下载

Spatial tissue proteomics of FFPE specimen using the Bioruptor® for sample preparation

Thanks to the excellent preservation of morphological features, formalin fixed and paraffin embedded (FFPE) tissues are an invaluable resource for spatial tissue proteomics. At the same time, due to the chemical crosslinking, it is extremely difficult to lyse such samples and solubilize proteins for deep proteomic analysis. A team of researchers from the EMBL in Heidelberg led by Martin Beck, Stephan Singer (University Hospital Heidelberg and University of Greifswald) and Alessandro Ori (Leibniz Institute on Aging – Fritz Lipmann Institute) has developed a strategy that utilizes the Bioruptor Plus in combination with heat-induced reversing of formalin fixation to enhance the efficient protein extraction from FFPE tissues [1]. This enables the ultrasensitive and highly reproducible proteomic analysis of microdissected FFPE specimen with high spatial resolution.

很高兴再次见到您！

Set country preference

To ensure you see the information most relevant to you, please select your country. Please note that your browser will need to be configured to accept cookies.

Diagenode will process your personal data in strict accordance with its privacy policy. This will include sending you updates about us, our products, and resources we think would be of interest to you.

Email verification^*

Spatial tissue proteomics of FFPE specimen using the Bioruptor® for sample preparation

相关产品

Bioruptor® Plus sonication device

活动