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Other names: KMT1A, MG44
Polyclonal antibody raised in rabbit against human SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1), using two synthetic peptides containing a sequence from the central part and the C-terminus of the protein, respectively.
| Lot | A2892-0011 |
|---|---|
| Concentration | 2.3 µg/µl |
| Species reactivity | Human: positive |
| Type | Polyclonal |
| Purity | Affinity purified polyclonal antibody |
| Host | Rabbit |
| Storage Conditions | Store at -20°C; for long storage, store at -80°C. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.05% azide |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| SUV39H1 polyclonal antibody DATASHEET Polyclonal antibody raised in rabbit against human SUV39H1 (Suppressor Of Variegation 3-9 Homolog... | Download |
| Epigenetic Antibodies Brochure BROCHURE More than in any other immuoprecipitation assays, quality antibodies are critical tools in many e... | Download |
 How to properly cite this product in your workDiagenode strongly recommends using this: SUV39H1 Antibody (sample size) (Diagenode Cat# C15410368-10 Lot# A2892-0011). Click here to copy to clipboard. Using our products in your publication? Let us know! |
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ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. It’s also a component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates silencing of rDNA in response to changes in the intracellular energy status. Loss of function may cause chromosome instability. 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Batch-specific data available on the website. Other names: KMT1A, MG44. Sample size available.', 'modified' => '2022-01-05 14:56:52', 'created' => '2020-08-20 12:34:58' ), 'Product' => array( (int) 0 => array( [maximum depth reached] ) ) ), 'Related' => array(), 'Application' => array(), 'Category' => array( (int) 0 => array( 'id' => '103', 'position' => '0', 'parent_id' => '4', 'name' => 'All antibodies', 'description' => '<p><span style="font-weight: 400;">All Diagenode’s antibodies are listed below. Please, use our Quick search field to find the antibody of interest by target name, application, purity.</span></p> <p><span style="font-weight: 400;">Diagenode’s highly validated antibodies:</span></p> <ul> <li>Highly sensitive and specific</li> <li>Cost-effective (requires less antibody per reaction)</li> <li>Batch-specific data is available on the website</li> <li>Expert technical support</li> <li>Sample sizes available</li> <li>100% satisfaction guarantee</li> </ul>', 'no_promo' => false, 'in_menu' => true, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => false, 'is_antibody' => true, 'slug' => 'all-antibodies', 'cookies_tag_id' => null, 'meta_keywords' => 'Antibodies,Premium Antibodies,Classic,Pioneer', 'meta_description' => 'Diagenode Offers Strict quality standards with Rigorous QC and validated Antibodies. Classified based on level of validation for flexibility of Application. Comprehensive selection of histone and non-histone Antibodies', 'meta_title' => 'Diagenode's selection of Antibodies is exclusively dedicated for Epigenetic Research | Diagenode', 'modified' => '2019-07-03 10:55:44', 'created' => '2015-11-02 14:49:22', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ), (int) 1 => array( 'id' => '21', 'position' => '20', 'parent_id' => '4', 'name' => 'Histone modifying enzymes', 'description' => '<p><span style="font-weight: 400;">Diagenode offers the large number of antibodies raised against histone modifying enzymes. The list below includes the antibodies against enzymes like: histone deacetylases, histone demethylases, histone transferases.</span></p> <p><span style="font-weight: 400;">Diagenode’s highly validated antibodies:</span></p> <ul> <li>Highly sensitive and specific</li> <li>Cost-effective (requires less antibody per reaction)</li> <li>Batch-specific data is available on the website</li> <li>Expert technical support</li> <li>Sample sizes available</li> <li>100% satisfaction guarantee</li> </ul>', 'no_promo' => false, 'in_menu' => false, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => false, 'is_antibody' => true, 'slug' => 'chromatin-modifying-proteins-histone-transferase', 'cookies_tag_id' => null, 'meta_keywords' => 'monoclonal antibodies,policlonal antibodies,Histone modifying enzymes', 'meta_description' => 'Diagenode Offers Polyclonal and Monoclonal Antibodies Against Histone Modifying Enzymes like: Histone Deacetylases, Histone Demethylases, Histone Transferases.', 'meta_title' => 'Histone modifying enzymes - Antibodies | Diagenode', 'modified' => '2019-07-04 16:19:15', 'created' => '2014-06-26 13:18:41', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ), (int) 2 => array( 'id' => '102', 'position' => '1', 'parent_id' => '4', 'name' => 'Sample size antibodies', 'description' => '<h1><strong>Validated epigenetics antibodies</strong> – care for a sample?<br /> </h1> <p>Diagenode has partnered with leading epigenetics experts and numerous epigenetics consortiums to bring to you a validated and comprehensive collection of epigenetic antibodies. As an expert in epigenetics, we are committed to offering highly-specific antibodies validated for ChIP/ChIP-seq and many other applications. All batch-specific validation data is available on our website.<br /><a href="../categories/antibodies">Read about our expertise in antibody production</a>.</p> <ul> <li><strong>Focused</strong> - Diagenode's selection of antibodies is exclusively dedicated for epigenetic research. <a title="See the full collection." href="../categories/all-antibodies">See the full collection.</a></li> <li><strong>Strict quality standards</strong> with rigorous QC and validation</li> <li><strong>Classified</strong> based on level of validation for flexibility of application</li> </ul> <p>Existing sample sizes are listed below. We will soon expand our collection. Are you looking for a sample size of another antibody? Just <a href="mailto:agnieszka.zelisko@diagenode.com?Subject=Sample%20Size%20Request" target="_top">Contact us</a>.</p>', 'no_promo' => false, 'in_menu' => true, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => true, 'is_antibody' => true, 'slug' => 'sample-size-antibodies', 'cookies_tag_id' => null, 'meta_keywords' => '5-hmC monoclonal antibody,CRISPR/Cas9 polyclonal antibody ,H3K36me3 polyclonal antibody,diagenode', 'meta_description' => 'Diagenode offers sample volume on selected antibodies for researchers to test, validate and provide confidence and flexibility in choosing from our wide range of antibodies ', 'meta_title' => 'Sample-size Antibodies | Diagenode', 'modified' => '2019-07-03 10:57:05', 'created' => '2015-10-27 12:13:34', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ) ), 'Document' => array( (int) 0 => array( 'id' => '1095', 'name' => 'SUV39H1 polyclonal antibody', 'description' => '<p>Polyclonal antibody raised in rabbit against human SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1), using two synthetic peptides containing a sequence from the central part and the C-terminus of the protein, respectively.</p>', 'image_id' => null, 'type' => 'Datasheet', 'url' => 'files/products/antibodies/Datasheet_SUV39H1_C15410368.pdf', 'slug' => 'suv39h1-c15410368-pdf', 'meta_keywords' => '', 'meta_description' => '', 'modified' => '2020-08-26 15:48:41', 'created' => '2020-08-26 15:48:41', 'ProductsDocument' => array( [maximum depth reached] ) ), (int) 1 => array( 'id' => '38', 'name' => 'Epigenetic Antibodies Brochure', 'description' => '<p>More than in any other immuoprecipitation assays, quality antibodies are critical tools in many epigenetics experiments. 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ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. 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Batch-specific data available on the website. Other names: KMT1A, MG44. Sample size available.', 'modified' => '2022-01-05 14:57:11', 'created' => '2020-09-10 15:21:50', 'ProductsGroup' => array( 'id' => '324', 'product_id' => '3100', 'group_id' => '286' ) ) $edit = '' $testimonials = '' $featured_testimonials = '' $related_products = '' $rrbs_service = array( (int) 0 => (int) 1894, (int) 1 => (int) 1895 ) $chipseq_service = array( (int) 0 => (int) 2683, (int) 1 => (int) 1835, (int) 2 => (int) 1836, (int) 3 => (int) 2684, (int) 4 => (int) 1838, (int) 5 => (int) 1839, (int) 6 => (int) 1856 ) $labelize = object(Closure) { } $old_catalog_number = '' $country_code = 'US' $other_format = array( 'id' => '3094', 'antibody_id' => '569', 'name' => 'SUV39H1 Antibody', 'description' => '<p><strong>Other names: </strong><span lang="EN-GB">KMT1A, MG44</span></p> <p><span lang="EN-GB">Polyclonal antibody raised in rabbit against human <strong>SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1),</strong> using two synthetic peptides containing a sequence from the central part and the C-terminus of the protein, respectively.</span></p>', 'label1' => 'Validation data', 'info1' => '<div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig1-chip.png" alt="SUV39H1 Antibody ChIP Grade" /></center></div> <div class="small-6 columns"> <p><strong>Figure 1. ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. 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ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. It’s also a component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates silencing of rDNA in response to changes in the intracellular energy status. Loss of function may cause chromosome instability. 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Batch-specific data available on the website. Other names: KMT1A, MG44. Sample size available.', 'modified' => '2022-01-05 14:56:52', 'created' => '2020-08-20 12:34:58' ), 'Product' => array( (int) 0 => array( [maximum depth reached] ) ) ), 'Related' => array(), 'Application' => array(), 'Category' => array( (int) 0 => array( 'id' => '103', 'position' => '0', 'parent_id' => '4', 'name' => 'All antibodies', 'description' => '<p><span style="font-weight: 400;">All Diagenode’s antibodies are listed below. Please, use our Quick search field to find the antibody of interest by target name, application, purity.</span></p> <p><span style="font-weight: 400;">Diagenode’s highly validated antibodies:</span></p> <ul> <li>Highly sensitive and specific</li> <li>Cost-effective (requires less antibody per reaction)</li> <li>Batch-specific data is available on the website</li> <li>Expert technical support</li> <li>Sample sizes available</li> <li>100% satisfaction guarantee</li> </ul>', 'no_promo' => false, 'in_menu' => true, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => false, 'is_antibody' => true, 'slug' => 'all-antibodies', 'cookies_tag_id' => null, 'meta_keywords' => 'Antibodies,Premium Antibodies,Classic,Pioneer', 'meta_description' => 'Diagenode Offers Strict quality standards with Rigorous QC and validated Antibodies. Classified based on level of validation for flexibility of Application. Comprehensive selection of histone and non-histone Antibodies', 'meta_title' => 'Diagenode's selection of Antibodies is exclusively dedicated for Epigenetic Research | Diagenode', 'modified' => '2019-07-03 10:55:44', 'created' => '2015-11-02 14:49:22', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ), (int) 1 => array( 'id' => '21', 'position' => '20', 'parent_id' => '4', 'name' => 'Histone modifying enzymes', 'description' => '<p><span style="font-weight: 400;">Diagenode offers the large number of antibodies raised against histone modifying enzymes. The list below includes the antibodies against enzymes like: histone deacetylases, histone demethylases, histone transferases.</span></p> <p><span style="font-weight: 400;">Diagenode’s highly validated antibodies:</span></p> <ul> <li>Highly sensitive and specific</li> <li>Cost-effective (requires less antibody per reaction)</li> <li>Batch-specific data is available on the website</li> <li>Expert technical support</li> <li>Sample sizes available</li> <li>100% satisfaction guarantee</li> </ul>', 'no_promo' => false, 'in_menu' => false, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => false, 'is_antibody' => true, 'slug' => 'chromatin-modifying-proteins-histone-transferase', 'cookies_tag_id' => null, 'meta_keywords' => 'monoclonal antibodies,policlonal antibodies,Histone modifying enzymes', 'meta_description' => 'Diagenode Offers Polyclonal and Monoclonal Antibodies Against Histone Modifying Enzymes like: Histone Deacetylases, Histone Demethylases, Histone Transferases.', 'meta_title' => 'Histone modifying enzymes - Antibodies | Diagenode', 'modified' => '2019-07-04 16:19:15', 'created' => '2014-06-26 13:18:41', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ), (int) 2 => array( 'id' => '102', 'position' => '1', 'parent_id' => '4', 'name' => 'Sample size antibodies', 'description' => '<h1><strong>Validated epigenetics antibodies</strong> – care for a sample?<br /> </h1> <p>Diagenode has partnered with leading epigenetics experts and numerous epigenetics consortiums to bring to you a validated and comprehensive collection of epigenetic antibodies. As an expert in epigenetics, we are committed to offering highly-specific antibodies validated for ChIP/ChIP-seq and many other applications. All batch-specific validation data is available on our website.<br /><a href="../categories/antibodies">Read about our expertise in antibody production</a>.</p> <ul> <li><strong>Focused</strong> - Diagenode's selection of antibodies is exclusively dedicated for epigenetic research. <a title="See the full collection." href="../categories/all-antibodies">See the full collection.</a></li> <li><strong>Strict quality standards</strong> with rigorous QC and validation</li> <li><strong>Classified</strong> based on level of validation for flexibility of application</li> </ul> <p>Existing sample sizes are listed below. We will soon expand our collection. Are you looking for a sample size of another antibody? Just <a href="mailto:agnieszka.zelisko@diagenode.com?Subject=Sample%20Size%20Request" target="_top">Contact us</a>.</p>', 'no_promo' => false, 'in_menu' => true, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => true, 'is_antibody' => true, 'slug' => 'sample-size-antibodies', 'cookies_tag_id' => null, 'meta_keywords' => '5-hmC monoclonal antibody,CRISPR/Cas9 polyclonal antibody ,H3K36me3 polyclonal antibody,diagenode', 'meta_description' => 'Diagenode offers sample volume on selected antibodies for researchers to test, validate and provide confidence and flexibility in choosing from our wide range of antibodies ', 'meta_title' => 'Sample-size Antibodies | Diagenode', 'modified' => '2019-07-03 10:57:05', 'created' => '2015-10-27 12:13:34', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ) ), 'Document' => array( (int) 0 => array( 'id' => '1095', 'name' => 'SUV39H1 polyclonal antibody', 'description' => '<p>Polyclonal antibody raised in rabbit against human SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1), using two synthetic peptides containing a sequence from the central part and the C-terminus of the protein, respectively.</p>', 'image_id' => null, 'type' => 'Datasheet', 'url' => 'files/products/antibodies/Datasheet_SUV39H1_C15410368.pdf', 'slug' => 'suv39h1-c15410368-pdf', 'meta_keywords' => '', 'meta_description' => '', 'modified' => '2020-08-26 15:48:41', 'created' => '2020-08-26 15:48:41', 'ProductsDocument' => array( [maximum depth reached] ) ), (int) 1 => array( 'id' => '38', 'name' => 'Epigenetic Antibodies Brochure', 'description' => '<p>More than in any other immuoprecipitation assays, quality antibodies are critical tools in many epigenetics experiments. 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ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. 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Batch-specific data available on the website. Other names: KMT1A, MG44. Sample size available.', 'modified' => '2022-01-05 14:57:11', 'created' => '2020-09-10 15:21:50', 'ProductsGroup' => array( 'id' => '324', 'product_id' => '3100', 'group_id' => '286' ) ) $edit = '' $testimonials = '' $featured_testimonials = '' $related_products = '' $rrbs_service = array( (int) 0 => (int) 1894, (int) 1 => (int) 1895 ) $chipseq_service = array( (int) 0 => (int) 2683, (int) 1 => (int) 1835, (int) 2 => (int) 1836, (int) 3 => (int) 2684, (int) 4 => (int) 1838, (int) 5 => (int) 1839, (int) 6 => (int) 1856 ) $labelize = object(Closure) { } $old_catalog_number = '' $country_code = 'US' $other_format = array( 'id' => '3094', 'antibody_id' => '569', 'name' => 'SUV39H1 Antibody', 'description' => '<p><strong>Other names: </strong><span lang="EN-GB">KMT1A, MG44</span></p> <p><span lang="EN-GB">Polyclonal antibody raised in rabbit against human <strong>SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1),</strong> using two synthetic peptides containing a sequence from the central part and the C-terminus of the protein, respectively.</span></p>', 'label1' => 'Validation data', 'info1' => '<div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig1-chip.png" alt="SUV39H1 Antibody ChIP Grade" /></center></div> <div class="small-6 columns"> <p><strong>Figure 1. ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. 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ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. It’s also a component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates silencing of rDNA in response to changes in the intracellular energy status. Loss of function may cause chromosome instability. 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Batch-specific data available on the website. Other names: KMT1A, MG44. Sample size available.', 'modified' => '2022-01-05 14:56:52', 'created' => '2020-08-20 12:34:58' ), 'Product' => array( (int) 0 => array( [maximum depth reached] ) ) ), 'Related' => array(), 'Application' => array(), 'Category' => array( (int) 0 => array( 'id' => '103', 'position' => '0', 'parent_id' => '4', 'name' => 'All antibodies', 'description' => '<p><span style="font-weight: 400;">All Diagenode’s antibodies are listed below. Please, use our Quick search field to find the antibody of interest by target name, application, purity.</span></p> <p><span style="font-weight: 400;">Diagenode’s highly validated antibodies:</span></p> <ul> <li>Highly sensitive and specific</li> <li>Cost-effective (requires less antibody per reaction)</li> <li>Batch-specific data is available on the website</li> <li>Expert technical support</li> <li>Sample sizes available</li> <li>100% satisfaction guarantee</li> </ul>', 'no_promo' => false, 'in_menu' => true, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => false, 'is_antibody' => true, 'slug' => 'all-antibodies', 'cookies_tag_id' => null, 'meta_keywords' => 'Antibodies,Premium Antibodies,Classic,Pioneer', 'meta_description' => 'Diagenode Offers Strict quality standards with Rigorous QC and validated Antibodies. Classified based on level of validation for flexibility of Application. Comprehensive selection of histone and non-histone Antibodies', 'meta_title' => 'Diagenode's selection of Antibodies is exclusively dedicated for Epigenetic Research | Diagenode', 'modified' => '2019-07-03 10:55:44', 'created' => '2015-11-02 14:49:22', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ), (int) 1 => array( 'id' => '21', 'position' => '20', 'parent_id' => '4', 'name' => 'Histone modifying enzymes', 'description' => '<p><span style="font-weight: 400;">Diagenode offers the large number of antibodies raised against histone modifying enzymes. The list below includes the antibodies against enzymes like: histone deacetylases, histone demethylases, histone transferases.</span></p> <p><span style="font-weight: 400;">Diagenode’s highly validated antibodies:</span></p> <ul> <li>Highly sensitive and specific</li> <li>Cost-effective (requires less antibody per reaction)</li> <li>Batch-specific data is available on the website</li> <li>Expert technical support</li> <li>Sample sizes available</li> <li>100% satisfaction guarantee</li> </ul>', 'no_promo' => false, 'in_menu' => false, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => false, 'is_antibody' => true, 'slug' => 'chromatin-modifying-proteins-histone-transferase', 'cookies_tag_id' => null, 'meta_keywords' => 'monoclonal antibodies,policlonal antibodies,Histone modifying enzymes', 'meta_description' => 'Diagenode Offers Polyclonal and Monoclonal Antibodies Against Histone Modifying Enzymes like: Histone Deacetylases, Histone Demethylases, Histone Transferases.', 'meta_title' => 'Histone modifying enzymes - Antibodies | Diagenode', 'modified' => '2019-07-04 16:19:15', 'created' => '2014-06-26 13:18:41', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ), (int) 2 => array( 'id' => '102', 'position' => '1', 'parent_id' => '4', 'name' => 'Sample size antibodies', 'description' => '<h1><strong>Validated epigenetics antibodies</strong> – care for a sample?<br /> </h1> <p>Diagenode has partnered with leading epigenetics experts and numerous epigenetics consortiums to bring to you a validated and comprehensive collection of epigenetic antibodies. As an expert in epigenetics, we are committed to offering highly-specific antibodies validated for ChIP/ChIP-seq and many other applications. All batch-specific validation data is available on our website.<br /><a href="../categories/antibodies">Read about our expertise in antibody production</a>.</p> <ul> <li><strong>Focused</strong> - Diagenode's selection of antibodies is exclusively dedicated for epigenetic research. <a title="See the full collection." href="../categories/all-antibodies">See the full collection.</a></li> <li><strong>Strict quality standards</strong> with rigorous QC and validation</li> <li><strong>Classified</strong> based on level of validation for flexibility of application</li> </ul> <p>Existing sample sizes are listed below. We will soon expand our collection. Are you looking for a sample size of another antibody? Just <a href="mailto:agnieszka.zelisko@diagenode.com?Subject=Sample%20Size%20Request" target="_top">Contact us</a>.</p>', 'no_promo' => false, 'in_menu' => true, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => true, 'is_antibody' => true, 'slug' => 'sample-size-antibodies', 'cookies_tag_id' => null, 'meta_keywords' => '5-hmC monoclonal antibody,CRISPR/Cas9 polyclonal antibody ,H3K36me3 polyclonal antibody,diagenode', 'meta_description' => 'Diagenode offers sample volume on selected antibodies for researchers to test, validate and provide confidence and flexibility in choosing from our wide range of antibodies ', 'meta_title' => 'Sample-size Antibodies | Diagenode', 'modified' => '2019-07-03 10:57:05', 'created' => '2015-10-27 12:13:34', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ) ), 'Document' => array( (int) 0 => array( 'id' => '1095', 'name' => 'SUV39H1 polyclonal antibody', 'description' => '<p>Polyclonal antibody raised in rabbit against human SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1), using two synthetic peptides containing a sequence from the central part and the C-terminus of the protein, respectively.</p>', 'image_id' => null, 'type' => 'Datasheet', 'url' => 'files/products/antibodies/Datasheet_SUV39H1_C15410368.pdf', 'slug' => 'suv39h1-c15410368-pdf', 'meta_keywords' => '', 'meta_description' => '', 'modified' => '2020-08-26 15:48:41', 'created' => '2020-08-26 15:48:41', 'ProductsDocument' => array( [maximum depth reached] ) ), (int) 1 => array( 'id' => '38', 'name' => 'Epigenetic Antibodies Brochure', 'description' => '<p>More than in any other immuoprecipitation assays, quality antibodies are critical tools in many epigenetics experiments. 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ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. 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Batch-specific data available on the website. Other names: KMT1A, MG44. Sample size available.', 'modified' => '2022-01-05 14:57:11', 'created' => '2020-09-10 15:21:50', 'ProductsGroup' => array( 'id' => '324', 'product_id' => '3100', 'group_id' => '286' ) ) $edit = '' $testimonials = '' $featured_testimonials = '' $related_products = '' $rrbs_service = array( (int) 0 => (int) 1894, (int) 1 => (int) 1895 ) $chipseq_service = array( (int) 0 => (int) 2683, (int) 1 => (int) 1835, (int) 2 => (int) 1836, (int) 3 => (int) 2684, (int) 4 => (int) 1838, (int) 5 => (int) 1839, (int) 6 => (int) 1856 ) $labelize = object(Closure) { } $old_catalog_number = '' $country_code = 'US' $other_format = array( 'id' => '3094', 'antibody_id' => '569', 'name' => 'SUV39H1 Antibody', 'description' => '<p><strong>Other names: </strong><span lang="EN-GB">KMT1A, MG44</span></p> <p><span lang="EN-GB">Polyclonal antibody raised in rabbit against human <strong>SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1),</strong> using two synthetic peptides containing a sequence from the central part and the C-terminus of the protein, respectively.</span></p>', 'label1' => 'Validation data', 'info1' => '<div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig1-chip.png" alt="SUV39H1 Antibody ChIP Grade" /></center></div> <div class="small-6 columns"> <p><strong>Figure 1. ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. 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ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. 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Please, use our Quick search field to find the antibody of interest by target name, application, purity.</span></p> <p><span style="font-weight: 400;">Diagenode’s highly validated antibodies:</span></p> <ul> <li>Highly sensitive and specific</li> <li>Cost-effective (requires less antibody per reaction)</li> <li>Batch-specific data is available on the website</li> <li>Expert technical support</li> <li>Sample sizes available</li> <li>100% satisfaction guarantee</li> </ul>', 'no_promo' => false, 'in_menu' => true, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => false, 'is_antibody' => true, 'slug' => 'all-antibodies', 'cookies_tag_id' => null, 'meta_keywords' => 'Antibodies,Premium Antibodies,Classic,Pioneer', 'meta_description' => 'Diagenode Offers Strict quality standards with Rigorous QC and validated Antibodies. Classified based on level of validation for flexibility of Application. Comprehensive selection of histone and non-histone Antibodies', 'meta_title' => 'Diagenode's selection of Antibodies is exclusively dedicated for Epigenetic Research | Diagenode', 'modified' => '2019-07-03 10:55:44', 'created' => '2015-11-02 14:49:22', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ), (int) 1 => array( 'id' => '21', 'position' => '20', 'parent_id' => '4', 'name' => 'Histone modifying enzymes', 'description' => '<p><span style="font-weight: 400;">Diagenode offers the large number of antibodies raised against histone modifying enzymes. The list below includes the antibodies against enzymes like: histone deacetylases, histone demethylases, histone transferases.</span></p> <p><span style="font-weight: 400;">Diagenode’s highly validated antibodies:</span></p> <ul> <li>Highly sensitive and specific</li> <li>Cost-effective (requires less antibody per reaction)</li> <li>Batch-specific data is available on the website</li> <li>Expert technical support</li> <li>Sample sizes available</li> <li>100% satisfaction guarantee</li> </ul>', 'no_promo' => false, 'in_menu' => false, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => false, 'is_antibody' => true, 'slug' => 'chromatin-modifying-proteins-histone-transferase', 'cookies_tag_id' => null, 'meta_keywords' => 'monoclonal antibodies,policlonal antibodies,Histone modifying enzymes', 'meta_description' => 'Diagenode Offers Polyclonal and Monoclonal Antibodies Against Histone Modifying Enzymes like: Histone Deacetylases, Histone Demethylases, Histone Transferases.', 'meta_title' => 'Histone modifying enzymes - Antibodies | Diagenode', 'modified' => '2019-07-04 16:19:15', 'created' => '2014-06-26 13:18:41', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ), (int) 2 => array( 'id' => '102', 'position' => '1', 'parent_id' => '4', 'name' => 'Sample size antibodies', 'description' => '<h1><strong>Validated epigenetics antibodies</strong> – care for a sample?<br /> </h1> <p>Diagenode has partnered with leading epigenetics experts and numerous epigenetics consortiums to bring to you a validated and comprehensive collection of epigenetic antibodies. As an expert in epigenetics, we are committed to offering highly-specific antibodies validated for ChIP/ChIP-seq and many other applications. All batch-specific validation data is available on our website.<br /><a href="../categories/antibodies">Read about our expertise in antibody production</a>.</p> <ul> <li><strong>Focused</strong> - Diagenode's selection of antibodies is exclusively dedicated for epigenetic research. <a title="See the full collection." href="../categories/all-antibodies">See the full collection.</a></li> <li><strong>Strict quality standards</strong> with rigorous QC and validation</li> <li><strong>Classified</strong> based on level of validation for flexibility of application</li> </ul> <p>Existing sample sizes are listed below. We will soon expand our collection. Are you looking for a sample size of another antibody? Just <a href="mailto:agnieszka.zelisko@diagenode.com?Subject=Sample%20Size%20Request" target="_top">Contact us</a>.</p>', 'no_promo' => false, 'in_menu' => true, 'online' => true, 'tabular' => false, 'hide' => true, 'all_format' => true, 'is_antibody' => true, 'slug' => 'sample-size-antibodies', 'cookies_tag_id' => null, 'meta_keywords' => '5-hmC monoclonal antibody,CRISPR/Cas9 polyclonal antibody ,H3K36me3 polyclonal antibody,diagenode', 'meta_description' => 'Diagenode offers sample volume on selected antibodies for researchers to test, validate and provide confidence and flexibility in choosing from our wide range of antibodies ', 'meta_title' => 'Sample-size Antibodies | Diagenode', 'modified' => '2019-07-03 10:57:05', 'created' => '2015-10-27 12:13:34', 'ProductsCategory' => array( [maximum depth reached] ), 'CookiesTag' => array([maximum depth reached]) ) ), 'Document' => array( (int) 0 => array( 'id' => '1095', 'name' => 'SUV39H1 polyclonal antibody', 'description' => '<p>Polyclonal antibody raised in rabbit against human SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1), using two synthetic peptides containing a sequence from the central part and the C-terminus of the protein, respectively.</p>', 'image_id' => null, 'type' => 'Datasheet', 'url' => 'files/products/antibodies/Datasheet_SUV39H1_C15410368.pdf', 'slug' => 'suv39h1-c15410368-pdf', 'meta_keywords' => '', 'meta_description' => '', 'modified' => '2020-08-26 15:48:41', 'created' => '2020-08-26 15:48:41', 'ProductsDocument' => array( [maximum depth reached] ) ), (int) 1 => array( 'id' => '38', 'name' => 'Epigenetic Antibodies Brochure', 'description' => '<p>More than in any other immuoprecipitation assays, quality antibodies are critical tools in many epigenetics experiments. 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ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. It’s also a component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates silencing of rDNA in response to changes in the intracellular energy status. Loss of function may cause chromosome instability. 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Batch-specific data available on the website. Other names: KMT1A, MG44. Sample size available.', 'modified' => '2022-01-05 14:57:11', 'created' => '2020-09-10 15:21:50', 'ProductsGroup' => array( 'id' => '324', 'product_id' => '3100', 'group_id' => '286' ) ) $edit = '' $testimonials = '' $featured_testimonials = '' $related_products = '' $rrbs_service = array( (int) 0 => (int) 1894, (int) 1 => (int) 1895 ) $chipseq_service = array( (int) 0 => (int) 2683, (int) 1 => (int) 1835, (int) 2 => (int) 1836, (int) 3 => (int) 2684, (int) 4 => (int) 1838, (int) 5 => (int) 1839, (int) 6 => (int) 1856 ) $labelize = object(Closure) { } $old_catalog_number = '' $country_code = 'US' $other_format = array( 'id' => '3094', 'antibody_id' => '569', 'name' => 'SUV39H1 Antibody', 'description' => '<p><strong>Other names: </strong><span lang="EN-GB">KMT1A, MG44</span></p> <p><span lang="EN-GB">Polyclonal antibody raised in rabbit against human <strong>SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1),</strong> using two synthetic peptides containing a sequence from the central part and the C-terminus of the protein, respectively.</span></p>', 'label1' => 'Validation data', 'info1' => '<div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig1-chip.png" alt="SUV39H1 Antibody ChIP Grade" /></center></div> <div class="small-6 columns"> <p><strong>Figure 1. ChIP results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP assays were performed using HeLa cells, the Diagenode antibody against SUV39H1 (cat. No. C15410368) and optimized PCR primer sets for qPCR. ChIP was performed with the “iDeal ChIP-seq” kit (cat. No. C01010055), using sheared chromatin from 4 million cells. A titration consisting of 1, 2, 5 and 10 µg of antibody per ChIP experiment was analyzed. IgG (2 µg/IP) was used as a negative IP control. Quantitative PCR was performed with primers for the ADCY5 and EPHA10 genes, as well as a chromosome 2 intergenic region, used as positive controls, and for the MYOD1 gene, used as a negative control. Figure 1 shows the recovery, expressed as a % of input (the relative amount of immunoprecipitated DNA compared to input DNA after qPCR analysis).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-12 columns"> <p>A. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2a-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> <p>B. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2b-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq" /></p> <p>C. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2c-chip-seq.jpg" alt="SUV39H1 Antibody for Chip-seq assay" /></p> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <p>D. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2d-chip-seq.jpg" alt="SUV39H1 Antibody validated in Chip-seq " /></p> <p>E. <img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig2e-chip-seq.jpg" alt="SUV39H1 Antibody Chip-seq Grade " /></p> </div> </div> <div class="row"> <div class="small-12 columns"> <p><strong>Figure 2. ChIP-seq results obtained with the Diagenode antibody directed against SUV39H1</strong><br />ChIP was performed with 5 µg of the Diagenode antibody against SUV39H1 (cat. No. C15410368) on sheared chromatin from 4,000,000 HeLa cells using the “iDeal ChIP-seq” kit as described above. The IP'd DNA was subsequently analysed on an Illumina NovaSeq. The 50 bp tags were aligned to the human genome using the BWA algorithm. Figure 2 shows the signal distribution along the complete sequence and a 3 Mb region of human chromosome 1, (figures 2A and B), in two genomic regions surrounding the ADCY5 and EPHA10 positive control genes (figure 2C and D) and in an intergenic region of chromosome 2 (figure 2E).</p> </div> </div> <div class="extra-spaced"></div> <div class="row"> <div class="small-6 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig3-elisa.png" alt="SUV39H1 Antibody ELISA Validation " /></center></div> <div class="small-6 columns"> <p><strong>Figure 3. Determination of the antibody titer</strong><br />To determine the titer of the antibody, an ELISA was performed using a serial dilution of Diagenode antibody directed against SUV39H1 (cat. No. C15410368). The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 3), the titer of the antibody was estimated to be >1:1,000,000.</p> </div> </div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="extra-spaced"></div> <div class="row"> <div class="small-4 columns"><center><img src="https://www.diagenode.com/img/product/antibodies/c15410368-fig4-wb.jpg" alt="SUV39H1 Antibody validated in Western Blot" /></center></div> <div class="small-8 columns"> <p><strong>Figure 4. Western blot analysis using the Diagenode antibody directed against SUV39H1</strong><br />Whole cell extracts from HeLa cells were analysed by Western blot using the Diagenode antibody against SUV39H1 (cat. No. C15410368) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.</p> </div> </div> <script src="chrome-extension://hhojmcideegachlhfgfdhailpfhgknjm/web_accessible_resources/index.js"></script>', 'label2' => 'Target Description', 'info2' => '<p>SUV39H1 (UniProtKB/Swiss-Prot entry O43463) is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3, thereby playing an essential role in transcriptional gene silencing and heterochromatin formation as well as many other regulatory processes. 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