:23',
			'created' => '2015-09-21 14:44:25',
			'ProductsCategory' => array(
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			'CookiesTag' => array([maximum depth reached])
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			'image_id' => null,
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			'url' => 'files/products/reagents/peptides/Datasheet_MeCP2_sp052.pdf',
			'slug' => 'datasheet-mecp2-sp052',
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => '2015-07-07 11:47:43',
			'created' => '2015-07-07 11:47:43',
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		(int) 1 => array(
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			'description' => 'Datasheet description',
			'image_id' => null,
			'type' => 'Datasheet',
			'url' => 'files/products/antibodies/Datasheet_MeCP2_pAb-052-050.pdf',
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			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => '2015-07-07 11:47:44',
			'created' => '2015-07-07 11:47:44',
			'ProductsDocument' => array(
				[maximum depth reached]
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	'Image' => array(),
	'Promotion' => array(),
	'Protocol' => array(),
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			'name' => 'Epigenetic Silencing of OR and TAS2R Genes Expression inHuman Orbitofrontal Cortex At Early Stages of SporadicAlzheimer’s Disease',
			'authors' => 'Alves Victoria Cunha et al.',
			'description' => '<p>Modulation of brain olfactory (OR) and taste receptors (TASR) expression was recently reported in neurological diseases. We explored the possible expression and regulation of selected OR and TASR genes in human orbitofrontal cortex of sporadic Alzheimer&rsquo;s disease (AD) and found that these are expressed and markedly downregulated at early stages. The expression pattern did not follow disease progression suggesting regulation through epigenetic mechanisms. We found an increase of global H3K9me3 levels and substantial enrichment of this repressive signature at ORs and TAS2Rs proximal promoter at early stages, ultimately lost at advanced stages. By mass spectrometry-based proteomic and further validation, we found that H3K9me3 interacts with MeCP2 at early stages and that this protein is increased in sporadic AD. Findings suggest MeCP2 might be implicated in OR and TAS2R genes expression regulation through interaction with H3K9me3, and as an early event, it may uncover a novel etiopathogenetic mechanism of sporadic AD.</p>',
			'date' => '2021-12-01',
			'pmid' => 'https://doi.org/10.21203%2Frs.3.rs-1098461%2Fv1',
			'doi' => '10.21203/rs.3.rs-1098461/v1',
			'modified' => '2022-05-23 09:51:36',
			'created' => '2022-05-19 10:41:50',
			'ProductsPublication' => array(
				[maximum depth reached]
			)
		)
	),
	'Testimonial' => array(),
	'Area' => array(),
	'SafetySheet' => array()
)
$country = 'US'
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	(int) 0 => 'CA',
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	(int) 3 => 'GB',
	(int) 4 => 'DK',
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	(int) 13 => 'CH',
	(int) 14 => 'AT',
	(int) 15 => 'ES',
	(int) 16 => 'IT',
	(int) 17 => 'PT'
)
$outsource = false
$other_formats = array()
$edit = ''
$testimonials = ''
$featured_testimonials = ''
$related_products = ''
$rrbs_service = array(
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	(int) 1 => (int) 1895
)
$chipseq_service = array(
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	(int) 2 => (int) 1836,
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	(int) 4 => (int) 1838,
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)
$labelize = object(Closure) {
	
}
$old_catalog_number = '<br/><small><span style="color:#CCC">(sp-052-050)</span></small>'
$country_code = 'US'
$label = '<img src="/img/banners/banner-customizer-back.png" alt=""/>'
$document = array(
	'id' => '480',
	'name' => 'Datasheet MeCP2 pAb-052-050',
	'description' => 'Datasheet description',
	'image_id' => null,
	'type' => 'Datasheet',
	'url' => 'files/products/antibodies/Datasheet_MeCP2_pAb-052-050.pdf',
	'slug' => 'datasheet-mecp2-pab-052-050',
	'meta_keywords' => null,
	'meta_description' => null,
	'modified' => '2015-07-07 11:47:44',
	'created' => '2015-07-07 11:47:44',
	'ProductsDocument' => array(
		'id' => '701',
		'product_id' => '2445',
		'document_id' => '480'
	)
)
$publication = array(
	'id' => '4275',
	'name' => 'Epigenetic Silencing of OR and TAS2R Genes Expression inHuman Orbitofrontal Cortex At Early Stages of SporadicAlzheimer’s Disease',
	'authors' => 'Alves Victoria Cunha et al.',
	'description' => '<p>Modulation of brain olfactory (OR) and taste receptors (TASR) expression was recently reported in neurological diseases. We explored the possible expression and regulation of selected OR and TASR genes in human orbitofrontal cortex of sporadic Alzheimer&rsquo;s disease (AD) and found that these are expressed and markedly downregulated at early stages. The expression pattern did not follow disease progression suggesting regulation through epigenetic mechanisms. We found an increase of global H3K9me3 levels and substantial enrichment of this repressive signature at ORs and TAS2Rs proximal promoter at early stages, ultimately lost at advanced stages. By mass spectrometry-based proteomic and further validation, we found that H3K9me3 interacts with MeCP2 at early stages and that this protein is increased in sporadic AD. Findings suggest MeCP2 might be implicated in OR and TAS2R genes expression regulation through interaction with H3K9me3, and as an early event, it may uncover a novel etiopathogenetic mechanism of sporadic AD.</p>',
	'date' => '2021-12-01',
	'pmid' => 'https://doi.org/10.21203%2Frs.3.rs-1098461%2Fv1',
	'doi' => '10.21203/rs.3.rs-1098461/v1',
	'modified' => '2022-05-23 09:51:36',
	'created' => '2022-05-19 10:41:50',
	'ProductsPublication' => array(
		'id' => '5712',
		'product_id' => '2445',
		'publication_id' => '4275'
	)
)
$externalLink = ' <a href="https://doi.org/10.21203%2Frs.3.rs-1098461%2Fv1" target="_blank"><i class="fa fa-external-link"></i></a>'
include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

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