DNA Methylation

Methylbinding domain protein

The MBD approach is based on the very high affinity of a H6-GST-MBD fusion protein for methylated DNA. This protein consists of the methyl binding domain (MBD) of human MeCP2, as a C-terminal fusion with Glutathione-S-transferase (GST) containing an N-terminal His6-tag. The H6-GST-MBD fusion protein can be used to specifically isolate DNA containing methylated CpGs.

Diagenode’s MethylCap^® kit enables high enrichment of double-stranded DNA and a differential fractionation in function of the methylated CpG density. Fractionation reduces the complexity of samples and makes subsequent next generation sequencing easier. Prior to the MethylCap assay, DNA is first extracted and sheared using the Bioruptor^® Sonicator.

Overview

针对 Methylbinding domain protein 的推荐产品

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Bioruptor® Pico 非接触式超声波破碎仪
C02020010

MethylCap kit
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Auto MethylCap kit

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DNA Methylation

Methylbinding domain protein

Overview

针对 Methylbinding domain protein 的推荐产品

Bioruptor® Pico 非接触式超声波破碎仪

MethylCap kit

Auto MethylCap kit

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