Publications,References

Glutathione-S-transferase pi 1(GSTP1) gene silencing in prostate ca...
Published: September, 2011

Abstract: Gene silencing by epigenetic mechanisms is frequent in prostate cancer (PCA). The link between DNA hypermethylation and histone modifications is no... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR Antibody

BRCA1 tumour suppression occurs via heterochromatin-mediated silenc...
Published: September, 2011

Abstract: Mutations in the tumour suppressor gene BRCA1 lead to breast and/or ovarian cancer. Here we show that loss of Brca1 in mice results in transcriptio... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Rapid, massively parallel single-cell drug response measurements vi...
Published: September, 2011

Abstract: A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. H... Read more »

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Master Mix

Silencing of Kruppel-like factor 2 by the histone methyltransferase...
Published: September, 2011

Abstract: The Kruppel-like factor (KLF) proteins are multitasked transcriptional regulators with an expanding tumor suppressor function. KLF2 is one of the p... Read more »

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Antibody H3K27me3 (C15410069)

Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating tran...
Published: September, 2011

Abstract: The COP10-DET1-DDB1 (CDD) complex is an evolutionarily conserved protein complex discovered for its role in the repression of photomorphogenesis in... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Diverse roles of RNA polymerase II-associated factor 1 complex in d...
Published: September, 2011

Abstract: Transcription-coupled repair (TCR) and global genomic repair (GGR) are two pathways of nucleotide excision repair (NER). In Saccharomyces cerevisia... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Regulation of human epidermal stem cell proliferation and senescenc...
Published: September, 2011

Abstract: Human epidermal stem cells transit from a slow cycling to an actively proliferating state to contribute to homeostasis. Both stem cell states diffe... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Genome-wide maps of histone modifications unwind in vivo chromatin ...
Published: September, 2011

Abstract: Using mouse skin, where bountiful reservoirs of synchronized hair follicle stem cells (HF-SCs) fuel cycles of regeneration, we explore how adult SC... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

The transcription factor FOXM1 is a cellular target of the natural ...
Published: September, 2011

Abstract: Transcription factors are proteins that bind specifically to defined DNA sequences to promote gene expression. Targeting transcription factors with... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Disruption of the histone acetyltransferase MYST4 leads to a Noonan...
Published: September, 2011

Abstract: Epigenetic regulation of gene expression, through covalent modification of histones, is a key process controlling growth and development. According... Read more »

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Bioruptor Chromatin Shearing Antibody LowCell ChIP kit

Genome-scale analysis of metazoan replication origins reveals their...
Published: September, 2011

Abstract: In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle. Their genomic organization and their genetic nature rem... Read more »

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Bioruptor Chromatin Shearing

Improved quantitative and qualitative production of single-domain i...
Published: September, 2011

Abstract: Camelidae single domain antibodies (VHHs) have structural and binding features that render them suitable alternatives to conventional IgG antibodie... Read more »

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Bioruptor Cell Lysis

Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B i...
Published: September, 2011

Abstract: The role of epigenetics and significance of aberrant gene regulation in etiology of cancer is a well-established phenomenon. The hallmark of cancer... Read more »

Lineage-specific distribution of high levels of genomic 5-hydroxyme...
Published: September, 2011

Abstract: Methylation of cytosine is a DNA modification associated with gene repression. Recently, a novel cytosine modification, 5-hydroxymethylcytosine (5-... Read more »

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Antibody

Smad3-mediated upregulation of miR-21 promotes renal fibrosis.
Published: September, 2011

Abstract: TGF-β/Smad signaling plays a role in fibrogenesis, but therapies targeting TGF-β are ineffective in treating renal fibrosis. Here, we explored the ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

PROMoter uPstream Transcripts share characteristics with mRNAs and ...
Published: September, 2011

Abstract: PROMoter uPstream Transcripts (PROMPTs) were identified as a new class of human RNAs, which are heterologous in length and produced only upstream o... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Effects of genome architecture and epigenetic factors on susceptibi...
Published: September, 2011

Abstract: Aberrant DNA methylation is induced at specific promoter CpG islands (CGIs) in contrast with mutations. The specificity is influenced by genome arc... Read more »

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Antibody

High-throughput sequencing of complete human mtDNA genomes from the...
Published: September, 2011

Abstract: To investigate the demographic history of human populations from the Caucasus and surrounding regions, we used high-throughput sequencing to genera... Read more »

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DNA shearing Bioruptor

Coactivation of GR and NFKB alters the repertoire of their binding ...
Published: September, 2011

Abstract: Glucocorticoid receptor (GR) exerts anti-inflammatory action in part by antagonizing proinflammatory transcription factors such as the nuclear fact... Read more »

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Antibody

Differential patterns of intronic and exonic DNA regions with respe...
Published: August, 2011

Abstract: ABSTRACT: BACKGROUND: The generation of mature mRNAs involves interconnected processes, including transcription by RNA polymerase II (Pol II), mod... Read more »

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Bioruptor Chromatin Shearing

Anthracyclines induce the accumulation of mutant p53 through E2F1-d...
Published: August, 2011

Abstract: Mutant p53 frequently accumulates in cancer cells and promotes tumor cell invasion, as part of its gain of function. Its accumulation is partially ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and A...
Published: August, 2011

Abstract: Alternative splicing and post-translational modifications are processes that give rise to the complexity of the proteome. The nuclear ATF7 and ATF2... Read more »

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Bioruptor Cell Lysis Bioruptor Plus

Selective autophagy regulates insertional mutagenesis by the Ty1 re...
Published: August, 2011

Abstract: Macroautophagy (autophagy) is a bulk degradation system for cytoplasmic components and is ubiquitously found in eukaryotic cells. Autophagy is indu... Read more »

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Antibody

SIRT6 is required for maintenance of telomere position effect in hu...
Published: August, 2011

Abstract: In Saccharomyces cerevisiae, the repressive chromatin environment at telomeres gives rise to telomere position effect (TPE), the epigenetic silenci... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Exome sequencing identifies a DYNC1H1 mutation in a large pedigree ...
Published: August, 2011

Abstract: Charcot-Marie-Tooth disease is characterized by length-dependent axonal degeneration with distal sensory loss and weakness, deep-tendon-reflex abno... Read more »

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DNA shearing Bioruptor

The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase an...
Published: August, 2011

Abstract: The human tumour antigen PRAME (preferentially expressed antigen of melanoma) is frequently overexpressed in tumours. High PRAME levels correlate w... Read more »

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Bioruptor Chromatin Shearing ChIP-seq Antibody

Carboxyl-terminal truncated HBx regulates a distinct microRNA trans...
Published: August, 2011

Abstract: BACKGROUND: The biological pathways and functional properties by which misexpressed microRNAs (miRNAs) contribute to liver carcinogenesis have been... Read more »

The X-inactivation trans-activator Rnf12 is negatively regulated by...
Published: August, 2011

Abstract: X-inactivation, the molecular mechanism enabling dosage compensation in mammals, is tightly controlled during mouse early embryogenesis. In the mor... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

EVI1-mediated down regulation of MIR449A is essential for the survi...
Published: August, 2011

Abstract: Chromosomal rearrangements involving the MECOM (MDS1 and EVI1 complex) locus are recurrent genetic events in myeloid leukaemia and are associated w... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR HighCell ChIP kit

Polycomb eviction as a new distant enhancer function.
Published: August, 2011

Abstract: Remote distal enhancers may be located tens or thousands of kilobases away from their promoters. How they control gene expression is still poorly u... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

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