Publications,References

Epigenetic down-regulation of the HIST1 locus predicts better progn...
Published: October, 2019

Abstract: BACKGROUND: The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously de... Read more »

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IPure kit

Physical and functional interaction between SET1/COMPASS complex co...
Published: October, 2019

Abstract: The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 ... Read more »

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Antibody

17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breas...
Published: October, 2019

Abstract: Heat Shock Factor 1 (HSF1) is a key regulator of gene expression during acute environmental stress that enables the cell survival, which is also in... Read more »

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iDeal ChIP-seq Kit for Transcription Factors

CURLY LEAF regulates micro RNA activity by controlling ARGONAUTE 1 ...
Published: October, 2019

Abstract: CURLY LEAF (CLF) encodes the methyl-transferase sub-unit of the Polycomb Repressor Complex 2 (PRC2), which regulates the expression of target genes... Read more »

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Antibody

Genomic and phenotypic analyses of six offspring of a genome-edited...
Published: October, 2019

Abstract: Genome editing followed by reproductive cloning was previously used to produce two hornless dairy bulls. We crossed one genome-edited dairy bull, h... Read more »

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Megaruptor

Epigenomic signatures underpin the axonal regenerative ability of d...
Published: October, 2019

Abstract: Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The presen... Read more »

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Antibody

Complete Genome Sequence of an Enterohemorrhagic Escherichia coli O...
Published: October, 2019

Abstract: We present the complete genome sequence of an enterohemorrhagic O111:H8 strain. This strain was isolated from a hemolytic-uremic syndrome patient a... Read more »

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Megaruptor

Transcriptional alterations in glioma result primarily from DNA met...
Published: October, 2019

Abstract: In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. H... Read more »

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Antibody

Programmed increases in LXRα induced by paternal alcohol use enhanc...
Published: September, 2019

Abstract: Paternally inherited alterations in epigenetic programming are emerging as relevant factors in numerous disease states, including the growth and me... Read more »

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Bioruptor Plus

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusi...
Published: September, 2019

Abstract: Epigenetic regulators play a critical role in normal and malignant hematopoiesis. Deregulation, including epigenetic deregulation, of the gene clus... Read more »

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iDeal Library Preparation Kit

Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of...
Published: September, 2019

Abstract: During endochondral ossification, the differentiation of proliferating into hypertrophic chondrocytes is a key step determining the pace of bone fo... Read more »

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True MicroChIP kit

Assaying epigenome functions of PRMTs and their substrates.
Published: September, 2019

Abstract: Among the widespread and increasing number of identified post-translational modifications (PTMs), arginine methylation is catalyzed by the protein ... Read more »

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Antibody

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediat...
Published: September, 2019

Abstract: Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The ... Read more »

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Antibody

Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acety...
Published: September, 2019

Abstract: Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (D... Read more »

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Antibody

Functional analyses of a low-penetrance risk variant rs6702619/1p21...
Published: September, 2019

Abstract: Several studies employed the genome-wide association (GWA) analysis of single-nucleotide polymorphisms (SNPs) to identify susceptibility regions in... Read more »

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Antibody

Relationship between osteoporosis and osteoarthritis based on DNA m...
Published: September, 2019

Abstract: : The aim of this study was to investigate the relationship between osteoporosis and osteoarthritis by analyzing the DNA methylation in osteoporosi... Read more »

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Antibody

Improved double-nicking strategies for COL7A1 editing by homologous...
Published: September, 2019

Abstract: Current gene editing approaches for treatment of recessive dystrophic epidermolysis bullosa (RDEB), an inherited, severe form of blistering skin di... Read more »

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Antibody

Improved Double-Nicking Strategies for COL7A1-Editing by Homologous...
Published: September, 2019

Abstract: Current gene-editing approaches for treatment of recessive dystrophic epidermolysis bullosa (RDEB), an inherited, severe form of blistering skin di... Read more »

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Antibody

Cooperation of cancer drivers with regulatory germline variants sha...
Published: September, 2019

Abstract: Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations except for pathognomonic driver-mutations that cannot... Read more »

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iDeal ChIP-seq Kit for Transcription Factors

Residual apoptotic activity of a tumorigenic p53 mutant improves ca...
Published: September, 2019

Abstract: Engineered p53 mutant mice are valuable tools for delineating p53 functions in tumor suppression and cancer therapy. Here, we have introduced the R... Read more »

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Microplex Library Preparation kit

β-Glucan-Induced Trained Immunity Protects against Leishmania brazi...
Published: September, 2019

Abstract: American tegumentary leishmaniasis is a vector-borne parasitic disease caused by Leishmania protozoans. Innate immune cells undergo long-term funct... Read more »

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Antibody

Reactivation of super-enhancers by KLF4 in human Head and Neck Squa...
Published: September, 2019

Abstract: Head and neck squamous cell carcinoma (HNSCC) is a disease of significant morbidity and mortality and rarely diagnosed in early stages. Despite ext... Read more »

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Antibody IP-Star Compact

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic...
Published: September, 2019

Abstract: Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for ma... Read more »

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IP-Star Compact iDeal ChIP-seq Kit for Histones

Preparation of cfMeDIP-seq libraries for methylome profiling of pla...
Published: August, 2019

Abstract: Circulating cell-free DNA (cfDNA) comprises small DNA fragments derived from normal and tumor tissue that are released into the bloodstream. Recent... Read more »

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MagMeDIP kit Antibody IPure kit

BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-n...
Published: August, 2019

Abstract: Therapeutic strategies aiming to leverage anti-tumor immunity are being intensively investigated as they show promising results in cancer therapy. ... Read more »

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Antibody

Human mitochondrial DNA is extensively methylated in a non-CpG context
Published: August, 2019

Abstract: Mitochondrial dysfunction plays critical roles in cancer development and related therapeutic response; however, exact molecular mechanisms remain u... Read more »

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MagMeDIP kit IP-Star Compact

Long-read sequencing and haplotype linkage analysis enabled preimpl...
Published: August, 2019

Abstract: BACKGROUND: Preimplantation genetic testing (PGT) has already been applied in patients known to carry chromosomal structural variants to improve th... Read more »

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Megaruptor

Nucleome Dynamics during Retinal Development.
Published: August, 2019

Abstract: More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhance... Read more »

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Antibody iDeal ChIP-seq Kit for Histones

Silencing of tumor-suppressive NR_023387 in renal cell carcinoma vi...
Published: August, 2019

Abstract: Dysregulation of the epigenetic status of long noncoding RNAs (lncRNAs) has been linked to diverse human diseases including human cancers. However,... Read more »

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Antibody

Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macropha...
Published: August, 2019

Abstract: Macrophage polarization is accompanied by drastic changes in L-arginine metabolism. Two L-arginine catalytic enzymes, iNOS and arginase 1, are well... Read more »

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Antibody

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