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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

PTTG1IP Orchestrates Epithelial–Mesenchymal Transition and DNA Dama...
Published: September, 2025
Abstract: Background: Thyroid cancer progression involves cell-state plasticity in the form of epithelial–mesenchymal transition (EMT), and defect... Read more »
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iDeal ChIP-seq Kit for Transcription Factors
Teamwork of clustered low-affinity κB sites and accessory factors r...
Published: September, 2025
Abstract: Non-consensus binding sites of transcription factors (TFs) are often observed within the regulatory elements of genes; however, their effect on... Read more »
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Antibody
XPO1-inhibitor Selinexor induces MGMT expression by activating PKA-...
Published: September, 2025
Abstract: Purpose: The temozolomide (TMZ) resistance mechanisms in MGMT-promoter methylated IDH wildtype glioblastoma (GBM) tumors are poorly ... Read more »
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Antibody
Deep Intronic SVA_E Insertion Identified as the Most Common Pathoge...
Published: September, 2025
Abstract: Background and objectives: Canavan disease (CD) is a neurodegenerative disorder in which biallelic pathogenic variants in ASPA resul... Read more »
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Megaruptor
Epigenomic Heterogeneity of Non-Functional Pancreatic Neuroendocrin...
Published: September, 2025
Abstract: Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) account for the majority of neuroendocrine neoplasms arising in the pancreas and e... Read more »
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Tagmentase
Cyclin-dependent kinase inhibitor 1A mediates mouse line- and fate-...
Published: September, 2025
Abstract: Microglia, the resident macrophages in the central nervous system (CNS), have been intensively studied using rodent genetic models, including the... Read more »
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Tagmentase
Analog epigenetic memory revealed by targeted chromatin editing
Published: September, 2025
Abstract: Cells store information by means of chromatin modifications that persist through cell divisions and can hold gene expression silenced over genera... Read more »
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MagMeDIP kit Antibody True MicroChIP kit
Cell-specific epigenome-wide DNA methylation in peripheral CD4(+) l...
Published: September, 2025
Abstract: Background/aims Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune liver disease, triggered by a complex interplay between gene... Read more »
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Infinium Human MethylationEPIC Array Service
Interactions of the LINE-1 encoded ORF1p with proteins and chromati...
Published: September, 2025
Abstract: Retrotransposons are emerging as novel regulators of embryonic and brain development. We recently demonstrated that the LINE-1–encoded prot... Read more »
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ATAC-seq
Endurance training increases a ubiquitylated form of histone H3 in ...
Published: September, 2025
Abstract: At the onset of training, each exercise session transiently shifts the distribution of histone post-transcriptional modifications (HPTMs) to acti... Read more »
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Antibody
Profiling BRCA1-BRCT interactions and their functional relevance at...
Published: September, 2025
Abstract: BRCA1 (breast cancer-associated protein 1) plays a central role in homologous recombination (HR) through interactions with multiple proteins ac... Read more »
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Antibody
Spatial joint profiling of DNA methylome and transcriptome in tissues
Published: September, 2025
Abstract: The spatial resolution of omics analyses is fundamental to understanding tissue biology1-3. The capacity to spatially profile DNA methylation, ... Read more »
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Tagmentase
Gut microbiota-metabolome remodeling associated with low bone mass:...
Published: September, 2025
Abstract: Background: The gut microbiota is increasingly implicated in the pathogenesis of osteoporosis, but its role in the specific context of fractur... Read more »
Epigenetic markers of lithium response in bipolar disorder: optimiz...
Published: August, 2025
Abstract: Lithium (Li) is the most frequently recommended first-line treatment in bipolar disorder (BD). Nevertheless, response to Li is highly variable b... Read more »
Charting the Multi-level Molecular Response to Palbociclib in ER-Po...
Published: August, 2025
Abstract: The addition of CDK4/6 inhibitors to endocrine therapy has significantly improved outcomes in HR+/HER2-breast cancer. However, variable patient... Read more »
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Tagmentase
Developmental modulation of schizophrenia risk gene methylation in ...
Published: August, 2025
Abstract: Maternal infection during pregnancy has been shown in epidemiological studies to increase the risk of neurodevelopmental disorders, like schizo... Read more »
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Premium RRBS Kit DNA Methylation Profiling (RRBS Service)
Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and...
Published: August, 2025
Abstract: Comprehensive epigenomic studies in multiple myeloma (MM) that unravel the connections between major epigenetic regulators, their intertwined colla... Read more »
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Antibody iDeal ChIP-seq Kit for Histones
De novo assembly and delivery of synthetic megabase-scale human DNA...
Published: August, 2025
Abstract: Epigenetic modifications on natural chromosomes are inherited and maintained in a default state, making it challenging to remove intrinsic mark... Read more »
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Antibody
A brain-shuttled antibody targeting alpha synuclein aggregates for ...
Published: August, 2025
Abstract: Parkinson's disease and multiple system atrophy are members of a class of devastating neurodegenerative diseases called synucleinopathies, whic... Read more »
Lysine-specific demethylase 1 regulates hematopoietic stem cell exp...
Published: August, 2025
Abstract: The lysine-specific demethylase 1 (LSD1) regulates hematopoietic stem cell differentiation and has been identified as a therapeutic target in h... Read more »
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Antibody
Active chromatin marks and up-regulation of FOXC1 in uterine epithe...
Published: August, 2025
Abstract: Advanced maternal age increases the risk of pregnancy complications due, in part, to changes in the uterine environment. Here, we show that uteri... Read more »
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Antibody Microplex Library Preparation kit
Phased genome assemblies and pangenome graphs of human populations ...
Published: August, 2025
Abstract: The selection of a reference sequence in genome analysis is critical, as it serves as the foundation for all downstream analyses. Recently, the... Read more »
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Megaruptor
H3K27me3-mediated epigenetic regulation of TET1 in the eutopic endo...
Published: August, 2025
Abstract: Endometriosis is a common gynecological condition associated with chronic inflammation, epigenetic dysregulation, and infertility. The TET1 gene,... Read more »
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Antibody
DNA methylation at retrotransposons protects the germline by preven...
Published: August, 2025
Abstract: Silencing evolutionary young retrotransposons by cytosine DNA methylation is essential for spermatogenesis, as failure to methylate their promote... Read more »
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CUT&Tag
Evidence of neuronal DNA damage in the brains of patients with Rett...
Published: August, 2025
Abstract: Rett syndrome is characterized by the postnatal loss of neurophysiological function and regression of childhood development. Because the syndrome... Read more »
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Antibody
Beyond the Cut: Long-read sequencing reveals complex genomic and tr...
Published: August, 2025
Abstract: Adeno associated virus (AAV)-mediated delivery of CRISPR associated nucleases (AAV-CRISPR) is a promising solution to treat genetic diseases such a... Read more »
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Tagmentase
H1.3 depletion in AML cells prompts H1.2 redistribution, chromatin ...
Published: July, 2025
Abstract: Linker histone H1 variants play critical, yet distinct, roles in chromatin organization and gene regulation. However, very little is known about ... Read more »
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IPure kit Microplex Library Preparation kit ATAC-seq
A draft UAE-based Arab pangenome reference
Published: July, 2025
Abstract: Pangenomes provide a robust and comprehensive portrayal of genetic diversity in humans, but Arab populations remain underrepresented. We presen... Read more »
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Megaruptor
TransTag enables simple and efficient transgene mapping in zebrafis...
Published: July, 2025
Abstract: Zebrafish has become a preeminent model for developmental biology research, largely due to the ease of transgenesis. Despite widespread usage of tr... Read more »
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Tagmentase
SUMO operates from a unique long tandem repeat to keep innate immun...
Published: July, 2025
Abstract: The SUMO pathway mainly functions to repress innate immunity in myeloid cells. Inactivating sumoylation triggers a strong, noncanonical, type I... Read more »
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Antibody Microplex Library Preparation kit

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