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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric...
Published: March, 2008
Abstract: The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces cerevisiae. In mice, deficiency for the Sir2 family member SIRT6 l... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Global transcription regulation by DNA topoisomerase I in exponenti...
Published: March, 2008
Abstract: To establish the cellular functions of DNA topoisomerase I-B (Top1p) at a global level, we have determined the expression profiles and histone modi... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
The Friedreich ataxia GAA repeat expansion mutation induces compara...
Published: March, 2008
Abstract: Friedreich ataxia (FRDA) is caused by a homozygous GAA repeat expansion mutation within intron 1 of the FXN gene, leading to reduced expression of ... Read more »
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Antibody
Anti-hypertensive activity of genetically modified soybean seeds ac...
Published: March, 2008
Abstract: Novokinin (Arg-Pro-Leu-Lys-Pro-Trp), which has been designed based on the structure of ovokinin (2-7), significantly reduces the systolic blood pre... Read more »
Improved genome-wide localization by ChIP-chip using double-round T...
Published: March, 2008
Abstract: Chromatin immunoprecipitation combined with DNA microarrays (ChIP-chip) is a powerful technique to detect in vivo protein-DNA interactions. Due to ... Read more »
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Bioruptor Chromatin Shearing
Poising of Escherichia coli RNA polymerase and its release from the...
Published: February, 2008
Abstract: Bacteria must adapt their transcription to overcome the osmotic stress associated with the gastrointestinal tract of their host. This requires the ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Gene transactivation without direct DNA binding defines a novel gai...
Published: February, 2008
Abstract: PML-RARalpha is the causative oncogene in 5% to 10% of the cases of acute myeloid leukemia. At physiological concentrations of retinoic acid, PML-R... Read more »
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Chromatin Shearing ChIP-qPCR
MicroChIP--a rapid micro chromatin immunoprecipitation assay for sm...
Published: February, 2008
Abstract: Chromatin immunoprecipitation (ChIP) is a powerful technique for studying protein-DNA interactions. Drawbacks of current ChIP assays however are a ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody LowCell ChIP kit
A rapid micro chromatin immunoprecipitation assay (microChIP).
Published: January, 2008
Abstract: Interactions of proteins with DNA mediate many critical nuclear functions. Chromatin immunoprecipitation (ChIP) is a robust technique for studying ... Read more »
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Antibody
Intranuclear distribution and local dynamics of RNA polymerase II d...
Published: December, 2007
Abstract: Transcription activation causes dramatic changes in a gene's compaction and macromolecular associations and, in some cases, triggers the translocat... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Interplay of chromatin modifiers on a short basic patch of histone ...
Published: December, 2007
Abstract: Dot1 (Disruptor of telomeric silencing-1) is a histone H3 lysine 79 methyltransferase that contributes to the establishment of heterochromatin boun... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Differential regulation of NAB corepressor genes in Schwann cells.
Published: December, 2007
Abstract: BACKGROUND: Myelination of peripheral nerves by Schwann cells requires not only the Egr2/Krox-20 transactivator, but also the NGFI-A/Egr-binding (N... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
CHD8 associates with human Staf and contributes to efficient U6 RNA...
Published: December, 2007
Abstract: Chromatin remodeling and histone modification are essential for eukaryotic transcription regulation, but little is known about chromatin-modifying ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
The transcription factor snail mediates epithelial to mesenchymal t...
Published: December, 2007
Abstract: The estrogen receptor (ER)-alpha (ESR1) is a key regulatory molecule in mammary epithelial cell development. Loss of ER-alpha in breast cancer is c... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Molecular basis for estrogen receptor alpha deficiency in BRCA1-lin...
Published: November, 2007
Abstract: BACKGROUND: BRCA1-mutant breast tumors are typically estrogen receptor alpha (ER alpha) negative, whereas most sporadic tumors express wild-type BR... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Analysis of transcription, chromatin dynamics and epigenetic change...
Published: November, 2007
Abstract: The ways in which gene transcription is investigated have undergone radical change since the turn of the millennium. Piece-meal approaches focussed... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
The JmjC domain protein Epe1 prevents unregulated assembly and disa...
Published: October, 2007
Abstract: Heterochromatin normally has prescribed chromosomal positions and must not encroach on adjacent regions. We demonstrate that the fission yeast prot... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Heme oxygenase-1 induction by NRF2 requires inactivation of the tra...
Published: October, 2007
Abstract: Oxidative stress activates the transcription factor NRF2, which in turn binds cis-acting antioxidant response element (ARE) enhancers and induces e... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Epigenetic regulation (DNA methylation, histone modifications) of t...
Published: October, 2007
Abstract: The human genes MUC2, MUC5AC, MUC5B and MUC6 are clustered on chromosome 11 and encode large secreted gel-forming mucins. The frequent occurrence o... Read more »
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Antibody
Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 ...
Published: October, 2007
Abstract: Transcriptional regulation of gene expression requires posttranslational modification of histone proteins, which, in concert with chromatin-remodel... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Mallory body formation is associated with epigenetic phenotypic cha...
Published: October, 2007
Abstract: Microarrays were done on the livers of mice fed DDC for 10 weeks, withdrawn 1 month (DDC primed livers) and refed 6 days, and compared with mice fe... Read more »
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Antibody
Protein arginine-methyltransferase-dependent oncogenesis.
Published: October, 2007
Abstract: Enzymes that mediate reversible epigenetic modifications have not only been recognized as key in regulating gene expression and oncogenesis, but al... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Redundancy of chromatin remodeling pathways for the induction of th...
Published: September, 2007
Abstract: Induction of the yeast PHO5 and PHO8 genes leads to a prominent chromatin transition at their promoter regions as a prerequisite for transcription ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Activator-mediated recruitment of the MLL2 methyltransferase comple...
Published: August, 2007
Abstract: MLL-containing complexes methylate histone H3 at lysine 4 (H3K4) and have been implicated in the regulation of transcription. However, it is unclea... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Genome-wide maps of chromatin state in pluripotent and lineage-comm...
Published: August, 2007
Abstract: We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells.... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
NuA4-directed chromatin transactions throughout the Saccharomyces c...
Published: August, 2007
Abstract: Two of the major histone acetyltransferases in Saccharomyces cerevisiae are NuA4 and SAGA, which acetylate histones H4 and H3, respectively. Acetyl... Read more »
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Bioruptor Chromatin Shearing
MTERF3 is a negative regulator of mammalian mtDNA transcription.
Published: July, 2007
Abstract: Regulation of mammalian mtDNA gene expression is critical for altering oxidative phosphorylation capacity in response to physiological demands and ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation assoc...
Published: July, 2007
Abstract: Metabolic bioactivation of polycyclic aromatic hydrocarbons, such as the environmental procarcinogen benzo[a]pyrene, is catalyzed by a cytochrome P... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
E2F activation of S phase promoters via association with HCF-1 and ...
Published: July, 2007
Abstract: E2F transcriptional regulators control human-cell proliferation by repressing and activating the transcription of genes required for cell-cycle pro... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Plasticity of fission yeast CENP-A chromatin driven by relative lev...
Published: July, 2007
Abstract: The histone H3 variant CENP-A assembles into chromatin exclusively at centromeres. The process of CENP-A chromatin assembly is epigenetically regul... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR

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