Publications,References

Epigenetic regulation (DNA methylation, histone modifications) of t...
Published: October, 2007

Abstract: The human genes MUC2, MUC5AC, MUC5B and MUC6 are clustered on chromosome 11 and encode large secreted gel-forming mucins. The frequent occurrence o... Read more »

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Antibody

Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 ...
Published: October, 2007

Abstract: Transcriptional regulation of gene expression requires posttranslational modification of histone proteins, which, in concert with chromatin-remodel... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Mallory body formation is associated with epigenetic phenotypic cha...
Published: October, 2007

Abstract: Microarrays were done on the livers of mice fed DDC for 10 weeks, withdrawn 1 month (DDC primed livers) and refed 6 days, and compared with mice fe... Read more »

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Antibody

Protein arginine-methyltransferase-dependent oncogenesis.
Published: October, 2007

Abstract: Enzymes that mediate reversible epigenetic modifications have not only been recognized as key in regulating gene expression and oncogenesis, but al... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Redundancy of chromatin remodeling pathways for the induction of th...
Published: September, 2007

Abstract: Induction of the yeast PHO5 and PHO8 genes leads to a prominent chromatin transition at their promoter regions as a prerequisite for transcription ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Activator-mediated recruitment of the MLL2 methyltransferase comple...
Published: August, 2007

Abstract: MLL-containing complexes methylate histone H3 at lysine 4 (H3K4) and have been implicated in the regulation of transcription. However, it is unclea... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Genome-wide maps of chromatin state in pluripotent and lineage-comm...
Published: August, 2007

Abstract: We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells.... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

NuA4-directed chromatin transactions throughout the Saccharomyces c...
Published: August, 2007

Abstract: Two of the major histone acetyltransferases in Saccharomyces cerevisiae are NuA4 and SAGA, which acetylate histones H4 and H3, respectively. Acetyl... Read more »

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Bioruptor Chromatin Shearing

MTERF3 is a negative regulator of mammalian mtDNA transcription.
Published: July, 2007

Abstract: Regulation of mammalian mtDNA gene expression is critical for altering oxidative phosphorylation capacity in response to physiological demands and ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation assoc...
Published: July, 2007

Abstract: Metabolic bioactivation of polycyclic aromatic hydrocarbons, such as the environmental procarcinogen benzo[a]pyrene, is catalyzed by a cytochrome P... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

E2F activation of S phase promoters via association with HCF-1 and ...
Published: July, 2007

Abstract: E2F transcriptional regulators control human-cell proliferation by repressing and activating the transcription of genes required for cell-cycle pro... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Plasticity of fission yeast CENP-A chromatin driven by relative lev...
Published: July, 2007

Abstract: The histone H3 variant CENP-A assembles into chromatin exclusively at centromeres. The process of CENP-A chromatin assembly is epigenetically regul... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

RNAi-dependent H3K27 methylation is required for heterochromatin fo...
Published: June, 2007

Abstract: Methylated H3K27 is an important mark for Polycomb group (PcG) protein-mediated transcriptional gene silencing (TGS) in multicellular eukaryotes. H... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Notch activation stimulates transient and selective binding of Su(H...
Published: June, 2007

Abstract: The CSL [CBF1/Su(H)/Lag2] proteins [Su(H) in Drosophila] are implicated in repression and activation of Notch target loci. Prevailing models imply ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

CHD4/Mi-2beta activity is required for the positioning of the mesod...
Published: April, 2007

Abstract: Experiments in Xenopus have illustrated the importance of extracellular morphogens for embryonic gene regulation in vertebrates. Much less is known... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Ubiquitylation of histone H2B controls RNA polymerase II transcript...
Published: April, 2007

Abstract: Transcription by RNA polymerase II (polII) is accompanied by dramatic changes in chromatin structure. Numerous enzymatic activities contribute to t... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Carbon nanotube polymer composites for photonic devices
Published: March, 2007

Abstract: We report the fabrication of high optical quality single wall carbon nanotube polyvinyl alcohol composites and their application in nanotube based ... Read more »

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Bioruptor

Identification of novel functional TBP-binding sites and general fa...
Published: February, 2007

Abstract: Our current knowledge of the general factor requirement in transcription by the three mammalian RNA polymerases is based on a small number of model... Read more »

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Antibody

An unmethylated 3' promoter-proximal region is required for efficie...
Published: February, 2007

Abstract: The promoter regions of approximately 40% of genes in the human genome are embedded in CpG islands, CpG-rich regions that frequently extend on the ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Genetic unmasking of an epigenetically silenced microRNA in human c...
Published: February, 2007

Abstract: The mechanisms underlying microRNA (miRNA) disruption in human disease are poorly understood. In cancer cells, the transcriptional silencing of tum... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Modulation of drug-stimulated ATPase activity of human MDR1/P-glyco...
Published: January, 2007

Abstract: MDR1 (multidrug resistance 1)/P-glycoprotein is an ATP-driven transporter which excretes a wide variety of structurally unrelated hydrophobic compo... Read more »

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Liposome Preparation

Reciprocal regulation of p63 by C/EBP delta in human keratinocytes.
Published: January, 2007

Abstract: BACKGROUND: Genetic experiments have clarified that p63 is a key transcription factor governing the establishment and maintenance of multilayered e... Read more »

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Antibody

H3K9 methylation and RNA interference regulate nucleolar organizati...
Published: January, 2007

Abstract: Investigations aimed at identifying regulators of nuclear architecture in Drosophila demonstrated that cells lacking H3K9 methylation and RNA inter... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Epigenetic regulation of histone H3 serine 10 phosphorylation statu...
Published: January, 2007

Abstract: BACKGROUND: The human herpes simplex virus (HSV) host cell factor HCF-1 is a transcriptional coregulator that associates with both histone methyl- ... Read more »

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Bioruptor Tissue Homogenization

JunB is required for endothelial cell morphogenesis by regulating c...
Published: December, 2006

Abstract: The molecular mechanism triggering the organization of endothelial cells (ECs) in multicellular tubules is mechanistically still poorly understood.... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Protein interactions within the Set1 complex and their roles in the...
Published: November, 2006

Abstract: Set1 is the catalytic subunit and the central component of the evolutionarily conserved Set1 complex (Set1C) that methylates histone 3 lysine 4 (H3... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Tsix-mediated epigenetic switch of a CTCF-flanked region of the Xis...
Published: October, 2006

Abstract: Initiation of X inactivation depends on the coordinated expression of the sense/antisense pair Xist/Tsix. We show here that a precisely defined Xis... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Architecture of a polycomb nucleoprotein complex.
Published: October, 2006

Abstract: Polycomb group (PcG) epigenetic silencing proteins act through cis-acting DNA sequences, named Polycomb response elements (PREs). Within PREs, Plei... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Glutaredoxin modulates platelet-derived growth factor-dependent cel...
Published: September, 2006

Abstract: Glutaredoxin (GRX) is a glutathione-disulfide oxidoreductase involved in various cellular functions, including the redox-dependent regulation of ce... Read more »

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Cell Lysis

A profile of methyl-CpG binding domain protein occupancy of hyperme...
Published: September, 2006

Abstract: Methyl-CpG binding domain (MBD) proteins have been shown to couple DNA methylation to transcriptional repression. This biological property suggests... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

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