| Datasheet Rat TSH2B pp1043 DATASHEET Datasheet description | Download |
The primer pair cat # pp-1043-050, -500 is specific to a CpG region of the TSH2B gene from rat. The primers are optimized to be used in quantitative polymerase chain reaction (qPCR).
| Datasheet Rat TSH2B pp1043 DATASHEET Datasheet description | Download |
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Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells. |
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Our results reveal the concept that epigenetic modulation of the mitochondrial pool prior to neurotrophic signaling dictates the efficiency of initiation of neuronal differentiation during the transition from progenitor to differentiating neuronal cells. The histone acetyltransferase CREB-binding protein plays a key role in regulating the mitochondrial biomass. By ChIP-seq analysis, we show that NaBt confers an H3K27ac epigenetic signature in several interconnected nodes of nuclear genes vital for neuronal differentiation and mitochondrial reprogramming. Collectively, our study reports a novel developmental epigenetic layer that couples mitochondrial biogenesis to neuronal differentiation.</p>', 'date' => '2018-03-02', 'pmid' => 'http://www.pubmed.gov/29500414', 'doi' => '10.1038/s41419-018-0396-1', 'modified' => '2019-02-15 21:21:45', 'created' => '2019-02-14 15:01:22', 'ProductsPublication' => array( 'id' => '3106', 'product_id' => '2597', 'publication_id' => '3463' ) ) $externalLink = ' <a href="http://www.pubmed.gov/29500414" target="_blank"><i class="fa fa-external-link"></i></a>'include - APP/View/Products/view.ctp, line 755 View::_evaluate() - CORE/Cake/View/View.php, line 971 View::_render() - CORE/Cake/View/View.php, line 933 View::render() - CORE/Cake/View/View.php, line 473 Controller::render() - CORE/Cake/Controller/Controller.php, line 963 ProductsController::slug() - APP/Controller/ProductsController.php, line 1052 ReflectionMethod::invokeArgs() - [internal], line ?? Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491 Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193 Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167 [main] - APP/webroot/index.php, line 118
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