Novel role of UHRF1 in the epigenetic repression of the latent HIV-1. Verdikt R. et al. BACKGROUND: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing agents (LRAs) have been reported to present variable ex vivo potencies. Here,... |
H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1. Monnier P, Martinet C, Pontis J, Stancheva I, Ait-Si-Ali S, Dandolo L The H19 gene controls the expression of several genes within the Imprinted Gene Network (IGN), involved in growth control of the embryo. However, the underlying mechanisms of this control remain elusive. Here, we identified the methyl-CpG-binding domain protein 1 MBD1 as a physical and functional partner of the H19 ... |