Human ChIP-seq grade c-fos promoter primer pair

Catalog Number

Format

Price

C17011004-50
(pp-1004-050)

50 µl

$35.00

Other format

C17011004-500

500 µl

This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR® Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).

Documents
Datasheet Human cfos promoter pp1004 DATASHEET
Datasheet description Download

Publications

How to properly cite this product in your work

Diagenode strongly recommends using this: Human ChIP-seq grade c-fos promoter primer pair (Diagenode Cat# C17011004-50). Click here to copy to clipboard.

Using our products in your publication? Let us know!

Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells
Dagdemir A et al.
BACKGROUND/AIM: Numerous studies have shown that breast cancer and epigenetic mechanisms have a very powerful interactive relation. The MCF7 cell line, representative of luminal subtype and the MDA-MB 231 cell line representative of mesenchymal-like subtype were treated respectively with a Histone Methyl Transferas...

Notice (8): Undefined variable: solution_of_interest [APP/View/Products/view.ctp, line 755]Code Context<!-- BEGIN: REQUEST_FORM MODAL -->
<div id="request_formModal" class="reveal-modal medium" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog">
    <?= $this->element('Forms/simple_form', array('solution_of_interest' => $solution_of_interest, 'header' => $header, 'message' => $message, 'campaign_id' => $campaign_id)) ?>
$viewFile = '/home/website-server/www/app/View/Products/view.ctp'
$dataForView = array(
	'language' => 'en',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'product' => array(
		'Product' => array(
			'id' => '2517',
			'antibody_id' => null,
			'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
			'label1' => '',
			'info1' => '',
			'label2' => '',
			'info2' => '',
			'label3' => '',
			'info3' => '',
			'format' => '50 µl',
			'catalog_number' => 'C17011004-50',
			'old_catalog_number' => 'pp-1004-050',
			'sf_code' => 'C17011004-D001-000014',
			'type' => 'FRE',
			'search_order' => '04-undefined',
			'price_EUR' => '60',
			'price_USD' => '35',
			'price_GBP' => '60',
			'price_JPY' => '9400',
			'price_CNY' => '',
			'price_AUD' => '88',
			'country' => 'ALL',
			'except_countries' => 'None',
			'quote' => false,
			'in_stock' => false,
			'featured' => true,
			'no_promo' => false,
			'online' => true,
			'master' => true,
			'last_datasheet_update' => '0000-00-00',
			'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
			'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'meta_keywords' => '',
			'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'modified' => '2016-10-21 08:17:25',
			'created' => '2015-06-29 14:08:20',
			'locale' => 'eng'
		),
		'Antibody' => array(
			'host' => '*****',
			'id' => null,
			'name' => null,
			'description' => null,
			'clonality' => null,
			'isotype' => null,
			'lot' => null,
			'concentration' => null,
			'reactivity' => null,
			'type' => null,
			'purity' => null,
			'classification' => null,
			'application_table' => null,
			'storage_conditions' => null,
			'storage_buffer' => null,
			'precautions' => null,
			'uniprot_acc' => null,
			'slug' => null,
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => null,
			'created' => null,
			'select_label' => null
		),
		'Slave' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Group' => array(
			'Group' => array(
				[maximum depth reached]
			),
			'Master' => array(
				[maximum depth reached]
			),
			'Product' => array(
				[maximum depth reached]
			)
		),
		'Related' => array(),
		'Application' => array(),
		'Category' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Document' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Feature' => array(),
		'Image' => array(),
		'Promotion' => array(),
		'Protocol' => array(),
		'Publication' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Testimonial' => array(),
		'Area' => array(),
		'SafetySheet' => array(
			(int) 0 => array(
				[maximum depth reached]
			),
			(int) 1 => array(
				[maximum depth reached]
			),
			(int) 2 => array(
				[maximum depth reached]
			),
			(int) 3 => array(
				[maximum depth reached]
			),
			(int) 4 => array(
				[maximum depth reached]
			),
			(int) 5 => array(
				[maximum depth reached]
			),
			(int) 6 => array(
				[maximum depth reached]
			),
			(int) 7 => array(
				[maximum depth reached]
			)
		)
	),
	'meta_canonical' => 'https://www.diagenode.com/en/p/human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul'
)
$language = 'en'
$meta_keywords = ''
$meta_description = 'Human  ChIP-seq grade c-fos promoter primer pair'
$meta_title = 'Human  ChIP-seq grade c-fos promoter primer pair'
$product = array(
	'Product' => array(
		'id' => '2517',
		'antibody_id' => null,
		'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
		'label1' => '',
		'info1' => '',
		'label2' => '',
		'info2' => '',
		'label3' => '',
		'info3' => '',
		'format' => '50 µl',
		'catalog_number' => 'C17011004-50',
		'old_catalog_number' => 'pp-1004-050',
		'sf_code' => 'C17011004-D001-000014',
		'type' => 'FRE',
		'search_order' => '04-undefined',
		'price_EUR' => '60',
		'price_USD' => '35',
		'price_GBP' => '60',
		'price_JPY' => '9400',
		'price_CNY' => '',
		'price_AUD' => '88',
		'country' => 'ALL',
		'except_countries' => 'None',
		'quote' => false,
		'in_stock' => false,
		'featured' => true,
		'no_promo' => false,
		'online' => true,
		'master' => true,
		'last_datasheet_update' => '0000-00-00',
		'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
		'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'meta_keywords' => '',
		'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'modified' => '2016-10-21 08:17:25',
		'created' => '2015-06-29 14:08:20',
		'locale' => 'eng'
	),
	'Antibody' => array(
		'host' => '*****',
		'id' => null,
		'name' => null,
		'description' => null,
		'clonality' => null,
		'isotype' => null,
		'lot' => null,
		'concentration' => null,
		'reactivity' => null,
		'type' => null,
		'purity' => null,
		'classification' => null,
		'application_table' => null,
		'storage_conditions' => null,
		'storage_buffer' => null,
		'precautions' => null,
		'uniprot_acc' => null,
		'slug' => null,
		'meta_keywords' => null,
		'meta_description' => null,
		'modified' => null,
		'created' => null,
		'select_label' => null
	),
	'Slave' => array(
		(int) 0 => array(
			'id' => '118',
			'name' => 'C17011004',
			'product_id' => '2517',
			'modified' => '2016-02-19 21:27:26',
			'created' => '2016-02-19 21:27:26'
		)
	),
	'Group' => array(
		'Group' => array(
			'id' => '118',
			'name' => 'C17011004',
			'product_id' => '2517',
			'modified' => '2016-02-19 21:27:26',
			'created' => '2016-02-19 21:27:26'
		),
		'Master' => array(
			'id' => '2517',
			'antibody_id' => null,
			'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
			'label1' => '',
			'info1' => '',
			'label2' => '',
			'info2' => '',
			'label3' => '',
			'info3' => '',
			'format' => '50 µl',
			'catalog_number' => 'C17011004-50',
			'old_catalog_number' => 'pp-1004-050',
			'sf_code' => 'C17011004-D001-000014',
			'type' => 'FRE',
			'search_order' => '04-undefined',
			'price_EUR' => '60',
			'price_USD' => '35',
			'price_GBP' => '60',
			'price_JPY' => '9400',
			'price_CNY' => '',
			'price_AUD' => '88',
			'country' => 'ALL',
			'except_countries' => 'None',
			'quote' => false,
			'in_stock' => false,
			'featured' => true,
			'no_promo' => false,
			'online' => true,
			'master' => true,
			'last_datasheet_update' => '0000-00-00',
			'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
			'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'meta_keywords' => '',
			'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'modified' => '2016-10-21 08:17:25',
			'created' => '2015-06-29 14:08:20'
		),
		'Product' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		)
	),
	'Related' => array(),
	'Application' => array(),
	'Category' => array(
		(int) 0 => array(
			'id' => '69',
			'position' => '1',
			'parent_id' => '35',
			'name' => 'Human',
			'description' => '<p>Primer pairs - Human</p>',
			'no_promo' => false,
			'in_menu' => false,
			'online' => true,
			'tabular' => true,
			'hide' => false,
			'all_format' => false,
			'is_antibody' => false,
			'slug' => 'primer-pairs-human',
			'cookies_tag_id' => null,
			'meta_keywords' => 'Primer pairs, human, ChIP-seq grade',
			'meta_description' => 'Diagenode offers Primer pairs for Human ChIP-seq grade',
			'meta_title' => 'Primer pairs - Human | Diagenode',
			'modified' => '2016-10-21 08:00:50',
			'created' => '2015-07-23 15:38:42',
			'ProductsCategory' => array(
				[maximum depth reached]
			),
			'CookiesTag' => array([maximum depth reached])
		)
	),
	'Document' => array(
		(int) 0 => array(
			'id' => '254',
			'name' => 'Datasheet Human cfos promoter pp1004',
			'description' => 'Datasheet description',
			'image_id' => null,
			'type' => 'Datasheet',
			'url' => 'files/products/reagents/primer_pairs/Datasheet_Human_cfos_promoter_pp1004.pdf',
			'slug' => 'datasheet-human-cfos-promoter-pp1004',
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => '2015-07-07 11:47:43',
			'created' => '2015-07-07 11:47:43',
			'ProductsDocument' => array(
				[maximum depth reached]
			)
		)
	),
	'Feature' => array(),
	'Image' => array(),
	'Promotion' => array(),
	'Protocol' => array(),
	'Publication' => array(
		(int) 0 => array(
			'id' => '2980',
			'name' => 'Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells',
			'authors' => 'Dagdemir A et al.',
			'description' => '<h4>BACKGROUND/AIM:</h4>
<p><abstracttext label="BACKGROUND/AIM" nlmcategory="OBJECTIVE">Numerous studies have shown that breast cancer and epigenetic mechanisms have a very powerful interactive relation. The MCF7 cell line, representative of luminal subtype and the MDA-MB 231 cell line representative of mesenchymal-like subtype were treated respectively with a Histone Methyl Transferase Inhibitors (HMTi), 3-Deazaneplanocin hydrochloride (DZNep), two histone deacetylase inhibitors (HDACi), sodium butyrate (NaBu), and suberoylanilide hydroxamic acid (SAHA) for 48 h.</abstracttext></p>
<h4>MATERIALS AND METHODS:</h4>
<p><abstracttext label="MATERIALS AND METHODS" nlmcategory="METHODS">Chromatin immunoprecipitation (ChIP) was used to observe HDACis (SAHA and NaBu) and HMTi (DZNep) impact on histones and more specifically on H3K27me3, H3K9ac and H3K4ac marks with Q-PCR analysis of BRCA1, SRC3 and P300 genes. Furthermore, the HDACi and HMTi effects on mRNA and protein expression of BRCA1, SRC3 and P300 genes were checked. In addition, statistical analyses were used.</abstracttext></p>
<h4>RESULTS:</h4>
<p><abstracttext label="RESULTS" nlmcategory="RESULTS">In the MCF7 luminal subtype with positive ER, H3k4ac was significantly increased on BRCA1 with SAHA. On the contrary, in the MDA-MB 231 breast cancer cell line, representative of mesenchymal-like subtype with negative estrogen receptor, HDACis had no effect. Also, DZNEP decreased significantly H3K27me3 on BRCA1 in MDA-MB 231. Besides, on SRC3, a significant increase for H3K4ac was obtained in MCF7 treated with SAHA. And DZNEP had no effect in MCF7. Also, in MDA-MB 231 treated with DZNEP, H3K27me3 significantly decreased on SRC3 while H3K4ac was significantly increased in MDA-MB-231 treated with SAHA or NaBu for P300.</abstracttext></p>
<h4>CONCLUSION:</h4>
<p><abstracttext label="CONCLUSION" nlmcategory="CONCLUSIONS">Luminal and mesenchymal-like breast cancer subtype cell lines seemed to act differently to HDACis (SAHA and NaBu) or HMTi (DZNEP) treatments.</abstracttext></p>',
			'date' => '2016-07-01',
			'pmid' => 'http://www.ncbi.nlm.nih.gov/pubmed/27365379',
			'doi' => '',
			'modified' => '2016-07-12 12:50:21',
			'created' => '2016-07-12 12:46:04',
			'ProductsPublication' => array(
				[maximum depth reached]
			)
		)
	),
	'Testimonial' => array(),
	'Area' => array(),
	'SafetySheet' => array(
		(int) 0 => array(
			'id' => '270',
			'name' => 'c-fos Promoter Primer Pair SDS GB en',
			'language' => 'en',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-GB-en-GHS_1_0.pdf',
			'countries' => 'GB',
			'modified' => '2020-06-09 10:33:07',
			'created' => '2020-06-09 10:33:07',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 1 => array(
			'id' => '272',
			'name' => 'c-fos Promoter Primer Pair SDS US en',
			'language' => 'en',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-US-en-GHS_1_0.pdf',
			'countries' => 'US',
			'modified' => '2020-06-09 10:34:22',
			'created' => '2020-06-09 10:34:22',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 2 => array(
			'id' => '267',
			'name' => 'c-fos Promoter Primer Pair SDS DE de',
			'language' => 'de',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-DE-de-GHS_1_0.pdf',
			'countries' => 'DE',
			'modified' => '2020-06-09 10:27:14',
			'created' => '2020-06-09 10:27:14',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 3 => array(
			'id' => '271',
			'name' => 'c-fos Promoter Primer Pair SDS JP ja',
			'language' => 'ja',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-JP-ja-GHS_2_0.pdf',
			'countries' => 'JP',
			'modified' => '2020-06-09 10:33:45',
			'created' => '2020-06-09 10:33:45',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 4 => array(
			'id' => '266',
			'name' => 'c-fos Promoter Primer Pair SDS BE nl',
			'language' => 'nl',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-BE-nl-GHS_1_0.pdf',
			'countries' => 'BE',
			'modified' => '2020-06-09 10:25:59',
			'created' => '2020-06-09 10:25:59',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 5 => array(
			'id' => '265',
			'name' => 'c-fos Promoter Primer Pair SDS BE fr',
			'language' => 'fr',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-BE-fr-GHS_1_0.pdf',
			'countries' => 'BE',
			'modified' => '2020-06-09 10:24:34',
			'created' => '2020-06-09 10:24:34',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 6 => array(
			'id' => '269',
			'name' => 'c-fos Promoter Primer Pair SDS FR fr',
			'language' => 'fr',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-FR-fr-GHS_1_0.pdf',
			'countries' => 'FR',
			'modified' => '2020-06-09 10:29:06',
			'created' => '2020-06-09 10:29:06',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 7 => array(
			'id' => '268',
			'name' => 'c-fos Promoter Primer Pair SDS ES es',
			'language' => 'es',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-ES-es-GHS_1_0.pdf',
			'countries' => 'ES',
			'modified' => '2020-06-09 10:28:17',
			'created' => '2020-06-09 10:28:17',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		)
	)
)
$meta_canonical = 'https://www.diagenode.com/en/p/human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul'
$country = 'US'
$countries_allowed = array(
	(int) 0 => 'CA',
	(int) 1 => 'US',
	(int) 2 => 'IE',
	(int) 3 => 'GB',
	(int) 4 => 'DK',
	(int) 5 => 'NO',
	(int) 6 => 'SE',
	(int) 7 => 'FI',
	(int) 8 => 'NL',
	(int) 9 => 'BE',
	(int) 10 => 'LU',
	(int) 11 => 'FR',
	(int) 12 => 'DE',
	(int) 13 => 'CH',
	(int) 14 => 'AT',
	(int) 15 => 'ES',
	(int) 16 => 'IT',
	(int) 17 => 'PT'
)
$outsource = false
$other_formats = array(
	(int) 0 => array(
		'id' => '2518',
		'antibody_id' => null,
		'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
		'label1' => '',
		'info1' => '',
		'label2' => '',
		'info2' => '',
		'label3' => '',
		'info3' => '',
		'format' => '500 µl',
		'catalog_number' => 'C17011004-500',
		'old_catalog_number' => 'pp-1004-500',
		'sf_code' => 'C17011004-D001-000015',
		'type' => 'FRE',
		'search_order' => '04-undefined',
		'price_EUR' => '115',
		'price_USD' => '100',
		'price_GBP' => '105',
		'price_JPY' => '18015',
		'price_CNY' => '',
		'price_AUD' => '250',
		'country' => 'ALL',
		'except_countries' => 'None',
		'quote' => false,
		'in_stock' => false,
		'featured' => true,
		'no_promo' => false,
		'online' => true,
		'master' => false,
		'last_datasheet_update' => '0000-00-00',
		'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
		'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'meta_keywords' => '',
		'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'modified' => '2016-02-19 21:27:54',
		'created' => '2015-06-29 14:08:20',
		'ProductsGroup' => array(
			'id' => '129',
			'product_id' => '2518',
			'group_id' => '118'
		)
	)
)
$pro = array(
	'id' => '2518',
	'antibody_id' => null,
	'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
	'label1' => '',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '500 µl',
	'catalog_number' => 'C17011004-500',
	'old_catalog_number' => 'pp-1004-500',
	'sf_code' => 'C17011004-D001-000015',
	'type' => 'FRE',
	'search_order' => '04-undefined',
	'price_EUR' => '115',
	'price_USD' => '100',
	'price_GBP' => '105',
	'price_JPY' => '18015',
	'price_CNY' => '',
	'price_AUD' => '250',
	'country' => 'ALL',
	'except_countries' => 'None',
	'quote' => false,
	'in_stock' => false,
	'featured' => true,
	'no_promo' => false,
	'online' => true,
	'master' => false,
	'last_datasheet_update' => '0000-00-00',
	'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'modified' => '2016-02-19 21:27:54',
	'created' => '2015-06-29 14:08:20',
	'ProductsGroup' => array(
		'id' => '129',
		'product_id' => '2518',
		'group_id' => '118'
	)
)
$edit = ''
$testimonials = ''
$featured_testimonials = ''
$related_products = ''
$rrbs_service = array(
	(int) 0 => (int) 1894,
	(int) 1 => (int) 1895
)
$chipseq_service = array(
	(int) 0 => (int) 2683,
	(int) 1 => (int) 1835,
	(int) 2 => (int) 1836,
	(int) 3 => (int) 2684,
	(int) 4 => (int) 1838,
	(int) 5 => (int) 1839,
	(int) 6 => (int) 1856
)
$labelize = object(Closure) {
	
}
$old_catalog_number = ' <span style="color:#CCC">(pp-1004-500)</span>'
$country_code = 'US'
$other_format = array(
	'id' => '2518',
	'antibody_id' => null,
	'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
	'label1' => '',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '500 µl',
	'catalog_number' => 'C17011004-500',
	'old_catalog_number' => 'pp-1004-500',
	'sf_code' => 'C17011004-D001-000015',
	'type' => 'FRE',
	'search_order' => '04-undefined',
	'price_EUR' => '115',
	'price_USD' => '100',
	'price_GBP' => '105',
	'price_JPY' => '18015',
	'price_CNY' => '',
	'price_AUD' => '250',
	'country' => 'ALL',
	'except_countries' => 'None',
	'quote' => false,
	'in_stock' => false,
	'featured' => true,
	'no_promo' => false,
	'online' => true,
	'master' => false,
	'last_datasheet_update' => '0000-00-00',
	'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'modified' => '2016-02-19 21:27:54',
	'created' => '2015-06-29 14:08:20',
	'ProductsGroup' => array(
		'id' => '129',
		'product_id' => '2518',
		'group_id' => '118'
	)
)
$label = '<img src="/img/banners/banner-customizer-back.png" alt=""/>'
$document = array(
	'id' => '254',
	'name' => 'Datasheet Human cfos promoter pp1004',
	'description' => 'Datasheet description',
	'image_id' => null,
	'type' => 'Datasheet',
	'url' => 'files/products/reagents/primer_pairs/Datasheet_Human_cfos_promoter_pp1004.pdf',
	'slug' => 'datasheet-human-cfos-promoter-pp1004',
	'meta_keywords' => null,
	'meta_description' => null,
	'modified' => '2015-07-07 11:47:43',
	'created' => '2015-07-07 11:47:43',
	'ProductsDocument' => array(
		'id' => '586',
		'product_id' => '2517',
		'document_id' => '254'
	)
)
$sds = array(
	'id' => '268',
	'name' => 'c-fos Promoter Primer Pair SDS ES es',
	'language' => 'es',
	'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-ES-es-GHS_1_0.pdf',
	'countries' => 'ES',
	'modified' => '2020-06-09 10:28:17',
	'created' => '2020-06-09 10:28:17',
	'ProductsSafetySheet' => array(
		'id' => '502',
		'product_id' => '2517',
		'safety_sheet_id' => '268'
	)
)
$publication = array(
	'id' => '2980',
	'name' => 'Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells',
	'authors' => 'Dagdemir A et al.',
	'description' => '<h4>BACKGROUND/AIM:</h4>
<p><abstracttext label="BACKGROUND/AIM" nlmcategory="OBJECTIVE">Numerous studies have shown that breast cancer and epigenetic mechanisms have a very powerful interactive relation. The MCF7 cell line, representative of luminal subtype and the MDA-MB 231 cell line representative of mesenchymal-like subtype were treated respectively with a Histone Methyl Transferase Inhibitors (HMTi), 3-Deazaneplanocin hydrochloride (DZNep), two histone deacetylase inhibitors (HDACi), sodium butyrate (NaBu), and suberoylanilide hydroxamic acid (SAHA) for 48 h.</abstracttext></p>
<h4>MATERIALS AND METHODS:</h4>
<p><abstracttext label="MATERIALS AND METHODS" nlmcategory="METHODS">Chromatin immunoprecipitation (ChIP) was used to observe HDACis (SAHA and NaBu) and HMTi (DZNep) impact on histones and more specifically on H3K27me3, H3K9ac and H3K4ac marks with Q-PCR analysis of BRCA1, SRC3 and P300 genes. Furthermore, the HDACi and HMTi effects on mRNA and protein expression of BRCA1, SRC3 and P300 genes were checked. In addition, statistical analyses were used.</abstracttext></p>
<h4>RESULTS:</h4>
<p><abstracttext label="RESULTS" nlmcategory="RESULTS">In the MCF7 luminal subtype with positive ER, H3k4ac was significantly increased on BRCA1 with SAHA. On the contrary, in the MDA-MB 231 breast cancer cell line, representative of mesenchymal-like subtype with negative estrogen receptor, HDACis had no effect. Also, DZNEP decreased significantly H3K27me3 on BRCA1 in MDA-MB 231. Besides, on SRC3, a significant increase for H3K4ac was obtained in MCF7 treated with SAHA. And DZNEP had no effect in MCF7. Also, in MDA-MB 231 treated with DZNEP, H3K27me3 significantly decreased on SRC3 while H3K4ac was significantly increased in MDA-MB-231 treated with SAHA or NaBu for P300.</abstracttext></p>
<h4>CONCLUSION:</h4>
<p><abstracttext label="CONCLUSION" nlmcategory="CONCLUSIONS">Luminal and mesenchymal-like breast cancer subtype cell lines seemed to act differently to HDACis (SAHA and NaBu) or HMTi (DZNEP) treatments.</abstracttext></p>',
	'date' => '2016-07-01',
	'pmid' => 'http://www.ncbi.nlm.nih.gov/pubmed/27365379',
	'doi' => '',
	'modified' => '2016-07-12 12:50:21',
	'created' => '2016-07-12 12:46:04',
	'ProductsPublication' => array(
		'id' => '1434',
		'product_id' => '2517',
		'publication_id' => '2980'
	)
)
$externalLink = ' <a href="http://www.ncbi.nlm.nih.gov/pubmed/27365379" target="_blank"><i class="fa fa-external-link"></i></a>'
include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

Notice (8): Undefined variable: header [APP/View/Products/view.ctp, line 755]Code Context<!-- BEGIN: REQUEST_FORM MODAL -->
<div id="request_formModal" class="reveal-modal medium" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog">
    <?= $this->element('Forms/simple_form', array('solution_of_interest' => $solution_of_interest, 'header' => $header, 'message' => $message, 'campaign_id' => $campaign_id)) ?>
$viewFile = '/home/website-server/www/app/View/Products/view.ctp'
$dataForView = array(
	'language' => 'en',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'product' => array(
		'Product' => array(
			'id' => '2517',
			'antibody_id' => null,
			'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
			'label1' => '',
			'info1' => '',
			'label2' => '',
			'info2' => '',
			'label3' => '',
			'info3' => '',
			'format' => '50 µl',
			'catalog_number' => 'C17011004-50',
			'old_catalog_number' => 'pp-1004-050',
			'sf_code' => 'C17011004-D001-000014',
			'type' => 'FRE',
			'search_order' => '04-undefined',
			'price_EUR' => '60',
			'price_USD' => '35',
			'price_GBP' => '60',
			'price_JPY' => '9400',
			'price_CNY' => '',
			'price_AUD' => '88',
			'country' => 'ALL',
			'except_countries' => 'None',
			'quote' => false,
			'in_stock' => false,
			'featured' => true,
			'no_promo' => false,
			'online' => true,
			'master' => true,
			'last_datasheet_update' => '0000-00-00',
			'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
			'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'meta_keywords' => '',
			'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'modified' => '2016-10-21 08:17:25',
			'created' => '2015-06-29 14:08:20',
			'locale' => 'eng'
		),
		'Antibody' => array(
			'host' => '*****',
			'id' => null,
			'name' => null,
			'description' => null,
			'clonality' => null,
			'isotype' => null,
			'lot' => null,
			'concentration' => null,
			'reactivity' => null,
			'type' => null,
			'purity' => null,
			'classification' => null,
			'application_table' => null,
			'storage_conditions' => null,
			'storage_buffer' => null,
			'precautions' => null,
			'uniprot_acc' => null,
			'slug' => null,
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => null,
			'created' => null,
			'select_label' => null
		),
		'Slave' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Group' => array(
			'Group' => array(
				[maximum depth reached]
			),
			'Master' => array(
				[maximum depth reached]
			),
			'Product' => array(
				[maximum depth reached]
			)
		),
		'Related' => array(),
		'Application' => array(),
		'Category' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Document' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Feature' => array(),
		'Image' => array(),
		'Promotion' => array(),
		'Protocol' => array(),
		'Publication' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Testimonial' => array(),
		'Area' => array(),
		'SafetySheet' => array(
			(int) 0 => array(
				[maximum depth reached]
			),
			(int) 1 => array(
				[maximum depth reached]
			),
			(int) 2 => array(
				[maximum depth reached]
			),
			(int) 3 => array(
				[maximum depth reached]
			),
			(int) 4 => array(
				[maximum depth reached]
			),
			(int) 5 => array(
				[maximum depth reached]
			),
			(int) 6 => array(
				[maximum depth reached]
			),
			(int) 7 => array(
				[maximum depth reached]
			)
		)
	),
	'meta_canonical' => 'https://www.diagenode.com/en/p/human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul'
)
$language = 'en'
$meta_keywords = ''
$meta_description = 'Human  ChIP-seq grade c-fos promoter primer pair'
$meta_title = 'Human  ChIP-seq grade c-fos promoter primer pair'
$product = array(
	'Product' => array(
		'id' => '2517',
		'antibody_id' => null,
		'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
		'label1' => '',
		'info1' => '',
		'label2' => '',
		'info2' => '',
		'label3' => '',
		'info3' => '',
		'format' => '50 µl',
		'catalog_number' => 'C17011004-50',
		'old_catalog_number' => 'pp-1004-050',
		'sf_code' => 'C17011004-D001-000014',
		'type' => 'FRE',
		'search_order' => '04-undefined',
		'price_EUR' => '60',
		'price_USD' => '35',
		'price_GBP' => '60',
		'price_JPY' => '9400',
		'price_CNY' => '',
		'price_AUD' => '88',
		'country' => 'ALL',
		'except_countries' => 'None',
		'quote' => false,
		'in_stock' => false,
		'featured' => true,
		'no_promo' => false,
		'online' => true,
		'master' => true,
		'last_datasheet_update' => '0000-00-00',
		'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
		'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'meta_keywords' => '',
		'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'modified' => '2016-10-21 08:17:25',
		'created' => '2015-06-29 14:08:20',
		'locale' => 'eng'
	),
	'Antibody' => array(
		'host' => '*****',
		'id' => null,
		'name' => null,
		'description' => null,
		'clonality' => null,
		'isotype' => null,
		'lot' => null,
		'concentration' => null,
		'reactivity' => null,
		'type' => null,
		'purity' => null,
		'classification' => null,
		'application_table' => null,
		'storage_conditions' => null,
		'storage_buffer' => null,
		'precautions' => null,
		'uniprot_acc' => null,
		'slug' => null,
		'meta_keywords' => null,
		'meta_description' => null,
		'modified' => null,
		'created' => null,
		'select_label' => null
	),
	'Slave' => array(
		(int) 0 => array(
			'id' => '118',
			'name' => 'C17011004',
			'product_id' => '2517',
			'modified' => '2016-02-19 21:27:26',
			'created' => '2016-02-19 21:27:26'
		)
	),
	'Group' => array(
		'Group' => array(
			'id' => '118',
			'name' => 'C17011004',
			'product_id' => '2517',
			'modified' => '2016-02-19 21:27:26',
			'created' => '2016-02-19 21:27:26'
		),
		'Master' => array(
			'id' => '2517',
			'antibody_id' => null,
			'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
			'label1' => '',
			'info1' => '',
			'label2' => '',
			'info2' => '',
			'label3' => '',
			'info3' => '',
			'format' => '50 µl',
			'catalog_number' => 'C17011004-50',
			'old_catalog_number' => 'pp-1004-050',
			'sf_code' => 'C17011004-D001-000014',
			'type' => 'FRE',
			'search_order' => '04-undefined',
			'price_EUR' => '60',
			'price_USD' => '35',
			'price_GBP' => '60',
			'price_JPY' => '9400',
			'price_CNY' => '',
			'price_AUD' => '88',
			'country' => 'ALL',
			'except_countries' => 'None',
			'quote' => false,
			'in_stock' => false,
			'featured' => true,
			'no_promo' => false,
			'online' => true,
			'master' => true,
			'last_datasheet_update' => '0000-00-00',
			'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
			'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'meta_keywords' => '',
			'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'modified' => '2016-10-21 08:17:25',
			'created' => '2015-06-29 14:08:20'
		),
		'Product' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		)
	),
	'Related' => array(),
	'Application' => array(),
	'Category' => array(
		(int) 0 => array(
			'id' => '69',
			'position' => '1',
			'parent_id' => '35',
			'name' => 'Human',
			'description' => '<p>Primer pairs - Human</p>',
			'no_promo' => false,
			'in_menu' => false,
			'online' => true,
			'tabular' => true,
			'hide' => false,
			'all_format' => false,
			'is_antibody' => false,
			'slug' => 'primer-pairs-human',
			'cookies_tag_id' => null,
			'meta_keywords' => 'Primer pairs, human, ChIP-seq grade',
			'meta_description' => 'Diagenode offers Primer pairs for Human ChIP-seq grade',
			'meta_title' => 'Primer pairs - Human | Diagenode',
			'modified' => '2016-10-21 08:00:50',
			'created' => '2015-07-23 15:38:42',
			'ProductsCategory' => array(
				[maximum depth reached]
			),
			'CookiesTag' => array([maximum depth reached])
		)
	),
	'Document' => array(
		(int) 0 => array(
			'id' => '254',
			'name' => 'Datasheet Human cfos promoter pp1004',
			'description' => 'Datasheet description',
			'image_id' => null,
			'type' => 'Datasheet',
			'url' => 'files/products/reagents/primer_pairs/Datasheet_Human_cfos_promoter_pp1004.pdf',
			'slug' => 'datasheet-human-cfos-promoter-pp1004',
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => '2015-07-07 11:47:43',
			'created' => '2015-07-07 11:47:43',
			'ProductsDocument' => array(
				[maximum depth reached]
			)
		)
	),
	'Feature' => array(),
	'Image' => array(),
	'Promotion' => array(),
	'Protocol' => array(),
	'Publication' => array(
		(int) 0 => array(
			'id' => '2980',
			'name' => 'Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells',
			'authors' => 'Dagdemir A et al.',
			'description' => '<h4>BACKGROUND/AIM:</h4>
<p><abstracttext label="BACKGROUND/AIM" nlmcategory="OBJECTIVE">Numerous studies have shown that breast cancer and epigenetic mechanisms have a very powerful interactive relation. The MCF7 cell line, representative of luminal subtype and the MDA-MB 231 cell line representative of mesenchymal-like subtype were treated respectively with a Histone Methyl Transferase Inhibitors (HMTi), 3-Deazaneplanocin hydrochloride (DZNep), two histone deacetylase inhibitors (HDACi), sodium butyrate (NaBu), and suberoylanilide hydroxamic acid (SAHA) for 48 h.</abstracttext></p>
<h4>MATERIALS AND METHODS:</h4>
<p><abstracttext label="MATERIALS AND METHODS" nlmcategory="METHODS">Chromatin immunoprecipitation (ChIP) was used to observe HDACis (SAHA and NaBu) and HMTi (DZNep) impact on histones and more specifically on H3K27me3, H3K9ac and H3K4ac marks with Q-PCR analysis of BRCA1, SRC3 and P300 genes. Furthermore, the HDACi and HMTi effects on mRNA and protein expression of BRCA1, SRC3 and P300 genes were checked. In addition, statistical analyses were used.</abstracttext></p>
<h4>RESULTS:</h4>
<p><abstracttext label="RESULTS" nlmcategory="RESULTS">In the MCF7 luminal subtype with positive ER, H3k4ac was significantly increased on BRCA1 with SAHA. On the contrary, in the MDA-MB 231 breast cancer cell line, representative of mesenchymal-like subtype with negative estrogen receptor, HDACis had no effect. Also, DZNEP decreased significantly H3K27me3 on BRCA1 in MDA-MB 231. Besides, on SRC3, a significant increase for H3K4ac was obtained in MCF7 treated with SAHA. And DZNEP had no effect in MCF7. Also, in MDA-MB 231 treated with DZNEP, H3K27me3 significantly decreased on SRC3 while H3K4ac was significantly increased in MDA-MB-231 treated with SAHA or NaBu for P300.</abstracttext></p>
<h4>CONCLUSION:</h4>
<p><abstracttext label="CONCLUSION" nlmcategory="CONCLUSIONS">Luminal and mesenchymal-like breast cancer subtype cell lines seemed to act differently to HDACis (SAHA and NaBu) or HMTi (DZNEP) treatments.</abstracttext></p>',
			'date' => '2016-07-01',
			'pmid' => 'http://www.ncbi.nlm.nih.gov/pubmed/27365379',
			'doi' => '',
			'modified' => '2016-07-12 12:50:21',
			'created' => '2016-07-12 12:46:04',
			'ProductsPublication' => array(
				[maximum depth reached]
			)
		)
	),
	'Testimonial' => array(),
	'Area' => array(),
	'SafetySheet' => array(
		(int) 0 => array(
			'id' => '270',
			'name' => 'c-fos Promoter Primer Pair SDS GB en',
			'language' => 'en',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-GB-en-GHS_1_0.pdf',
			'countries' => 'GB',
			'modified' => '2020-06-09 10:33:07',
			'created' => '2020-06-09 10:33:07',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 1 => array(
			'id' => '272',
			'name' => 'c-fos Promoter Primer Pair SDS US en',
			'language' => 'en',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-US-en-GHS_1_0.pdf',
			'countries' => 'US',
			'modified' => '2020-06-09 10:34:22',
			'created' => '2020-06-09 10:34:22',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 2 => array(
			'id' => '267',
			'name' => 'c-fos Promoter Primer Pair SDS DE de',
			'language' => 'de',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-DE-de-GHS_1_0.pdf',
			'countries' => 'DE',
			'modified' => '2020-06-09 10:27:14',
			'created' => '2020-06-09 10:27:14',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 3 => array(
			'id' => '271',
			'name' => 'c-fos Promoter Primer Pair SDS JP ja',
			'language' => 'ja',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-JP-ja-GHS_2_0.pdf',
			'countries' => 'JP',
			'modified' => '2020-06-09 10:33:45',
			'created' => '2020-06-09 10:33:45',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 4 => array(
			'id' => '266',
			'name' => 'c-fos Promoter Primer Pair SDS BE nl',
			'language' => 'nl',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-BE-nl-GHS_1_0.pdf',
			'countries' => 'BE',
			'modified' => '2020-06-09 10:25:59',
			'created' => '2020-06-09 10:25:59',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 5 => array(
			'id' => '265',
			'name' => 'c-fos Promoter Primer Pair SDS BE fr',
			'language' => 'fr',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-BE-fr-GHS_1_0.pdf',
			'countries' => 'BE',
			'modified' => '2020-06-09 10:24:34',
			'created' => '2020-06-09 10:24:34',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 6 => array(
			'id' => '269',
			'name' => 'c-fos Promoter Primer Pair SDS FR fr',
			'language' => 'fr',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-FR-fr-GHS_1_0.pdf',
			'countries' => 'FR',
			'modified' => '2020-06-09 10:29:06',
			'created' => '2020-06-09 10:29:06',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 7 => array(
			'id' => '268',
			'name' => 'c-fos Promoter Primer Pair SDS ES es',
			'language' => 'es',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-ES-es-GHS_1_0.pdf',
			'countries' => 'ES',
			'modified' => '2020-06-09 10:28:17',
			'created' => '2020-06-09 10:28:17',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		)
	)
)
$meta_canonical = 'https://www.diagenode.com/en/p/human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul'
$country = 'US'
$countries_allowed = array(
	(int) 0 => 'CA',
	(int) 1 => 'US',
	(int) 2 => 'IE',
	(int) 3 => 'GB',
	(int) 4 => 'DK',
	(int) 5 => 'NO',
	(int) 6 => 'SE',
	(int) 7 => 'FI',
	(int) 8 => 'NL',
	(int) 9 => 'BE',
	(int) 10 => 'LU',
	(int) 11 => 'FR',
	(int) 12 => 'DE',
	(int) 13 => 'CH',
	(int) 14 => 'AT',
	(int) 15 => 'ES',
	(int) 16 => 'IT',
	(int) 17 => 'PT'
)
$outsource = false
$other_formats = array(
	(int) 0 => array(
		'id' => '2518',
		'antibody_id' => null,
		'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
		'label1' => '',
		'info1' => '',
		'label2' => '',
		'info2' => '',
		'label3' => '',
		'info3' => '',
		'format' => '500 µl',
		'catalog_number' => 'C17011004-500',
		'old_catalog_number' => 'pp-1004-500',
		'sf_code' => 'C17011004-D001-000015',
		'type' => 'FRE',
		'search_order' => '04-undefined',
		'price_EUR' => '115',
		'price_USD' => '100',
		'price_GBP' => '105',
		'price_JPY' => '18015',
		'price_CNY' => '',
		'price_AUD' => '250',
		'country' => 'ALL',
		'except_countries' => 'None',
		'quote' => false,
		'in_stock' => false,
		'featured' => true,
		'no_promo' => false,
		'online' => true,
		'master' => false,
		'last_datasheet_update' => '0000-00-00',
		'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
		'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'meta_keywords' => '',
		'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'modified' => '2016-02-19 21:27:54',
		'created' => '2015-06-29 14:08:20',
		'ProductsGroup' => array(
			'id' => '129',
			'product_id' => '2518',
			'group_id' => '118'
		)
	)
)
$pro = array(
	'id' => '2518',
	'antibody_id' => null,
	'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
	'label1' => '',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '500 µl',
	'catalog_number' => 'C17011004-500',
	'old_catalog_number' => 'pp-1004-500',
	'sf_code' => 'C17011004-D001-000015',
	'type' => 'FRE',
	'search_order' => '04-undefined',
	'price_EUR' => '115',
	'price_USD' => '100',
	'price_GBP' => '105',
	'price_JPY' => '18015',
	'price_CNY' => '',
	'price_AUD' => '250',
	'country' => 'ALL',
	'except_countries' => 'None',
	'quote' => false,
	'in_stock' => false,
	'featured' => true,
	'no_promo' => false,
	'online' => true,
	'master' => false,
	'last_datasheet_update' => '0000-00-00',
	'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'modified' => '2016-02-19 21:27:54',
	'created' => '2015-06-29 14:08:20',
	'ProductsGroup' => array(
		'id' => '129',
		'product_id' => '2518',
		'group_id' => '118'
	)
)
$edit = ''
$testimonials = ''
$featured_testimonials = ''
$related_products = ''
$rrbs_service = array(
	(int) 0 => (int) 1894,
	(int) 1 => (int) 1895
)
$chipseq_service = array(
	(int) 0 => (int) 2683,
	(int) 1 => (int) 1835,
	(int) 2 => (int) 1836,
	(int) 3 => (int) 2684,
	(int) 4 => (int) 1838,
	(int) 5 => (int) 1839,
	(int) 6 => (int) 1856
)
$labelize = object(Closure) {
	
}
$old_catalog_number = ' <span style="color:#CCC">(pp-1004-500)</span>'
$country_code = 'US'
$other_format = array(
	'id' => '2518',
	'antibody_id' => null,
	'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
	'label1' => '',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '500 µl',
	'catalog_number' => 'C17011004-500',
	'old_catalog_number' => 'pp-1004-500',
	'sf_code' => 'C17011004-D001-000015',
	'type' => 'FRE',
	'search_order' => '04-undefined',
	'price_EUR' => '115',
	'price_USD' => '100',
	'price_GBP' => '105',
	'price_JPY' => '18015',
	'price_CNY' => '',
	'price_AUD' => '250',
	'country' => 'ALL',
	'except_countries' => 'None',
	'quote' => false,
	'in_stock' => false,
	'featured' => true,
	'no_promo' => false,
	'online' => true,
	'master' => false,
	'last_datasheet_update' => '0000-00-00',
	'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'modified' => '2016-02-19 21:27:54',
	'created' => '2015-06-29 14:08:20',
	'ProductsGroup' => array(
		'id' => '129',
		'product_id' => '2518',
		'group_id' => '118'
	)
)
$label = '<img src="/img/banners/banner-customizer-back.png" alt=""/>'
$document = array(
	'id' => '254',
	'name' => 'Datasheet Human cfos promoter pp1004',
	'description' => 'Datasheet description',
	'image_id' => null,
	'type' => 'Datasheet',
	'url' => 'files/products/reagents/primer_pairs/Datasheet_Human_cfos_promoter_pp1004.pdf',
	'slug' => 'datasheet-human-cfos-promoter-pp1004',
	'meta_keywords' => null,
	'meta_description' => null,
	'modified' => '2015-07-07 11:47:43',
	'created' => '2015-07-07 11:47:43',
	'ProductsDocument' => array(
		'id' => '586',
		'product_id' => '2517',
		'document_id' => '254'
	)
)
$sds = array(
	'id' => '268',
	'name' => 'c-fos Promoter Primer Pair SDS ES es',
	'language' => 'es',
	'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-ES-es-GHS_1_0.pdf',
	'countries' => 'ES',
	'modified' => '2020-06-09 10:28:17',
	'created' => '2020-06-09 10:28:17',
	'ProductsSafetySheet' => array(
		'id' => '502',
		'product_id' => '2517',
		'safety_sheet_id' => '268'
	)
)
$publication = array(
	'id' => '2980',
	'name' => 'Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells',
	'authors' => 'Dagdemir A et al.',
	'description' => '<h4>BACKGROUND/AIM:</h4>
<p><abstracttext label="BACKGROUND/AIM" nlmcategory="OBJECTIVE">Numerous studies have shown that breast cancer and epigenetic mechanisms have a very powerful interactive relation. The MCF7 cell line, representative of luminal subtype and the MDA-MB 231 cell line representative of mesenchymal-like subtype were treated respectively with a Histone Methyl Transferase Inhibitors (HMTi), 3-Deazaneplanocin hydrochloride (DZNep), two histone deacetylase inhibitors (HDACi), sodium butyrate (NaBu), and suberoylanilide hydroxamic acid (SAHA) for 48 h.</abstracttext></p>
<h4>MATERIALS AND METHODS:</h4>
<p><abstracttext label="MATERIALS AND METHODS" nlmcategory="METHODS">Chromatin immunoprecipitation (ChIP) was used to observe HDACis (SAHA and NaBu) and HMTi (DZNep) impact on histones and more specifically on H3K27me3, H3K9ac and H3K4ac marks with Q-PCR analysis of BRCA1, SRC3 and P300 genes. Furthermore, the HDACi and HMTi effects on mRNA and protein expression of BRCA1, SRC3 and P300 genes were checked. In addition, statistical analyses were used.</abstracttext></p>
<h4>RESULTS:</h4>
<p><abstracttext label="RESULTS" nlmcategory="RESULTS">In the MCF7 luminal subtype with positive ER, H3k4ac was significantly increased on BRCA1 with SAHA. On the contrary, in the MDA-MB 231 breast cancer cell line, representative of mesenchymal-like subtype with negative estrogen receptor, HDACis had no effect. Also, DZNEP decreased significantly H3K27me3 on BRCA1 in MDA-MB 231. Besides, on SRC3, a significant increase for H3K4ac was obtained in MCF7 treated with SAHA. And DZNEP had no effect in MCF7. Also, in MDA-MB 231 treated with DZNEP, H3K27me3 significantly decreased on SRC3 while H3K4ac was significantly increased in MDA-MB-231 treated with SAHA or NaBu for P300.</abstracttext></p>
<h4>CONCLUSION:</h4>
<p><abstracttext label="CONCLUSION" nlmcategory="CONCLUSIONS">Luminal and mesenchymal-like breast cancer subtype cell lines seemed to act differently to HDACis (SAHA and NaBu) or HMTi (DZNEP) treatments.</abstracttext></p>',
	'date' => '2016-07-01',
	'pmid' => 'http://www.ncbi.nlm.nih.gov/pubmed/27365379',
	'doi' => '',
	'modified' => '2016-07-12 12:50:21',
	'created' => '2016-07-12 12:46:04',
	'ProductsPublication' => array(
		'id' => '1434',
		'product_id' => '2517',
		'publication_id' => '2980'
	)
)
$externalLink = ' <a href="http://www.ncbi.nlm.nih.gov/pubmed/27365379" target="_blank"><i class="fa fa-external-link"></i></a>'
include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

Notice (8): Undefined variable: message [APP/View/Products/view.ctp, line 755]Code Context<!-- BEGIN: REQUEST_FORM MODAL -->
<div id="request_formModal" class="reveal-modal medium" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog">
    <?= $this->element('Forms/simple_form', array('solution_of_interest' => $solution_of_interest, 'header' => $header, 'message' => $message, 'campaign_id' => $campaign_id)) ?>
$viewFile = '/home/website-server/www/app/View/Products/view.ctp'
$dataForView = array(
	'language' => 'en',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'product' => array(
		'Product' => array(
			'id' => '2517',
			'antibody_id' => null,
			'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
			'label1' => '',
			'info1' => '',
			'label2' => '',
			'info2' => '',
			'label3' => '',
			'info3' => '',
			'format' => '50 µl',
			'catalog_number' => 'C17011004-50',
			'old_catalog_number' => 'pp-1004-050',
			'sf_code' => 'C17011004-D001-000014',
			'type' => 'FRE',
			'search_order' => '04-undefined',
			'price_EUR' => '60',
			'price_USD' => '35',
			'price_GBP' => '60',
			'price_JPY' => '9400',
			'price_CNY' => '',
			'price_AUD' => '88',
			'country' => 'ALL',
			'except_countries' => 'None',
			'quote' => false,
			'in_stock' => false,
			'featured' => true,
			'no_promo' => false,
			'online' => true,
			'master' => true,
			'last_datasheet_update' => '0000-00-00',
			'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
			'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'meta_keywords' => '',
			'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'modified' => '2016-10-21 08:17:25',
			'created' => '2015-06-29 14:08:20',
			'locale' => 'eng'
		),
		'Antibody' => array(
			'host' => '*****',
			'id' => null,
			'name' => null,
			'description' => null,
			'clonality' => null,
			'isotype' => null,
			'lot' => null,
			'concentration' => null,
			'reactivity' => null,
			'type' => null,
			'purity' => null,
			'classification' => null,
			'application_table' => null,
			'storage_conditions' => null,
			'storage_buffer' => null,
			'precautions' => null,
			'uniprot_acc' => null,
			'slug' => null,
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => null,
			'created' => null,
			'select_label' => null
		),
		'Slave' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Group' => array(
			'Group' => array(
				[maximum depth reached]
			),
			'Master' => array(
				[maximum depth reached]
			),
			'Product' => array(
				[maximum depth reached]
			)
		),
		'Related' => array(),
		'Application' => array(),
		'Category' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Document' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Feature' => array(),
		'Image' => array(),
		'Promotion' => array(),
		'Protocol' => array(),
		'Publication' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Testimonial' => array(),
		'Area' => array(),
		'SafetySheet' => array(
			(int) 0 => array(
				[maximum depth reached]
			),
			(int) 1 => array(
				[maximum depth reached]
			),
			(int) 2 => array(
				[maximum depth reached]
			),
			(int) 3 => array(
				[maximum depth reached]
			),
			(int) 4 => array(
				[maximum depth reached]
			),
			(int) 5 => array(
				[maximum depth reached]
			),
			(int) 6 => array(
				[maximum depth reached]
			),
			(int) 7 => array(
				[maximum depth reached]
			)
		)
	),
	'meta_canonical' => 'https://www.diagenode.com/en/p/human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul'
)
$language = 'en'
$meta_keywords = ''
$meta_description = 'Human  ChIP-seq grade c-fos promoter primer pair'
$meta_title = 'Human  ChIP-seq grade c-fos promoter primer pair'
$product = array(
	'Product' => array(
		'id' => '2517',
		'antibody_id' => null,
		'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
		'label1' => '',
		'info1' => '',
		'label2' => '',
		'info2' => '',
		'label3' => '',
		'info3' => '',
		'format' => '50 µl',
		'catalog_number' => 'C17011004-50',
		'old_catalog_number' => 'pp-1004-050',
		'sf_code' => 'C17011004-D001-000014',
		'type' => 'FRE',
		'search_order' => '04-undefined',
		'price_EUR' => '60',
		'price_USD' => '35',
		'price_GBP' => '60',
		'price_JPY' => '9400',
		'price_CNY' => '',
		'price_AUD' => '88',
		'country' => 'ALL',
		'except_countries' => 'None',
		'quote' => false,
		'in_stock' => false,
		'featured' => true,
		'no_promo' => false,
		'online' => true,
		'master' => true,
		'last_datasheet_update' => '0000-00-00',
		'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
		'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'meta_keywords' => '',
		'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'modified' => '2016-10-21 08:17:25',
		'created' => '2015-06-29 14:08:20',
		'locale' => 'eng'
	),
	'Antibody' => array(
		'host' => '*****',
		'id' => null,
		'name' => null,
		'description' => null,
		'clonality' => null,
		'isotype' => null,
		'lot' => null,
		'concentration' => null,
		'reactivity' => null,
		'type' => null,
		'purity' => null,
		'classification' => null,
		'application_table' => null,
		'storage_conditions' => null,
		'storage_buffer' => null,
		'precautions' => null,
		'uniprot_acc' => null,
		'slug' => null,
		'meta_keywords' => null,
		'meta_description' => null,
		'modified' => null,
		'created' => null,
		'select_label' => null
	),
	'Slave' => array(
		(int) 0 => array(
			'id' => '118',
			'name' => 'C17011004',
			'product_id' => '2517',
			'modified' => '2016-02-19 21:27:26',
			'created' => '2016-02-19 21:27:26'
		)
	),
	'Group' => array(
		'Group' => array(
			'id' => '118',
			'name' => 'C17011004',
			'product_id' => '2517',
			'modified' => '2016-02-19 21:27:26',
			'created' => '2016-02-19 21:27:26'
		),
		'Master' => array(
			'id' => '2517',
			'antibody_id' => null,
			'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
			'label1' => '',
			'info1' => '',
			'label2' => '',
			'info2' => '',
			'label3' => '',
			'info3' => '',
			'format' => '50 µl',
			'catalog_number' => 'C17011004-50',
			'old_catalog_number' => 'pp-1004-050',
			'sf_code' => 'C17011004-D001-000014',
			'type' => 'FRE',
			'search_order' => '04-undefined',
			'price_EUR' => '60',
			'price_USD' => '35',
			'price_GBP' => '60',
			'price_JPY' => '9400',
			'price_CNY' => '',
			'price_AUD' => '88',
			'country' => 'ALL',
			'except_countries' => 'None',
			'quote' => false,
			'in_stock' => false,
			'featured' => true,
			'no_promo' => false,
			'online' => true,
			'master' => true,
			'last_datasheet_update' => '0000-00-00',
			'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
			'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'meta_keywords' => '',
			'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'modified' => '2016-10-21 08:17:25',
			'created' => '2015-06-29 14:08:20'
		),
		'Product' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		)
	),
	'Related' => array(),
	'Application' => array(),
	'Category' => array(
		(int) 0 => array(
			'id' => '69',
			'position' => '1',
			'parent_id' => '35',
			'name' => 'Human',
			'description' => '<p>Primer pairs - Human</p>',
			'no_promo' => false,
			'in_menu' => false,
			'online' => true,
			'tabular' => true,
			'hide' => false,
			'all_format' => false,
			'is_antibody' => false,
			'slug' => 'primer-pairs-human',
			'cookies_tag_id' => null,
			'meta_keywords' => 'Primer pairs, human, ChIP-seq grade',
			'meta_description' => 'Diagenode offers Primer pairs for Human ChIP-seq grade',
			'meta_title' => 'Primer pairs - Human | Diagenode',
			'modified' => '2016-10-21 08:00:50',
			'created' => '2015-07-23 15:38:42',
			'ProductsCategory' => array(
				[maximum depth reached]
			),
			'CookiesTag' => array([maximum depth reached])
		)
	),
	'Document' => array(
		(int) 0 => array(
			'id' => '254',
			'name' => 'Datasheet Human cfos promoter pp1004',
			'description' => 'Datasheet description',
			'image_id' => null,
			'type' => 'Datasheet',
			'url' => 'files/products/reagents/primer_pairs/Datasheet_Human_cfos_promoter_pp1004.pdf',
			'slug' => 'datasheet-human-cfos-promoter-pp1004',
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => '2015-07-07 11:47:43',
			'created' => '2015-07-07 11:47:43',
			'ProductsDocument' => array(
				[maximum depth reached]
			)
		)
	),
	'Feature' => array(),
	'Image' => array(),
	'Promotion' => array(),
	'Protocol' => array(),
	'Publication' => array(
		(int) 0 => array(
			'id' => '2980',
			'name' => 'Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells',
			'authors' => 'Dagdemir A et al.',
			'description' => '<h4>BACKGROUND/AIM:</h4>
<p><abstracttext label="BACKGROUND/AIM" nlmcategory="OBJECTIVE">Numerous studies have shown that breast cancer and epigenetic mechanisms have a very powerful interactive relation. The MCF7 cell line, representative of luminal subtype and the MDA-MB 231 cell line representative of mesenchymal-like subtype were treated respectively with a Histone Methyl Transferase Inhibitors (HMTi), 3-Deazaneplanocin hydrochloride (DZNep), two histone deacetylase inhibitors (HDACi), sodium butyrate (NaBu), and suberoylanilide hydroxamic acid (SAHA) for 48 h.</abstracttext></p>
<h4>MATERIALS AND METHODS:</h4>
<p><abstracttext label="MATERIALS AND METHODS" nlmcategory="METHODS">Chromatin immunoprecipitation (ChIP) was used to observe HDACis (SAHA and NaBu) and HMTi (DZNep) impact on histones and more specifically on H3K27me3, H3K9ac and H3K4ac marks with Q-PCR analysis of BRCA1, SRC3 and P300 genes. Furthermore, the HDACi and HMTi effects on mRNA and protein expression of BRCA1, SRC3 and P300 genes were checked. In addition, statistical analyses were used.</abstracttext></p>
<h4>RESULTS:</h4>
<p><abstracttext label="RESULTS" nlmcategory="RESULTS">In the MCF7 luminal subtype with positive ER, H3k4ac was significantly increased on BRCA1 with SAHA. On the contrary, in the MDA-MB 231 breast cancer cell line, representative of mesenchymal-like subtype with negative estrogen receptor, HDACis had no effect. Also, DZNEP decreased significantly H3K27me3 on BRCA1 in MDA-MB 231. Besides, on SRC3, a significant increase for H3K4ac was obtained in MCF7 treated with SAHA. And DZNEP had no effect in MCF7. Also, in MDA-MB 231 treated with DZNEP, H3K27me3 significantly decreased on SRC3 while H3K4ac was significantly increased in MDA-MB-231 treated with SAHA or NaBu for P300.</abstracttext></p>
<h4>CONCLUSION:</h4>
<p><abstracttext label="CONCLUSION" nlmcategory="CONCLUSIONS">Luminal and mesenchymal-like breast cancer subtype cell lines seemed to act differently to HDACis (SAHA and NaBu) or HMTi (DZNEP) treatments.</abstracttext></p>',
			'date' => '2016-07-01',
			'pmid' => 'http://www.ncbi.nlm.nih.gov/pubmed/27365379',
			'doi' => '',
			'modified' => '2016-07-12 12:50:21',
			'created' => '2016-07-12 12:46:04',
			'ProductsPublication' => array(
				[maximum depth reached]
			)
		)
	),
	'Testimonial' => array(),
	'Area' => array(),
	'SafetySheet' => array(
		(int) 0 => array(
			'id' => '270',
			'name' => 'c-fos Promoter Primer Pair SDS GB en',
			'language' => 'en',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-GB-en-GHS_1_0.pdf',
			'countries' => 'GB',
			'modified' => '2020-06-09 10:33:07',
			'created' => '2020-06-09 10:33:07',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 1 => array(
			'id' => '272',
			'name' => 'c-fos Promoter Primer Pair SDS US en',
			'language' => 'en',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-US-en-GHS_1_0.pdf',
			'countries' => 'US',
			'modified' => '2020-06-09 10:34:22',
			'created' => '2020-06-09 10:34:22',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 2 => array(
			'id' => '267',
			'name' => 'c-fos Promoter Primer Pair SDS DE de',
			'language' => 'de',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-DE-de-GHS_1_0.pdf',
			'countries' => 'DE',
			'modified' => '2020-06-09 10:27:14',
			'created' => '2020-06-09 10:27:14',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 3 => array(
			'id' => '271',
			'name' => 'c-fos Promoter Primer Pair SDS JP ja',
			'language' => 'ja',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-JP-ja-GHS_2_0.pdf',
			'countries' => 'JP',
			'modified' => '2020-06-09 10:33:45',
			'created' => '2020-06-09 10:33:45',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 4 => array(
			'id' => '266',
			'name' => 'c-fos Promoter Primer Pair SDS BE nl',
			'language' => 'nl',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-BE-nl-GHS_1_0.pdf',
			'countries' => 'BE',
			'modified' => '2020-06-09 10:25:59',
			'created' => '2020-06-09 10:25:59',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 5 => array(
			'id' => '265',
			'name' => 'c-fos Promoter Primer Pair SDS BE fr',
			'language' => 'fr',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-BE-fr-GHS_1_0.pdf',
			'countries' => 'BE',
			'modified' => '2020-06-09 10:24:34',
			'created' => '2020-06-09 10:24:34',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 6 => array(
			'id' => '269',
			'name' => 'c-fos Promoter Primer Pair SDS FR fr',
			'language' => 'fr',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-FR-fr-GHS_1_0.pdf',
			'countries' => 'FR',
			'modified' => '2020-06-09 10:29:06',
			'created' => '2020-06-09 10:29:06',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 7 => array(
			'id' => '268',
			'name' => 'c-fos Promoter Primer Pair SDS ES es',
			'language' => 'es',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-ES-es-GHS_1_0.pdf',
			'countries' => 'ES',
			'modified' => '2020-06-09 10:28:17',
			'created' => '2020-06-09 10:28:17',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		)
	)
)
$meta_canonical = 'https://www.diagenode.com/en/p/human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul'
$country = 'US'
$countries_allowed = array(
	(int) 0 => 'CA',
	(int) 1 => 'US',
	(int) 2 => 'IE',
	(int) 3 => 'GB',
	(int) 4 => 'DK',
	(int) 5 => 'NO',
	(int) 6 => 'SE',
	(int) 7 => 'FI',
	(int) 8 => 'NL',
	(int) 9 => 'BE',
	(int) 10 => 'LU',
	(int) 11 => 'FR',
	(int) 12 => 'DE',
	(int) 13 => 'CH',
	(int) 14 => 'AT',
	(int) 15 => 'ES',
	(int) 16 => 'IT',
	(int) 17 => 'PT'
)
$outsource = false
$other_formats = array(
	(int) 0 => array(
		'id' => '2518',
		'antibody_id' => null,
		'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
		'label1' => '',
		'info1' => '',
		'label2' => '',
		'info2' => '',
		'label3' => '',
		'info3' => '',
		'format' => '500 µl',
		'catalog_number' => 'C17011004-500',
		'old_catalog_number' => 'pp-1004-500',
		'sf_code' => 'C17011004-D001-000015',
		'type' => 'FRE',
		'search_order' => '04-undefined',
		'price_EUR' => '115',
		'price_USD' => '100',
		'price_GBP' => '105',
		'price_JPY' => '18015',
		'price_CNY' => '',
		'price_AUD' => '250',
		'country' => 'ALL',
		'except_countries' => 'None',
		'quote' => false,
		'in_stock' => false,
		'featured' => true,
		'no_promo' => false,
		'online' => true,
		'master' => false,
		'last_datasheet_update' => '0000-00-00',
		'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
		'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'meta_keywords' => '',
		'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'modified' => '2016-02-19 21:27:54',
		'created' => '2015-06-29 14:08:20',
		'ProductsGroup' => array(
			'id' => '129',
			'product_id' => '2518',
			'group_id' => '118'
		)
	)
)
$pro = array(
	'id' => '2518',
	'antibody_id' => null,
	'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
	'label1' => '',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '500 µl',
	'catalog_number' => 'C17011004-500',
	'old_catalog_number' => 'pp-1004-500',
	'sf_code' => 'C17011004-D001-000015',
	'type' => 'FRE',
	'search_order' => '04-undefined',
	'price_EUR' => '115',
	'price_USD' => '100',
	'price_GBP' => '105',
	'price_JPY' => '18015',
	'price_CNY' => '',
	'price_AUD' => '250',
	'country' => 'ALL',
	'except_countries' => 'None',
	'quote' => false,
	'in_stock' => false,
	'featured' => true,
	'no_promo' => false,
	'online' => true,
	'master' => false,
	'last_datasheet_update' => '0000-00-00',
	'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'modified' => '2016-02-19 21:27:54',
	'created' => '2015-06-29 14:08:20',
	'ProductsGroup' => array(
		'id' => '129',
		'product_id' => '2518',
		'group_id' => '118'
	)
)
$edit = ''
$testimonials = ''
$featured_testimonials = ''
$related_products = ''
$rrbs_service = array(
	(int) 0 => (int) 1894,
	(int) 1 => (int) 1895
)
$chipseq_service = array(
	(int) 0 => (int) 2683,
	(int) 1 => (int) 1835,
	(int) 2 => (int) 1836,
	(int) 3 => (int) 2684,
	(int) 4 => (int) 1838,
	(int) 5 => (int) 1839,
	(int) 6 => (int) 1856
)
$labelize = object(Closure) {
	
}
$old_catalog_number = ' <span style="color:#CCC">(pp-1004-500)</span>'
$country_code = 'US'
$other_format = array(
	'id' => '2518',
	'antibody_id' => null,
	'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
	'label1' => '',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '500 µl',
	'catalog_number' => 'C17011004-500',
	'old_catalog_number' => 'pp-1004-500',
	'sf_code' => 'C17011004-D001-000015',
	'type' => 'FRE',
	'search_order' => '04-undefined',
	'price_EUR' => '115',
	'price_USD' => '100',
	'price_GBP' => '105',
	'price_JPY' => '18015',
	'price_CNY' => '',
	'price_AUD' => '250',
	'country' => 'ALL',
	'except_countries' => 'None',
	'quote' => false,
	'in_stock' => false,
	'featured' => true,
	'no_promo' => false,
	'online' => true,
	'master' => false,
	'last_datasheet_update' => '0000-00-00',
	'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'modified' => '2016-02-19 21:27:54',
	'created' => '2015-06-29 14:08:20',
	'ProductsGroup' => array(
		'id' => '129',
		'product_id' => '2518',
		'group_id' => '118'
	)
)
$label = '<img src="/img/banners/banner-customizer-back.png" alt=""/>'
$document = array(
	'id' => '254',
	'name' => 'Datasheet Human cfos promoter pp1004',
	'description' => 'Datasheet description',
	'image_id' => null,
	'type' => 'Datasheet',
	'url' => 'files/products/reagents/primer_pairs/Datasheet_Human_cfos_promoter_pp1004.pdf',
	'slug' => 'datasheet-human-cfos-promoter-pp1004',
	'meta_keywords' => null,
	'meta_description' => null,
	'modified' => '2015-07-07 11:47:43',
	'created' => '2015-07-07 11:47:43',
	'ProductsDocument' => array(
		'id' => '586',
		'product_id' => '2517',
		'document_id' => '254'
	)
)
$sds = array(
	'id' => '268',
	'name' => 'c-fos Promoter Primer Pair SDS ES es',
	'language' => 'es',
	'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-ES-es-GHS_1_0.pdf',
	'countries' => 'ES',
	'modified' => '2020-06-09 10:28:17',
	'created' => '2020-06-09 10:28:17',
	'ProductsSafetySheet' => array(
		'id' => '502',
		'product_id' => '2517',
		'safety_sheet_id' => '268'
	)
)
$publication = array(
	'id' => '2980',
	'name' => 'Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells',
	'authors' => 'Dagdemir A et al.',
	'description' => '<h4>BACKGROUND/AIM:</h4>
<p><abstracttext label="BACKGROUND/AIM" nlmcategory="OBJECTIVE">Numerous studies have shown that breast cancer and epigenetic mechanisms have a very powerful interactive relation. The MCF7 cell line, representative of luminal subtype and the MDA-MB 231 cell line representative of mesenchymal-like subtype were treated respectively with a Histone Methyl Transferase Inhibitors (HMTi), 3-Deazaneplanocin hydrochloride (DZNep), two histone deacetylase inhibitors (HDACi), sodium butyrate (NaBu), and suberoylanilide hydroxamic acid (SAHA) for 48 h.</abstracttext></p>
<h4>MATERIALS AND METHODS:</h4>
<p><abstracttext label="MATERIALS AND METHODS" nlmcategory="METHODS">Chromatin immunoprecipitation (ChIP) was used to observe HDACis (SAHA and NaBu) and HMTi (DZNep) impact on histones and more specifically on H3K27me3, H3K9ac and H3K4ac marks with Q-PCR analysis of BRCA1, SRC3 and P300 genes. Furthermore, the HDACi and HMTi effects on mRNA and protein expression of BRCA1, SRC3 and P300 genes were checked. In addition, statistical analyses were used.</abstracttext></p>
<h4>RESULTS:</h4>
<p><abstracttext label="RESULTS" nlmcategory="RESULTS">In the MCF7 luminal subtype with positive ER, H3k4ac was significantly increased on BRCA1 with SAHA. On the contrary, in the MDA-MB 231 breast cancer cell line, representative of mesenchymal-like subtype with negative estrogen receptor, HDACis had no effect. Also, DZNEP decreased significantly H3K27me3 on BRCA1 in MDA-MB 231. Besides, on SRC3, a significant increase for H3K4ac was obtained in MCF7 treated with SAHA. And DZNEP had no effect in MCF7. Also, in MDA-MB 231 treated with DZNEP, H3K27me3 significantly decreased on SRC3 while H3K4ac was significantly increased in MDA-MB-231 treated with SAHA or NaBu for P300.</abstracttext></p>
<h4>CONCLUSION:</h4>
<p><abstracttext label="CONCLUSION" nlmcategory="CONCLUSIONS">Luminal and mesenchymal-like breast cancer subtype cell lines seemed to act differently to HDACis (SAHA and NaBu) or HMTi (DZNEP) treatments.</abstracttext></p>',
	'date' => '2016-07-01',
	'pmid' => 'http://www.ncbi.nlm.nih.gov/pubmed/27365379',
	'doi' => '',
	'modified' => '2016-07-12 12:50:21',
	'created' => '2016-07-12 12:46:04',
	'ProductsPublication' => array(
		'id' => '1434',
		'product_id' => '2517',
		'publication_id' => '2980'
	)
)
$externalLink = ' <a href="http://www.ncbi.nlm.nih.gov/pubmed/27365379" target="_blank"><i class="fa fa-external-link"></i></a>'
include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

Notice (8): Undefined variable: campaign_id [APP/View/Products/view.ctp, line 755]Code Context<!-- BEGIN: REQUEST_FORM MODAL -->
<div id="request_formModal" class="reveal-modal medium" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog">
    <?= $this->element('Forms/simple_form', array('solution_of_interest' => $solution_of_interest, 'header' => $header, 'message' => $message, 'campaign_id' => $campaign_id)) ?>
$viewFile = '/home/website-server/www/app/View/Products/view.ctp'
$dataForView = array(
	'language' => 'en',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'product' => array(
		'Product' => array(
			'id' => '2517',
			'antibody_id' => null,
			'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
			'label1' => '',
			'info1' => '',
			'label2' => '',
			'info2' => '',
			'label3' => '',
			'info3' => '',
			'format' => '50 µl',
			'catalog_number' => 'C17011004-50',
			'old_catalog_number' => 'pp-1004-050',
			'sf_code' => 'C17011004-D001-000014',
			'type' => 'FRE',
			'search_order' => '04-undefined',
			'price_EUR' => '60',
			'price_USD' => '35',
			'price_GBP' => '60',
			'price_JPY' => '9400',
			'price_CNY' => '',
			'price_AUD' => '88',
			'country' => 'ALL',
			'except_countries' => 'None',
			'quote' => false,
			'in_stock' => false,
			'featured' => true,
			'no_promo' => false,
			'online' => true,
			'master' => true,
			'last_datasheet_update' => '0000-00-00',
			'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
			'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'meta_keywords' => '',
			'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'modified' => '2016-10-21 08:17:25',
			'created' => '2015-06-29 14:08:20',
			'locale' => 'eng'
		),
		'Antibody' => array(
			'host' => '*****',
			'id' => null,
			'name' => null,
			'description' => null,
			'clonality' => null,
			'isotype' => null,
			'lot' => null,
			'concentration' => null,
			'reactivity' => null,
			'type' => null,
			'purity' => null,
			'classification' => null,
			'application_table' => null,
			'storage_conditions' => null,
			'storage_buffer' => null,
			'precautions' => null,
			'uniprot_acc' => null,
			'slug' => null,
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => null,
			'created' => null,
			'select_label' => null
		),
		'Slave' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Group' => array(
			'Group' => array(
				[maximum depth reached]
			),
			'Master' => array(
				[maximum depth reached]
			),
			'Product' => array(
				[maximum depth reached]
			)
		),
		'Related' => array(),
		'Application' => array(),
		'Category' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Document' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Feature' => array(),
		'Image' => array(),
		'Promotion' => array(),
		'Protocol' => array(),
		'Publication' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		),
		'Testimonial' => array(),
		'Area' => array(),
		'SafetySheet' => array(
			(int) 0 => array(
				[maximum depth reached]
			),
			(int) 1 => array(
				[maximum depth reached]
			),
			(int) 2 => array(
				[maximum depth reached]
			),
			(int) 3 => array(
				[maximum depth reached]
			),
			(int) 4 => array(
				[maximum depth reached]
			),
			(int) 5 => array(
				[maximum depth reached]
			),
			(int) 6 => array(
				[maximum depth reached]
			),
			(int) 7 => array(
				[maximum depth reached]
			)
		)
	),
	'meta_canonical' => 'https://www.diagenode.com/en/p/human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul'
)
$language = 'en'
$meta_keywords = ''
$meta_description = 'Human  ChIP-seq grade c-fos promoter primer pair'
$meta_title = 'Human  ChIP-seq grade c-fos promoter primer pair'
$product = array(
	'Product' => array(
		'id' => '2517',
		'antibody_id' => null,
		'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
		'label1' => '',
		'info1' => '',
		'label2' => '',
		'info2' => '',
		'label3' => '',
		'info3' => '',
		'format' => '50 µl',
		'catalog_number' => 'C17011004-50',
		'old_catalog_number' => 'pp-1004-050',
		'sf_code' => 'C17011004-D001-000014',
		'type' => 'FRE',
		'search_order' => '04-undefined',
		'price_EUR' => '60',
		'price_USD' => '35',
		'price_GBP' => '60',
		'price_JPY' => '9400',
		'price_CNY' => '',
		'price_AUD' => '88',
		'country' => 'ALL',
		'except_countries' => 'None',
		'quote' => false,
		'in_stock' => false,
		'featured' => true,
		'no_promo' => false,
		'online' => true,
		'master' => true,
		'last_datasheet_update' => '0000-00-00',
		'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
		'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'meta_keywords' => '',
		'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'modified' => '2016-10-21 08:17:25',
		'created' => '2015-06-29 14:08:20',
		'locale' => 'eng'
	),
	'Antibody' => array(
		'host' => '*****',
		'id' => null,
		'name' => null,
		'description' => null,
		'clonality' => null,
		'isotype' => null,
		'lot' => null,
		'concentration' => null,
		'reactivity' => null,
		'type' => null,
		'purity' => null,
		'classification' => null,
		'application_table' => null,
		'storage_conditions' => null,
		'storage_buffer' => null,
		'precautions' => null,
		'uniprot_acc' => null,
		'slug' => null,
		'meta_keywords' => null,
		'meta_description' => null,
		'modified' => null,
		'created' => null,
		'select_label' => null
	),
	'Slave' => array(
		(int) 0 => array(
			'id' => '118',
			'name' => 'C17011004',
			'product_id' => '2517',
			'modified' => '2016-02-19 21:27:26',
			'created' => '2016-02-19 21:27:26'
		)
	),
	'Group' => array(
		'Group' => array(
			'id' => '118',
			'name' => 'C17011004',
			'product_id' => '2517',
			'modified' => '2016-02-19 21:27:26',
			'created' => '2016-02-19 21:27:26'
		),
		'Master' => array(
			'id' => '2517',
			'antibody_id' => null,
			'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
			'label1' => '',
			'info1' => '',
			'label2' => '',
			'info2' => '',
			'label3' => '',
			'info3' => '',
			'format' => '50 µl',
			'catalog_number' => 'C17011004-50',
			'old_catalog_number' => 'pp-1004-050',
			'sf_code' => 'C17011004-D001-000014',
			'type' => 'FRE',
			'search_order' => '04-undefined',
			'price_EUR' => '60',
			'price_USD' => '35',
			'price_GBP' => '60',
			'price_JPY' => '9400',
			'price_CNY' => '',
			'price_AUD' => '88',
			'country' => 'ALL',
			'except_countries' => 'None',
			'quote' => false,
			'in_stock' => false,
			'featured' => true,
			'no_promo' => false,
			'online' => true,
			'master' => true,
			'last_datasheet_update' => '0000-00-00',
			'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul',
			'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'meta_keywords' => '',
			'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
			'modified' => '2016-10-21 08:17:25',
			'created' => '2015-06-29 14:08:20'
		),
		'Product' => array(
			(int) 0 => array(
				[maximum depth reached]
			)
		)
	),
	'Related' => array(),
	'Application' => array(),
	'Category' => array(
		(int) 0 => array(
			'id' => '69',
			'position' => '1',
			'parent_id' => '35',
			'name' => 'Human',
			'description' => '<p>Primer pairs - Human</p>',
			'no_promo' => false,
			'in_menu' => false,
			'online' => true,
			'tabular' => true,
			'hide' => false,
			'all_format' => false,
			'is_antibody' => false,
			'slug' => 'primer-pairs-human',
			'cookies_tag_id' => null,
			'meta_keywords' => 'Primer pairs, human, ChIP-seq grade',
			'meta_description' => 'Diagenode offers Primer pairs for Human ChIP-seq grade',
			'meta_title' => 'Primer pairs - Human | Diagenode',
			'modified' => '2016-10-21 08:00:50',
			'created' => '2015-07-23 15:38:42',
			'ProductsCategory' => array(
				[maximum depth reached]
			),
			'CookiesTag' => array([maximum depth reached])
		)
	),
	'Document' => array(
		(int) 0 => array(
			'id' => '254',
			'name' => 'Datasheet Human cfos promoter pp1004',
			'description' => 'Datasheet description',
			'image_id' => null,
			'type' => 'Datasheet',
			'url' => 'files/products/reagents/primer_pairs/Datasheet_Human_cfos_promoter_pp1004.pdf',
			'slug' => 'datasheet-human-cfos-promoter-pp1004',
			'meta_keywords' => null,
			'meta_description' => null,
			'modified' => '2015-07-07 11:47:43',
			'created' => '2015-07-07 11:47:43',
			'ProductsDocument' => array(
				[maximum depth reached]
			)
		)
	),
	'Feature' => array(),
	'Image' => array(),
	'Promotion' => array(),
	'Protocol' => array(),
	'Publication' => array(
		(int) 0 => array(
			'id' => '2980',
			'name' => 'Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells',
			'authors' => 'Dagdemir A et al.',
			'description' => '<h4>BACKGROUND/AIM:</h4>
<p><abstracttext label="BACKGROUND/AIM" nlmcategory="OBJECTIVE">Numerous studies have shown that breast cancer and epigenetic mechanisms have a very powerful interactive relation. The MCF7 cell line, representative of luminal subtype and the MDA-MB 231 cell line representative of mesenchymal-like subtype were treated respectively with a Histone Methyl Transferase Inhibitors (HMTi), 3-Deazaneplanocin hydrochloride (DZNep), two histone deacetylase inhibitors (HDACi), sodium butyrate (NaBu), and suberoylanilide hydroxamic acid (SAHA) for 48 h.</abstracttext></p>
<h4>MATERIALS AND METHODS:</h4>
<p><abstracttext label="MATERIALS AND METHODS" nlmcategory="METHODS">Chromatin immunoprecipitation (ChIP) was used to observe HDACis (SAHA and NaBu) and HMTi (DZNep) impact on histones and more specifically on H3K27me3, H3K9ac and H3K4ac marks with Q-PCR analysis of BRCA1, SRC3 and P300 genes. Furthermore, the HDACi and HMTi effects on mRNA and protein expression of BRCA1, SRC3 and P300 genes were checked. In addition, statistical analyses were used.</abstracttext></p>
<h4>RESULTS:</h4>
<p><abstracttext label="RESULTS" nlmcategory="RESULTS">In the MCF7 luminal subtype with positive ER, H3k4ac was significantly increased on BRCA1 with SAHA. On the contrary, in the MDA-MB 231 breast cancer cell line, representative of mesenchymal-like subtype with negative estrogen receptor, HDACis had no effect. Also, DZNEP decreased significantly H3K27me3 on BRCA1 in MDA-MB 231. Besides, on SRC3, a significant increase for H3K4ac was obtained in MCF7 treated with SAHA. And DZNEP had no effect in MCF7. Also, in MDA-MB 231 treated with DZNEP, H3K27me3 significantly decreased on SRC3 while H3K4ac was significantly increased in MDA-MB-231 treated with SAHA or NaBu for P300.</abstracttext></p>
<h4>CONCLUSION:</h4>
<p><abstracttext label="CONCLUSION" nlmcategory="CONCLUSIONS">Luminal and mesenchymal-like breast cancer subtype cell lines seemed to act differently to HDACis (SAHA and NaBu) or HMTi (DZNEP) treatments.</abstracttext></p>',
			'date' => '2016-07-01',
			'pmid' => 'http://www.ncbi.nlm.nih.gov/pubmed/27365379',
			'doi' => '',
			'modified' => '2016-07-12 12:50:21',
			'created' => '2016-07-12 12:46:04',
			'ProductsPublication' => array(
				[maximum depth reached]
			)
		)
	),
	'Testimonial' => array(),
	'Area' => array(),
	'SafetySheet' => array(
		(int) 0 => array(
			'id' => '270',
			'name' => 'c-fos Promoter Primer Pair SDS GB en',
			'language' => 'en',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-GB-en-GHS_1_0.pdf',
			'countries' => 'GB',
			'modified' => '2020-06-09 10:33:07',
			'created' => '2020-06-09 10:33:07',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 1 => array(
			'id' => '272',
			'name' => 'c-fos Promoter Primer Pair SDS US en',
			'language' => 'en',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-US-en-GHS_1_0.pdf',
			'countries' => 'US',
			'modified' => '2020-06-09 10:34:22',
			'created' => '2020-06-09 10:34:22',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 2 => array(
			'id' => '267',
			'name' => 'c-fos Promoter Primer Pair SDS DE de',
			'language' => 'de',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-DE-de-GHS_1_0.pdf',
			'countries' => 'DE',
			'modified' => '2020-06-09 10:27:14',
			'created' => '2020-06-09 10:27:14',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 3 => array(
			'id' => '271',
			'name' => 'c-fos Promoter Primer Pair SDS JP ja',
			'language' => 'ja',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-JP-ja-GHS_2_0.pdf',
			'countries' => 'JP',
			'modified' => '2020-06-09 10:33:45',
			'created' => '2020-06-09 10:33:45',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 4 => array(
			'id' => '266',
			'name' => 'c-fos Promoter Primer Pair SDS BE nl',
			'language' => 'nl',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-BE-nl-GHS_1_0.pdf',
			'countries' => 'BE',
			'modified' => '2020-06-09 10:25:59',
			'created' => '2020-06-09 10:25:59',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 5 => array(
			'id' => '265',
			'name' => 'c-fos Promoter Primer Pair SDS BE fr',
			'language' => 'fr',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-BE-fr-GHS_1_0.pdf',
			'countries' => 'BE',
			'modified' => '2020-06-09 10:24:34',
			'created' => '2020-06-09 10:24:34',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 6 => array(
			'id' => '269',
			'name' => 'c-fos Promoter Primer Pair SDS FR fr',
			'language' => 'fr',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-FR-fr-GHS_1_0.pdf',
			'countries' => 'FR',
			'modified' => '2020-06-09 10:29:06',
			'created' => '2020-06-09 10:29:06',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		),
		(int) 7 => array(
			'id' => '268',
			'name' => 'c-fos Promoter Primer Pair SDS ES es',
			'language' => 'es',
			'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-ES-es-GHS_1_0.pdf',
			'countries' => 'ES',
			'modified' => '2020-06-09 10:28:17',
			'created' => '2020-06-09 10:28:17',
			'ProductsSafetySheet' => array(
				[maximum depth reached]
			)
		)
	)
)
$meta_canonical = 'https://www.diagenode.com/en/p/human-chip-seq-grade-c-fos-promoter-primer-pair-50-ul'
$country = 'US'
$countries_allowed = array(
	(int) 0 => 'CA',
	(int) 1 => 'US',
	(int) 2 => 'IE',
	(int) 3 => 'GB',
	(int) 4 => 'DK',
	(int) 5 => 'NO',
	(int) 6 => 'SE',
	(int) 7 => 'FI',
	(int) 8 => 'NL',
	(int) 9 => 'BE',
	(int) 10 => 'LU',
	(int) 11 => 'FR',
	(int) 12 => 'DE',
	(int) 13 => 'CH',
	(int) 14 => 'AT',
	(int) 15 => 'ES',
	(int) 16 => 'IT',
	(int) 17 => 'PT'
)
$outsource = false
$other_formats = array(
	(int) 0 => array(
		'id' => '2518',
		'antibody_id' => null,
		'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
		'label1' => '',
		'info1' => '',
		'label2' => '',
		'info2' => '',
		'label3' => '',
		'info3' => '',
		'format' => '500 µl',
		'catalog_number' => 'C17011004-500',
		'old_catalog_number' => 'pp-1004-500',
		'sf_code' => 'C17011004-D001-000015',
		'type' => 'FRE',
		'search_order' => '04-undefined',
		'price_EUR' => '115',
		'price_USD' => '100',
		'price_GBP' => '105',
		'price_JPY' => '18015',
		'price_CNY' => '',
		'price_AUD' => '250',
		'country' => 'ALL',
		'except_countries' => 'None',
		'quote' => false,
		'in_stock' => false,
		'featured' => true,
		'no_promo' => false,
		'online' => true,
		'master' => false,
		'last_datasheet_update' => '0000-00-00',
		'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
		'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'meta_keywords' => '',
		'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
		'modified' => '2016-02-19 21:27:54',
		'created' => '2015-06-29 14:08:20',
		'ProductsGroup' => array(
			'id' => '129',
			'product_id' => '2518',
			'group_id' => '118'
		)
	)
)
$pro = array(
	'id' => '2518',
	'antibody_id' => null,
	'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
	'label1' => '',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '500 µl',
	'catalog_number' => 'C17011004-500',
	'old_catalog_number' => 'pp-1004-500',
	'sf_code' => 'C17011004-D001-000015',
	'type' => 'FRE',
	'search_order' => '04-undefined',
	'price_EUR' => '115',
	'price_USD' => '100',
	'price_GBP' => '105',
	'price_JPY' => '18015',
	'price_CNY' => '',
	'price_AUD' => '250',
	'country' => 'ALL',
	'except_countries' => 'None',
	'quote' => false,
	'in_stock' => false,
	'featured' => true,
	'no_promo' => false,
	'online' => true,
	'master' => false,
	'last_datasheet_update' => '0000-00-00',
	'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'modified' => '2016-02-19 21:27:54',
	'created' => '2015-06-29 14:08:20',
	'ProductsGroup' => array(
		'id' => '129',
		'product_id' => '2518',
		'group_id' => '118'
	)
)
$edit = ''
$testimonials = ''
$featured_testimonials = ''
$related_products = ''
$rrbs_service = array(
	(int) 0 => (int) 1894,
	(int) 1 => (int) 1895
)
$chipseq_service = array(
	(int) 0 => (int) 2683,
	(int) 1 => (int) 1835,
	(int) 2 => (int) 1836,
	(int) 3 => (int) 2684,
	(int) 4 => (int) 1838,
	(int) 5 => (int) 1839,
	(int) 6 => (int) 1856
)
$labelize = object(Closure) {
	
}
$old_catalog_number = ' <span style="color:#CCC">(pp-1004-500)</span>'
$country_code = 'US'
$other_format = array(
	'id' => '2518',
	'antibody_id' => null,
	'name' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'description' => '<p><span>This primer pair specifically amplifies a genomic region containing the human c-fos promoter. The primers are thoroughly tested and optimized for routine SYBR&reg; Green Real-Time qPCR assay following ChIP and for ChIP-sequencing library validation (e.g. before and after ChIP-seq library preparation).</span></p>',
	'label1' => '',
	'info1' => '',
	'label2' => '',
	'info2' => '',
	'label3' => '',
	'info3' => '',
	'format' => '500 µl',
	'catalog_number' => 'C17011004-500',
	'old_catalog_number' => 'pp-1004-500',
	'sf_code' => 'C17011004-D001-000015',
	'type' => 'FRE',
	'search_order' => '04-undefined',
	'price_EUR' => '115',
	'price_USD' => '100',
	'price_GBP' => '105',
	'price_JPY' => '18015',
	'price_CNY' => '',
	'price_AUD' => '250',
	'country' => 'ALL',
	'except_countries' => 'None',
	'quote' => false,
	'in_stock' => false,
	'featured' => true,
	'no_promo' => false,
	'online' => true,
	'master' => false,
	'last_datasheet_update' => '0000-00-00',
	'slug' => 'human-chip-seq-grade-c-fos-promoter-primer-pair-500-ul',
	'meta_title' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'meta_keywords' => '',
	'meta_description' => 'Human  ChIP-seq grade c-fos promoter primer pair',
	'modified' => '2016-02-19 21:27:54',
	'created' => '2015-06-29 14:08:20',
	'ProductsGroup' => array(
		'id' => '129',
		'product_id' => '2518',
		'group_id' => '118'
	)
)
$label = '<img src="/img/banners/banner-customizer-back.png" alt=""/>'
$document = array(
	'id' => '254',
	'name' => 'Datasheet Human cfos promoter pp1004',
	'description' => 'Datasheet description',
	'image_id' => null,
	'type' => 'Datasheet',
	'url' => 'files/products/reagents/primer_pairs/Datasheet_Human_cfos_promoter_pp1004.pdf',
	'slug' => 'datasheet-human-cfos-promoter-pp1004',
	'meta_keywords' => null,
	'meta_description' => null,
	'modified' => '2015-07-07 11:47:43',
	'created' => '2015-07-07 11:47:43',
	'ProductsDocument' => array(
		'id' => '586',
		'product_id' => '2517',
		'document_id' => '254'
	)
)
$sds = array(
	'id' => '268',
	'name' => 'c-fos Promoter Primer Pair SDS ES es',
	'language' => 'es',
	'url' => 'files/SDS/c-fos_promoter/SDS-C17011004-c-fos_promoter_primer_pair-ES-es-GHS_1_0.pdf',
	'countries' => 'ES',
	'modified' => '2020-06-09 10:28:17',
	'created' => '2020-06-09 10:28:17',
	'ProductsSafetySheet' => array(
		'id' => '502',
		'product_id' => '2517',
		'safety_sheet_id' => '268'
	)
)
$publication = array(
	'id' => '2980',
	'name' => 'Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells',
	'authors' => 'Dagdemir A et al.',
	'description' => '<h4>BACKGROUND/AIM:</h4>
<p><abstracttext label="BACKGROUND/AIM" nlmcategory="OBJECTIVE">Numerous studies have shown that breast cancer and epigenetic mechanisms have a very powerful interactive relation. The MCF7 cell line, representative of luminal subtype and the MDA-MB 231 cell line representative of mesenchymal-like subtype were treated respectively with a Histone Methyl Transferase Inhibitors (HMTi), 3-Deazaneplanocin hydrochloride (DZNep), two histone deacetylase inhibitors (HDACi), sodium butyrate (NaBu), and suberoylanilide hydroxamic acid (SAHA) for 48 h.</abstracttext></p>
<h4>MATERIALS AND METHODS:</h4>
<p><abstracttext label="MATERIALS AND METHODS" nlmcategory="METHODS">Chromatin immunoprecipitation (ChIP) was used to observe HDACis (SAHA and NaBu) and HMTi (DZNep) impact on histones and more specifically on H3K27me3, H3K9ac and H3K4ac marks with Q-PCR analysis of BRCA1, SRC3 and P300 genes. Furthermore, the HDACi and HMTi effects on mRNA and protein expression of BRCA1, SRC3 and P300 genes were checked. In addition, statistical analyses were used.</abstracttext></p>
<h4>RESULTS:</h4>
<p><abstracttext label="RESULTS" nlmcategory="RESULTS">In the MCF7 luminal subtype with positive ER, H3k4ac was significantly increased on BRCA1 with SAHA. On the contrary, in the MDA-MB 231 breast cancer cell line, representative of mesenchymal-like subtype with negative estrogen receptor, HDACis had no effect. Also, DZNEP decreased significantly H3K27me3 on BRCA1 in MDA-MB 231. Besides, on SRC3, a significant increase for H3K4ac was obtained in MCF7 treated with SAHA. And DZNEP had no effect in MCF7. Also, in MDA-MB 231 treated with DZNEP, H3K27me3 significantly decreased on SRC3 while H3K4ac was significantly increased in MDA-MB-231 treated with SAHA or NaBu for P300.</abstracttext></p>
<h4>CONCLUSION:</h4>
<p><abstracttext label="CONCLUSION" nlmcategory="CONCLUSIONS">Luminal and mesenchymal-like breast cancer subtype cell lines seemed to act differently to HDACis (SAHA and NaBu) or HMTi (DZNEP) treatments.</abstracttext></p>',
	'date' => '2016-07-01',
	'pmid' => 'http://www.ncbi.nlm.nih.gov/pubmed/27365379',
	'doi' => '',
	'modified' => '2016-07-12 12:50:21',
	'created' => '2016-07-12 12:46:04',
	'ProductsPublication' => array(
		'id' => '1434',
		'product_id' => '2517',
		'publication_id' => '2980'
	)
)
$externalLink = ' <a href="http://www.ncbi.nlm.nih.gov/pubmed/27365379" target="_blank"><i class="fa fa-external-link"></i></a>'
include - APP/View/Products/view.ctp, line 755
View::_evaluate() - CORE/Cake/View/View.php, line 971
View::_render() - CORE/Cake/View/View.php, line 933
View::render() - CORE/Cake/View/View.php, line 473
Controller::render() - CORE/Cake/Controller/Controller.php, line 963
ProductsController::slug() - APP/Controller/ProductsController.php, line 1052
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 491
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 193
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 167
[main] - APP/webroot/index.php, line 118

Contact Information

First name

Last name

Company

Phone number

City

Country

State

Email verification^*

Comment

Events

See all events

Site map | Contact us | Conditions of sales | Conditions of purchase | Privacy policy

c-fos Promoter Primer Pair SDS GB en	Download
c-fos Promoter Primer Pair SDS US en	Download
c-fos Promoter Primer Pair SDS DE de	Download
c-fos Promoter Primer Pair SDS JP ja	Download
c-fos Promoter Primer Pair SDS BE nl	Download
c-fos Promoter Primer Pair SDS BE fr	Download
c-fos Promoter Primer Pair SDS FR fr	Download
c-fos Promoter Primer Pair SDS ES es	Download