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C2C2 monoclonal antibody

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Catalog Number

Format

Price

C15200249
(C15200241)

50 µg/50 µl

$465.00
Bulk order

Other format

C15200249-10

10 µg

Other name : Cas13a

Monoclonal antibody raised in mouse against the C2C2 protein from Leptotrichia shahii (CRISPR associated protein 13a) using a recombinant protein.

Lot	001
Concentration	1 µg/µl
Species reactivity	Leptotrichia shahii
Type	Monoclonal
Purity	Protein G purified monoclonal antibody
Host	Mouse
Storage Conditions	Store at -20°C; for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
Storage Buffer	PBS containing 0.05 % Na-azide
Precautions	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Applications	Suggested dilution/amount	References
Western blotting	1:1,000	Fig 1

Validation data

Figure 1. Western blot analysis using the Diagenode monoclonal antibody directed against C2C2
Western blot was performed on protein extracts from U2OS cells spiked with a partial recombinant C2C2 protein (430 AA, lane 1), using the Diagenode antibody against C2C2 (Cat. No. C15200249), diluted 1:1,000 in PBS-T containing 0.5% NFDM. Lane 2 shows the result of U2OS protein extracts only, used as negative control. The marker is shown on the left, the position of the C2C2 protein is indicated on the right.

資料
C2C2 monoclonal antibody datasheet DATASHEET
Monoclonal antibody raised in mouse against the C2C2 protein from Leptotrichia shahii (CRISPR ass... Download

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			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
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		),
		(int) 4 => array(
			'id' => '1586',
			'name' => 'C2C2 antibody SDS BE nl',
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			'url' => 'files/SDS/C2C2/SDS-C15200249-C2C2_Antibody-BE-nl-GHS_2_0.pdf',
			'countries' => 'BE',
			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
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		),
		(int) 5 => array(
			'id' => '1585',
			'name' => 'C2C2 antibody SDS BE fr',
			'language' => 'fr',
			'url' => 'files/SDS/C2C2/SDS-C15200249-C2C2_Antibody-BE-fr-GHS_2_0.pdf',
			'countries' => 'BE',
			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
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		(int) 6 => array(
			'id' => '1589',
			'name' => 'C2C2 antibody SDS FR fr',
			'language' => 'fr',
			'url' => 'files/SDS/C2C2/SDS-C15200249-C2C2_Antibody-FR-fr-GHS_2_0.pdf',
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			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
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		(int) 7 => array(
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			'name' => 'C2C2 antibody SDS ES es',
			'language' => 'es',
			'url' => 'files/SDS/C2C2/SDS-C15200249-C2C2_Antibody-ES-es-GHS_2_0.pdf',
			'countries' => 'ES',
			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
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	)
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$country = 'US'
$countries_allowed = array(
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		'info2' => '',
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		'info3' => '',
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	'name' => 'C2C2 Antibody (sample size)',
	'description' => '',
	'label1' => 'Validation data',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '10 µg',
	'catalog_number' => 'C15200249-10',
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}
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	'description' => '',
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$label = '<img src="/img/banners/banner-customizer-back.png" alt=""/>'
$application = array(
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	'position' => '10',
	'parent_id' => '40',
	'name' => 'WB',
	'description' => '<p><strong>Western blot</strong> : The quality of antibodies used in this technique is crucial for correct and specific protein identification. Diagenode offers huge selection of highly sensitive and specific western blot-validated antibodies.</p>
<p>Learn more about: <a href="https://www.diagenode.com/applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
<p><em></em>Check our selection of antibodies validated in Western blot.</p>',
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	'slug' => 'western-blot-antibodies',
	'meta_keywords' => ' Western Blot Antibodies ,western blot protocol,Western Blotting Products,Polyclonal antibodies ,monoclonal antibodies ',
	'meta_description' => 'Diagenode offers a wide range of antibodies and technical support for western blot applications',
	'meta_title' => ' Western Blot  - Monoclonal antibody - Polyclonal antibody  | Diagenode',
	'modified' => '2016-04-26 12:44:51',
	'created' => '2015-01-07 09:20:00',
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$applications = array(
	'id' => '19',
	'position' => '10',
	'parent_id' => '40',
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	'description' => '<p><strong>Western blot</strong> : The quality of antibodies used in this technique is crucial for correct and specific protein identification. Diagenode offers huge selection of highly sensitive and specific western blot-validated antibodies.</p>
<p>Learn more about: <a href="../applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
<p><em></em>Check our selection of antibodies validated in Western blot.</p>',
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	'tabular' => true,
	'slug' => 'western-blot-antibodies',
	'meta_keywords' => ' Western Blot Antibodies ,western blot protocol,Western Blotting Products,Polyclonal antibodies ,monoclonal antibodies ',
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	'meta_title' => ' Western Blot  - Monoclonal antibody - Polyclonal antibody  | Diagenode',
	'modified' => '2016-04-26 12:44:51',
	'created' => '2015-01-07 09:20:00',
	'locale' => 'jpn'
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$description = '<p><strong>Western blot</strong> : The quality of antibodies used in this technique is crucial for correct and specific protein identification. Diagenode offers huge selection of highly sensitive and specific western blot-validated antibodies.</p>
<p>Learn more about: <a href="../applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
<p><em></em>Check our selection of antibodies validated in Western blot.</p>'
$name = 'WB'
$document = array(
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	'name' => 'C2C2 monoclonal antibody datasheet',
	'description' => '<p>Monoclonal antibody raised in mouse against the C2C2 protein from Leptotrichia shahii (CRISPR associated protein 13a) using a recombinant protein.</p>
<p><strong>Other name : Cas13a</strong></p>',
	'image_id' => null,
	'type' => 'Datasheet',
	'url' => '../files/products/antibodies/Datasheet_C15200241_C2C2.pdf',
	'slug' => 'c2c2-monoclonal-antibody-tds',
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	'meta_description' => '',
	'modified' => '2018-09-13 14:49:32',
	'created' => '2018-09-13 14:49:32',
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	'countries' => 'ES',
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include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

Notice (8): Undefined variable: header [APP/View/Products/view.ctp, line 755]Code Context<!-- BEGIN: REQUEST_FORM MODAL -->
<div id="request_formModal" class="reveal-modal medium" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog">
    <?= $this->element('Forms/simple_form', array('solution_of_interest' => $solution_of_interest, 'header' => $header, 'message' => $message, 'campaign_id' => $campaign_id)) ?>
$viewFile = '/home/website-server/www/app/View/Products/view.ctp'
$dataForView = array(
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		(int) 0 => 'Gene editing'
	),
	'language' => 'jp',
	'meta_keywords' => '',
	'meta_description' => '',
	'meta_title' => 'C2C2 monoclonal antibody',
	'product' => array(
		'Product' => array(
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			'antibody_id' => '544',
			'name' => 'C2C2 monoclonal antibody',
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<p>Monoclonal antibody raised in mouse against the C2C2 protein from Leptotrichia shahii (CRISPR associated protein 13a) using a recombinant protein.</p>',
			'label1' => 'Validation data',
			'info1' => '<div class="row">
<div class="small-5 columns">
<p><img src="https://www.diagenode.com/img/product/antibodies/C15200241-WB.png" alt="WB" style="display: block; margin-left: auto; margin-right: auto;" width="167" height="290" /></p>
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<div class="small-7 columns">
<p><small><strong>Figure 1. Western blot analysis using the Diagenode monoclonal antibody directed against C2C2</strong><br />Western blot was performed on protein extracts from U2OS cells spiked with a partial recombinant C2C2 protein (430 AA, lane 1), using the Diagenode antibody against C2C2 (Cat. No. C15200249), diluted 1:1,000 in PBS-T containing 0.5% NFDM. Lane 2 shows the result of U2OS protein extracts only, used as negative control. The marker is shown on the left, the position of the C2C2 protein is indicated on the right.</small></p>
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			'name' => 'C2C2 monoclonal antibody',
			'description' => 'CRISPR systems are adaptable immune mechanisms which are present in many bacteria to protect themselves from foreign nucleic acids, such as viruses, transposable elements or plasmids. The CRISPR/Cas9 (CRISPR-associated protein 9nuclease) system from S. pyogenes was the first to be adapted for inducing sequence-specific double stranded breaks and targeted genome editing. This system is unique and flexible due to its dependence on RNA as the moiety that targets the nuclease to a desired DNA sequence and can be used to induce indel mutations, specific sequence replacements or insertions and large deletions or genomic rearrangements at any desired location in the genome. In addition, Cas9 can also be used to mediate upregulation of specific endogenous genes or to alter histone modifications or DNA methylation. Recently, a so-called class 2 type VI CRISPR system has been identified in Leptotrichia shahii. This CRISPR system is characterized by the presence of the single effector protein C2C2. C2C2 lacks homology to any known DNA nuclease domain but contains two Higher Eukaryotes and Prokaryotes Nucleotide-binding (HEPN) domains and is thought to function solely as an RNA-guided RNA-targeting CRISPR effector.',
			'clonality' => '',
			'isotype' => 'IgG1',
			'lot' => '001',
			'concentration' => '1 µg/µl',
			'reactivity' => 'Leptotrichia shahii',
			'type' => 'Monoclonal',
			'purity' => 'Protein G purified monoclonal antibody',
			'classification' => '',
			'application_table' => '<p><strong>&nbsp;</strong></p>
<table>
<tbody>
<tr>
<td width="158">
<p><strong>Applications</strong></p>
</td>
<td width="153">
<p><strong>Suggested dilution/amount</strong></p>
</td>
<td width="99">
<p><strong>References</strong></p>
</td>
</tr>
<tr>
<td width="158">
<p>Western blotting</p>
</td>
<td width="153">
<p>1:1,000</p>
</td>
<td width="99">
<p>Fig 1</p>
</td>
</tr>
</tbody>
</table>',
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$carrousel_order = array(
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$language = 'jp'
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$meta_description = ''
$meta_title = 'C2C2 monoclonal antibody'
$product = array(
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		'antibody_id' => '544',
		'name' => 'C2C2 monoclonal antibody',
		'description' => '<p><strong>Other name : Cas13a</strong></p>
<p>Monoclonal antibody raised in mouse against the C2C2 protein from Leptotrichia shahii (CRISPR associated protein 13a) using a recombinant protein.</p>',
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		'info1' => '<div class="row">
<div class="small-5 columns">
<p><img src="https://www.diagenode.com/img/product/antibodies/C15200241-WB.png" alt="WB" style="display: block; margin-left: auto; margin-right: auto;" width="167" height="290" /></p>
</div>
<div class="small-7 columns">
<p><small><strong>Figure 1. Western blot analysis using the Diagenode monoclonal antibody directed against C2C2</strong><br />Western blot was performed on protein extracts from U2OS cells spiked with a partial recombinant C2C2 protein (430 AA, lane 1), using the Diagenode antibody against C2C2 (Cat. No. C15200249), diluted 1:1,000 in PBS-T containing 0.5% NFDM. Lane 2 shows the result of U2OS protein extracts only, used as negative control. The marker is shown on the left, the position of the C2C2 protein is indicated on the right.</small></p>
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		'description' => 'CRISPR systems are adaptable immune mechanisms which are present in many bacteria to protect themselves from foreign nucleic acids, such as viruses, transposable elements or plasmids. The CRISPR/Cas9 (CRISPR-associated protein 9nuclease) system from S. pyogenes was the first to be adapted for inducing sequence-specific double stranded breaks and targeted genome editing. This system is unique and flexible due to its dependence on RNA as the moiety that targets the nuclease to a desired DNA sequence and can be used to induce indel mutations, specific sequence replacements or insertions and large deletions or genomic rearrangements at any desired location in the genome. In addition, Cas9 can also be used to mediate upregulation of specific endogenous genes or to alter histone modifications or DNA methylation. Recently, a so-called class 2 type VI CRISPR system has been identified in Leptotrichia shahii. This CRISPR system is characterized by the presence of the single effector protein C2C2. C2C2 lacks homology to any known DNA nuclease domain but contains two Higher Eukaryotes and Prokaryotes Nucleotide-binding (HEPN) domains and is thought to function solely as an RNA-guided RNA-targeting CRISPR effector.',
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<p><small><strong>Figure 1. Western blot analysis using the Diagenode monoclonal antibody directed against C2C2</strong><br />Western blot was performed on protein extracts from U2OS cells spiked with a partial recombinant C2C2 protein (430 AA, lane 1), using the Diagenode antibody against C2C2 (Cat. No. C15200249), diluted 1:1,000 in PBS-T containing 0.5% NFDM. Lane 2 shows the result of U2OS protein extracts only, used as negative control. The marker is shown on the left, the position of the C2C2 protein is indicated on the right.</small></p>
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$description = '<p><strong>Western blot</strong> : The quality of antibodies used in this technique is crucial for correct and specific protein identification. Diagenode offers huge selection of highly sensitive and specific western blot-validated antibodies.</p>
<p>Learn more about: <a href="../applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
<p><em></em>Check our selection of antibodies validated in Western blot.</p>'
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include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

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<p><strong>References</strong></p>
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<td width="158">
<p>Western blotting</p>
</td>
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<p>1:1,000</p>
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<td width="99">
<p>Fig 1</p>
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<p><small><strong>Figure 1. Western blot analysis using the Diagenode monoclonal antibody directed against C2C2</strong><br />Western blot was performed on protein extracts from U2OS cells spiked with a partial recombinant C2C2 protein (430 AA, lane 1), using the Diagenode antibody against C2C2 (Cat. No. C15200249), diluted 1:1,000 in PBS-T containing 0.5% NFDM. Lane 2 shows the result of U2OS protein extracts only, used as negative control. The marker is shown on the left, the position of the C2C2 protein is indicated on the right.</small></p>
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<p><strong>Suggested dilution/amount</strong></p>
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<p><strong>References</strong></p>
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<td width="158">
<p>Western blotting</p>
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<p>1:1,000</p>
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<td width="99">
<p>Fig 1</p>
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<p><small><strong>Figure 1. Western blot analysis using the Diagenode monoclonal antibody directed against C2C2</strong><br />Western blot was performed on protein extracts from U2OS cells spiked with a partial recombinant C2C2 protein (430 AA, lane 1), using the Diagenode antibody against C2C2 (Cat. No. C15200249), diluted 1:1,000 in PBS-T containing 0.5% NFDM. Lane 2 shows the result of U2OS protein extracts only, used as negative control. The marker is shown on the left, the position of the C2C2 protein is indicated on the right.</small></p>
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<p>Learn more about: <a href="https://www.diagenode.com/applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
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			'countries' => 'JP',
			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
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		),
		(int) 4 => array(
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			'name' => 'C2C2 antibody SDS BE nl',
			'language' => 'nl',
			'url' => 'files/SDS/C2C2/SDS-C15200249-C2C2_Antibody-BE-nl-GHS_2_0.pdf',
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			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
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		(int) 5 => array(
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			'name' => 'C2C2 antibody SDS BE fr',
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			'url' => 'files/SDS/C2C2/SDS-C15200249-C2C2_Antibody-BE-fr-GHS_2_0.pdf',
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			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
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		(int) 6 => array(
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			'name' => 'C2C2 antibody SDS FR fr',
			'language' => 'fr',
			'url' => 'files/SDS/C2C2/SDS-C15200249-C2C2_Antibody-FR-fr-GHS_2_0.pdf',
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			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
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		(int) 7 => array(
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			'language' => 'es',
			'url' => 'files/SDS/C2C2/SDS-C15200249-C2C2_Antibody-ES-es-GHS_2_0.pdf',
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			'modified' => '2021-08-30 17:13:51',
			'created' => '2021-08-30 17:13:51',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
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$country = 'US'
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		'info2' => '',
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	'description' => '',
	'label1' => 'Validation data',
	'info1' => '',
	'label2' => '',
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	'label3' => '',
	'info3' => '',
	'format' => '10 µg',
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$application = array(
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	'position' => '10',
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	'name' => 'WB',
	'description' => '<p><strong>Western blot</strong> : The quality of antibodies used in this technique is crucial for correct and specific protein identification. Diagenode offers huge selection of highly sensitive and specific western blot-validated antibodies.</p>
<p>Learn more about: <a href="https://www.diagenode.com/applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
<p><em></em>Check our selection of antibodies validated in Western blot.</p>',
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	'meta_keywords' => ' Western Blot Antibodies ,western blot protocol,Western Blotting Products,Polyclonal antibodies ,monoclonal antibodies ',
	'meta_description' => 'Diagenode offers a wide range of antibodies and technical support for western blot applications',
	'meta_title' => ' Western Blot  - Monoclonal antibody - Polyclonal antibody  | Diagenode',
	'modified' => '2016-04-26 12:44:51',
	'created' => '2015-01-07 09:20:00',
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$applications = array(
	'id' => '19',
	'position' => '10',
	'parent_id' => '40',
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	'description' => '<p><strong>Western blot</strong> : The quality of antibodies used in this technique is crucial for correct and specific protein identification. Diagenode offers huge selection of highly sensitive and specific western blot-validated antibodies.</p>
<p>Learn more about: <a href="../applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
<p><em></em>Check our selection of antibodies validated in Western blot.</p>',
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	'online' => true,
	'tabular' => true,
	'slug' => 'western-blot-antibodies',
	'meta_keywords' => ' Western Blot Antibodies ,western blot protocol,Western Blotting Products,Polyclonal antibodies ,monoclonal antibodies ',
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	'modified' => '2016-04-26 12:44:51',
	'created' => '2015-01-07 09:20:00',
	'locale' => 'jpn'
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$description = '<p><strong>Western blot</strong> : The quality of antibodies used in this technique is crucial for correct and specific protein identification. Diagenode offers huge selection of highly sensitive and specific western blot-validated antibodies.</p>
<p>Learn more about: <a href="../applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
<p><em></em>Check our selection of antibodies validated in Western blot.</p>'
$name = 'WB'
$document = array(
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	'name' => 'C2C2 monoclonal antibody datasheet',
	'description' => '<p>Monoclonal antibody raised in mouse against the C2C2 protein from Leptotrichia shahii (CRISPR associated protein 13a) using a recombinant protein.</p>
<p><strong>Other name : Cas13a</strong></p>',
	'image_id' => null,
	'type' => 'Datasheet',
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	'meta_description' => '',
	'modified' => '2018-09-13 14:49:32',
	'created' => '2018-09-13 14:49:32',
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	'countries' => 'ES',
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include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

Notice (8): Undefined variable: campaign_id [APP/View/Products/view.ctp, line 755]Code Context<!-- BEGIN: REQUEST_FORM MODAL -->
<div id="request_formModal" class="reveal-modal medium" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog">
    <?= $this->element('Forms/simple_form', array('solution_of_interest' => $solution_of_interest, 'header' => $header, 'message' => $message, 'campaign_id' => $campaign_id)) ?>
$viewFile = '/home/website-server/www/app/View/Products/view.ctp'
$dataForView = array(
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	'language' => 'jp',
	'meta_keywords' => '',
	'meta_description' => '',
	'meta_title' => 'C2C2 monoclonal antibody',
	'product' => array(
		'Product' => array(
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			'antibody_id' => '544',
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<p>Monoclonal antibody raised in mouse against the C2C2 protein from Leptotrichia shahii (CRISPR associated protein 13a) using a recombinant protein.</p>',
			'label1' => 'Validation data',
			'info1' => '<div class="row">
<div class="small-5 columns">
<p><img src="https://www.diagenode.com/img/product/antibodies/C15200241-WB.png" alt="WB" style="display: block; margin-left: auto; margin-right: auto;" width="167" height="290" /></p>
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<div class="small-7 columns">
<p><small><strong>Figure 1. Western blot analysis using the Diagenode monoclonal antibody directed against C2C2</strong><br />Western blot was performed on protein extracts from U2OS cells spiked with a partial recombinant C2C2 protein (430 AA, lane 1), using the Diagenode antibody against C2C2 (Cat. No. C15200249), diluted 1:1,000 in PBS-T containing 0.5% NFDM. Lane 2 shows the result of U2OS protein extracts only, used as negative control. The marker is shown on the left, the position of the C2C2 protein is indicated on the right.</small></p>
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			'created' => '2018-09-10 15:28:50',
			'locale' => 'jpn'
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		'Antibody' => array(
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			'name' => 'C2C2 monoclonal antibody',
			'description' => 'CRISPR systems are adaptable immune mechanisms which are present in many bacteria to protect themselves from foreign nucleic acids, such as viruses, transposable elements or plasmids. The CRISPR/Cas9 (CRISPR-associated protein 9nuclease) system from S. pyogenes was the first to be adapted for inducing sequence-specific double stranded breaks and targeted genome editing. This system is unique and flexible due to its dependence on RNA as the moiety that targets the nuclease to a desired DNA sequence and can be used to induce indel mutations, specific sequence replacements or insertions and large deletions or genomic rearrangements at any desired location in the genome. In addition, Cas9 can also be used to mediate upregulation of specific endogenous genes or to alter histone modifications or DNA methylation. Recently, a so-called class 2 type VI CRISPR system has been identified in Leptotrichia shahii. This CRISPR system is characterized by the presence of the single effector protein C2C2. C2C2 lacks homology to any known DNA nuclease domain but contains two Higher Eukaryotes and Prokaryotes Nucleotide-binding (HEPN) domains and is thought to function solely as an RNA-guided RNA-targeting CRISPR effector.',
			'clonality' => '',
			'isotype' => 'IgG1',
			'lot' => '001',
			'concentration' => '1 µg/µl',
			'reactivity' => 'Leptotrichia shahii',
			'type' => 'Monoclonal',
			'purity' => 'Protein G purified monoclonal antibody',
			'classification' => '',
			'application_table' => '<p><strong>&nbsp;</strong></p>
<table>
<tbody>
<tr>
<td width="158">
<p><strong>Applications</strong></p>
</td>
<td width="153">
<p><strong>Suggested dilution/amount</strong></p>
</td>
<td width="99">
<p><strong>References</strong></p>
</td>
</tr>
<tr>
<td width="158">
<p>Western blotting</p>
</td>
<td width="153">
<p>1:1,000</p>
</td>
<td width="99">
<p>Fig 1</p>
</td>
</tr>
</tbody>
</table>',
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			'precautions' => 'This product is for research use only. Not for use in diagnostic or therapeutic procedures.',
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			'meta_keywords' => 'C2C2 monoclonal antibody',
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$carrousel_order = array(
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$language = 'jp'
$meta_keywords = ''
$meta_description = ''
$meta_title = 'C2C2 monoclonal antibody'
$product = array(
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		'antibody_id' => '544',
		'name' => 'C2C2 monoclonal antibody',
		'description' => '<p><strong>Other name : Cas13a</strong></p>
<p>Monoclonal antibody raised in mouse against the C2C2 protein from Leptotrichia shahii (CRISPR associated protein 13a) using a recombinant protein.</p>',
		'label1' => 'Validation data',
		'info1' => '<div class="row">
<div class="small-5 columns">
<p><img src="https://www.diagenode.com/img/product/antibodies/C15200241-WB.png" alt="WB" style="display: block; margin-left: auto; margin-right: auto;" width="167" height="290" /></p>
</div>
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<p><small><strong>Figure 1. Western blot analysis using the Diagenode monoclonal antibody directed against C2C2</strong><br />Western blot was performed on protein extracts from U2OS cells spiked with a partial recombinant C2C2 protein (430 AA, lane 1), using the Diagenode antibody against C2C2 (Cat. No. C15200249), diluted 1:1,000 in PBS-T containing 0.5% NFDM. Lane 2 shows the result of U2OS protein extracts only, used as negative control. The marker is shown on the left, the position of the C2C2 protein is indicated on the right.</small></p>
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		'application_id' => '19'
	)
)
$slugs = array(
	(int) 0 => 'western-blot-antibodies'
)
$applications = array(
	'id' => '19',
	'position' => '10',
	'parent_id' => '40',
	'name' => 'WB',
	'description' => '<p><strong>Western blot</strong> : The quality of antibodies used in this technique is crucial for correct and specific protein identification. Diagenode offers huge selection of highly sensitive and specific western blot-validated antibodies.</p>
<p>Learn more about: <a href="../applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
<p><em></em>Check our selection of antibodies validated in Western blot.</p>',
	'in_footer' => false,
	'in_menu' => false,
	'online' => true,
	'tabular' => true,
	'slug' => 'western-blot-antibodies',
	'meta_keywords' => ' Western Blot Antibodies ,western blot protocol,Western Blotting Products,Polyclonal antibodies ,monoclonal antibodies ',
	'meta_description' => 'Diagenode offers a wide range of antibodies and technical support for western blot applications',
	'meta_title' => ' Western Blot  - Monoclonal antibody - Polyclonal antibody  | Diagenode',
	'modified' => '2016-04-26 12:44:51',
	'created' => '2015-01-07 09:20:00',
	'locale' => 'jpn'
)
$description = '<p><strong>Western blot</strong> : The quality of antibodies used in this technique is crucial for correct and specific protein identification. Diagenode offers huge selection of highly sensitive and specific western blot-validated antibodies.</p>
<p>Learn more about: <a href="../applications/western-blot">Loading control, MW marker visualization</a><em>. <br /></em></p>
<p><em></em>Check our selection of antibodies validated in Western blot.</p>'
$name = 'WB'
$document = array(
	'id' => '1027',
	'name' => 'C2C2 monoclonal antibody datasheet',
	'description' => '<p>Monoclonal antibody raised in mouse against the C2C2 protein from Leptotrichia shahii (CRISPR associated protein 13a) using a recombinant protein.</p>
<p><strong>Other name : Cas13a</strong></p>',
	'image_id' => null,
	'type' => 'Datasheet',
	'url' => '../files/products/antibodies/Datasheet_C15200241_C2C2.pdf',
	'slug' => 'c2c2-monoclonal-antibody-tds',
	'meta_keywords' => '',
	'meta_description' => '',
	'modified' => '2018-09-13 14:49:32',
	'created' => '2018-09-13 14:49:32',
	'ProductsDocument' => array(
		'id' => '2672',
		'product_id' => '2994',
		'document_id' => '1027'
	)
)
$sds = array(
	'id' => '1588',
	'name' => 'C2C2 antibody SDS ES es',
	'language' => 'es',
	'url' => 'files/SDS/C2C2/SDS-C15200249-C2C2_Antibody-ES-es-GHS_2_0.pdf',
	'countries' => 'ES',
	'modified' => '2021-08-30 17:13:51',
	'created' => '2021-08-30 17:13:51',
	'ProductsSafetySheet' => array(
		'id' => '2766',
		'product_id' => '2994',
		'safety_sheet_id' => '1588'
	)
)
include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

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C2C2 monoclonal antibody

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