| Datasheet Protease Inhibitor Mix kch-502-300 DATASHEET Datasheet description | Download |
This protease inhibitor Mix (P.I.) has been extensively validated in chromatin immunoprecipitation assays (ChIP). It contains inhibitors with a broad specificity for serine, cysteine, and acid proteases, and aminopeptidase.
| Datasheet Protease Inhibitor Mix kch-502-300 DATASHEET Datasheet description | Download |
| Protease Inhibitor Mix SDS US en | Download |
| Protease Inhibitor Mix SDS GB en | Download |
| Protease Inhibitor Mix SDS BE fr | Download |
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| Protease Inhibitor Mix SDS BE nl | Download |
 How to properly cite this product in your workDiagenode strongly recommends using this: Protease Inhibitor Mix, 300 µl (Diagenode Cat# C12010012). Click here to copy to clipboard. Using our products in your publication? Let us know! |
Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex. |
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nl', 'language' => 'nl', 'url' => 'files/SDS/Protease/SDS-C12010010_C12010011_C12010012-Protease_Inhibitor_Mix-BE-nl-GHS_2_0.pdf', 'countries' => 'BE', 'modified' => '2020-07-02 10:51:17', 'created' => '2020-07-02 10:51:17', 'ProductsSafetySheet' => array( 'id' => '1325', 'product_id' => '1941', 'safety_sheet_id' => '714' ) ) $publication = array( 'id' => '3878', 'name' => 'Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex.', 'authors' => 'Mestres I, Einsiedel M, Möller J, Cardoso de Toledo B', 'description' => '<p>Smad anchor for receptor activation (SARA, zfyve9) has been classically observed in early endosomes of different cells types where it regulates vesicular transport of proteins and membrane components. Very few other members of the zinc finger FYVE domain-containing family (zfyve) have different functions other than controlling membrane trafficking. By analyzing SARA localization throughout mouse embryonic brain development, we detected that besides the endosomal localization it also targets neuronal nuclei, specifically of the cortical layers V/VI. These findings were confirmed in human brain organoids. When evaluating neuronal cell lines, we found that SARA accumulates in nuclei of PC-12 cells, but not Neuro-2a, highlighting its specificity. SARA functions as a specific marker of the deep cortical layers until the first postnatal week. This temporal regulation corresponds with the final phases of neuron differentiation, such as soma ventral translocation and axonal targeting. In sum, here we report that SARA localization during brain development is temporarily regulated, and layer specific. This defined pattern helps in the identification of early born cortical neurons. We further show that other zfyve family members (FYCO1, WDFY3, Hrs) also distribute to nuclei of different cells in the brain cortex, which raises the possibility that this might be an extended feature within the protein family.</p>', 'date' => '2020-02-09', 'pmid' => 'http://www.pubmed.gov/32037591', 'doi' => '10.1002/cne.24881', 'modified' => '2020-03-20 17:35:34', 'created' => '2020-03-13 13:45:54', 'ProductsPublication' => array( 'id' => '4420', 'product_id' => '1941', 'publication_id' => '3878' ) ) $externalLink = ' <a href="http://www.pubmed.gov/32037591" target="_blank"><i class="fa fa-external-link"></i></a>'include - APP/View/Products/view.ctp, line 755 View::_evaluate() - CORE/Cake/View/View.php, line 971 View::_render() - CORE/Cake/View/View.php, line 933 View::render() - CORE/Cake/View/View.php, line 473 Controller::render() - CORE/Cake/Controller/Controller.php, line 963 ProductsController::slug() - APP/Controller/ProductsController.php, line 1052 ReflectionMethod::invokeArgs() - [internal], line ?? Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491 Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193 Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167 [main] - APP/webroot/index.php, line 118
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