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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Genome-wide chromatin analysis in mature mouse and human spermatozoa.
Published: December, 2013
Abstract: At the end of mammalian spermatogenesis, chromatin in differentiating germ cells is extensively remodeled, with the majority of nucleosomes being r... Read more »
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Bioruptor Bioruptor Plus
The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-...
Published: December, 2013
Abstract: The TGF-β/Smad3 pathway plays a major role in tissue fibrosis, but the precise mechanisms are not fully understood. Here we identified microRNA miR... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Mediator links transcription and DNA repair by facilitating Rad2/XP...
Published: December, 2013
Abstract: Mediator is a large multiprotein complex conserved in all eukaryotes. The crucial function of Mediator in transcription is now largely established.... Read more »
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Bioruptor Chromatin Shearing ChIP-seq
Oral administration of transforming growth factor-β1 (TGF-β1) prote...
Published: November, 2013
Abstract: Inflammatory immune responses play an important role in mucosal homeostasis and gut diseases. Nuclear factor κB (NF-κB), central to the proinflamma... Read more »
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Bioruptor Chromatin Shearing
BORIS/CTCFL is an RNA-binding protein that associates with polysomes.
Published: November, 2013
Abstract: BACKGROUND: BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in t... Read more »
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Bioruptor Cell Lysis
A closed-loop synthetic gene circuit for the treatment of diet-indu...
Published: November, 2013
Abstract: Diet-induced obesity is a lifestyle-associated medical condition that increases the risk of developing cardiovascular disease, type 2 diabetes and ... Read more »
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Bioruptor Bioruptor Plus
Toxoplasma gondii inhibits IFN-γ- and IFN-β-induced host cell STAT1...
Published: November, 2013
Abstract: The IFN-γ response, mediated by the STAT1 transcription factor, is crucial for host defense against the intracellular pathogen Toxoplasma gon... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR IP-Star
A quantitative telomeric chromatin isolation protocol identifies di...
Published: November, 2013
Abstract: Telomere composition changes during tumourigenesis, aging and in telomere syndromes in a poorly defined manner. Here we develop a quantitative telo... Read more »
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Bioruptor Chromatin Shearing
Reactive Oxygen Species Induce Epigenetic Instability through the F...
Published: November, 2013
Abstract: Chronic hepatitis C (CHC) triggers oxidative stress and contributes to the emergence of hepatocellular carcinoma (HCC). We previously reported that... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR IP-Star
The nuclear receptor Rev-erbα controls circadian thermogenic plasti...
Published: November, 2013
Abstract: Circadian oscillation of body temperature is a basic, evolutionarily conserved feature of mammalian biology. In addition, homeostatic pathways allo... Read more »
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Bioruptor Tissue Homogenization
Transcriptome surveillance by selective termination of noncoding RN...
Published: November, 2013
Abstract: Pervasive transcription of eukaryotic genomes stems to a large extent from bidirectional promoters that synthesize mRNA and divergent noncoding RNA... Read more »
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Bioruptor Cell Lysis
The cohesin complex regulates immunoglobulin class switch recombina...
Published: November, 2013
Abstract: Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation-induced cytidine deaminase... Read more »
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IPure kit
Suggestive linkage of familial mesial temporal lobe epilepsy to chr...
Published: November, 2013
Abstract: PURPOSE: To describe the clinical findings in a family with a benign form of mesial temporal lobe epilepsy and to identify the causative genetic fa... Read more »
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DNA shearing Bioruptor
PRH/HHex inhibits the migration of breast and prostate epithelial c...
Published: November, 2013
Abstract: PRH/HHex (proline-rich homeodomain protein) is a transcription factor that controls cell proliferation and cell differentiation in a variety of tis... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Pluripotency factors and Polycomb Group proteins repress aryl hydro...
Published: November, 2013
Abstract: The aryl hydrocarbon receptor (AHR) is a transcription factor and environmental sensor that regulates expression of genes involved in drug-metaboli... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Promoter Hypomethylation of EpCAM-Regulated Bone Morphogenetic Prot...
Published: November, 2013
Abstract: PURPOSE: Epigenetic regulation by promoter methylation plays a key role in tumorigenesis. Our goal was to investigate whether altered DNA methylati... Read more »
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Antibody
Adenovirus precursor pVII protein stability is regulated by its pro...
Published: November, 2013
Abstract: Adenovirus encodes for the pVII protein, which interacts and modulates virus DNA structure in the infected cells. The pVII protein is synthesized a... Read more »
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Bioruptor Cell Lysis Western Blot
ESET methylates UBF at K232/254 and regulates nucleolar heterochrom...
Published: November, 2013
Abstract: The remodeling of chromatin in the nucleolus is important for the control of ribosomal DNA (rDNA) transcription and ribosome biogenesis. Herein, we... Read more »
The polycomb protein Ezh2 regulates differentiation and plasticity ...
Published: November, 2013
Abstract: After antigen encounter by CD4(+) T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivati... Read more »
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Antibody
Structural variation-associated expression changes are paralleled b...
Published: November, 2013
Abstract: UNLABELLED: Copy number variants (CNVs) influence the expression of genes that map not only within the rearrangement, but also to its flanks. To as... Read more »
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Bioruptor Chromatin Shearing ChIP-seq
Drosophila UTX Coordinates with p53 to Regulate ku80 Expression in ...
Published: November, 2013
Abstract: UTX is known as a general factor that activates gene transcription during development. Here, we demonstrate an additional essential role of UTX in ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Dynamic reprogramming of 5-hydroxymethylcytosine during early porci...
Published: November, 2013
Abstract: DNA active demethylation is an important epigenetic phenomenon observed in porcine zygotes, yet its molecular origins are unknown. Our results show... Read more »
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Antibody
Frequent alteration of the protein synthesis of enzymes for glucose...
Published: November, 2013
Abstract: BACKGROUND: Cancer cells show enhanced glycolysis and inhibition of oxidative phosphorylation, even in the presence of sufficient oxygen (aerobic g... Read more »
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Bioruptor Tissue Homogenization
Comparative analysis of affinity-based 5-hydroxymethylation enrichm...
Published: November, 2013
Abstract: The epigenetic modification of 5-hydroxymethylcytosine (5hmC) is receiving great attention due to its potential role in DNA methylation reprogrammi... Read more »
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DNA shearing Bioruptor
High-resolution microbial community reconstruction by integrating s...
Published: November, 2013
Abstract: The emergence of massively parallel sequencing technology has revolutionized microbial profiling, allowing the unprecedented comparison of microbia... Read more »
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DNA shearing Bioruptor
Repression of RNA polymerase I upon stress is caused by inhibition ...
Published: November, 2013
Abstract: Sirtuins are NAD(+)-dependent protein deacetylases that connect metabolism and cellular homeostasis. Here we show that the nuclear Sirtuin SIRT7 ta... Read more »
MAP Kinase Signaling Mediates Phosphorylation of Polycomb Ortholog ...
Published: November, 2013
Abstract: Cbx7 is one of five mammalian orthologs of the Drosophila Polycomb (Pc). Cbx7 recognizes methylated lysine residues on the histone H3 tail and cont... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Integrated analysis of transcript-level regulation of metabolism re...
Published: November, 2013
Abstract: Metabolic diseases and comorbidities represent an ever-growing epidemic where multiple cell types impact tissue homeostasis. Here, the link between... Read more »
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Bioruptor Chromatin Shearing ChIP-seq
LXRs regulate ER stress and inflammation through dynamic modulation...
Published: November, 2013
Abstract: The fatty acyl composition of phospholipids determines the biophysical character of membranes and impacts the function of membrane proteins. Here, ... Read more »
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Master Mix
Insulin-dependent transcriptional control in L6 rat myotubes is ass...
Published: November, 2013
Abstract: Besides its direct metabolic effects, insulin induces transcriptional alterations in its target tissues. However, whether such changes are accompan... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR

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