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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic re...
Published: April, 2013
Abstract: Liver fibrosis is a reversible wound-healing response involving TGFβ1/SMAD activation of hepatic stellate cells (HSCs). It results from excessive d... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
An Orally Bioavailable Chemical Probe of the Lysine Methyltransfera...
Published: April, 2013
Abstract: EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27). The trimethy... Read more »
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Antibody
Mechanism of Polycomb recruitment to CpG islands revealed by inheri...
Published: April, 2013
Abstract: How the transcription repressing complex Polycomb interacts with transcriptional regulators at housekeeping genes in somatic cells is not well unde... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
The response of human macrophages to β-glucans depends on the infla...
Published: April, 2013
Abstract: BACKGROUND: β-glucans are fungal cell wall components that bind to the C-type lectin-like receptor dectin-1. Polymorphisms of dectin-1 gene are ass... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Hypersensitive site 6 of the Th2 locus control region is essential ...
Published: April, 2013
Abstract: The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is con... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
The developmental epigenomics toolbox: ChIP-seq and MethylCap-seq p...
Published: April, 2013
Abstract: Genome-wide profiling of DNA methylation and histone modifications answered many questions as to how the genes are regulated on a global scale and ... Read more »
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DNA shearing Bioruptor Chromatin Shearing ChIP-seq Antibody MethylCap H3K4me3 (C15410003)
Estradiol represses the G(D3) synthase gene ST8SIA1 expression in h...
Published: April, 2013
Abstract: Recent data have underlined a possible role of G(D3) synthase (GD3S) and complex gangliosides in Estrogen Receptor (ER) negative breast cancer prog... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
MTA3 regulates CGB5 and Snail genes in trophoblast.
Published: April, 2013
Abstract: Secreted by the placental trophoblast, human chorionic gonadotropin (hCG) is an important hormone during pregnancy and is required for the maintena... Read more »
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LowCell ChIP kit
Association between living environment and human oral viral ecology.
Published: April, 2013
Abstract: The human oral cavity has an indigenous microbiota known to include a robust community of viruses. Very little is known about how oral viruses are ... Read more »
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DNA shearing Bioruptor
The complete targeted profile of the organic acid intermediates of ...
Published: April, 2013
Abstract: The quantitative profiling of the organic acid intermediates of the citric acid cycle (CAC) presents a challenge due to the lack of commercially av... Read more »
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Cell Lysis Mass Spectrometry
Nuclear retention of the transcription factor NLP7 orchestrates the...
Published: April, 2013
Abstract: Nitrate is both an important nutrient and a signalling molecule for plants. Although several components of the nitrate signalling pathway have been... Read more »
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IPure kit
Multiple mechanisms of action of pyridoxine in primary hyperoxaluri...
Published: April, 2013
Abstract: Primary hyperoxaluria type 1 (PH1) is a rare hereditary calcium oxalate kidney stone disease caused by a deficiency of the liver-specific pyridoxal... Read more »
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Bioruptor Cell Lysis
Gain-of-function mutant p53 downregulates miR-223 contributing to c...
Published: April, 2013
Abstract: Mutant p53 proteins are expressed at high frequency in human tumors and are associated with poor clinical prognosis and resistance to chemotherapeu... Read more »
Retinoic acid represses invasion and stem cell phenotype by inducti...
Published: April, 2013
Abstract: The mouse haematopoietic stem cell (SC) regulator Latexin (LXN) is the only known homologue of the retinoic acid receptor responder 1 (RARRES1) gen... Read more »
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Bioruptor Cell Lysis Western Blot
The histone demethylase Jmjd3 sequentially associates with the tran...
Published: April, 2013
Abstract: Stem cell differentiation depends on transcriptional activation driven by lineage-specific regulators as well as changes in chromatin organization.... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Exit from pluripotency is gated by intracellular redistribution of ...
Published: April, 2013
Abstract: Factors that sustain self-renewal of mouse embryonic stem cells (ESCs) are well described. In contrast, the machinery regulating exit from pluripot... Read more »
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Bioruptor Chromatin Shearing ChIP-seq
Methylation-dependent and -independent genomic targeting principles...
Published: April, 2013
Abstract: To gain insight into the cellular readout of DNA methylation, we established a strategy for systematically profiling the genome-wide distribution o... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
A Culture-Independent Sequence-Based Metage nomics Approach to the ...
Published: April, 2013
Abstract: Importance Identification of the bacterium responsible for an outbreak can aid in disease management. However, traditional culture-based diagnos... Read more »
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DNA shearing Bioruptor
Distinct roles for Sir2 and RNAi in centromeric heterochromatin nuc...
Published: April, 2013
Abstract: Epigenetically regulated heterochromatin domains govern essential cellular activities. A key feature of heterochromatin domains is the presence of ... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipo...
Published: April, 2013
Abstract: The enzyme acyl-CoA synthetase 1 (ACSL1) is induced by peroxisome proliferator-activated receptor α (PPARα) and PPARγ in insulin target tissues, su... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Functional variants at the 11q13 risk locus for breast cancer regul...
Published: April, 2013
Abstract: Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-r... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Utx is required for proper induction of ectoderm and mesoderm durin...
Published: April, 2013
Abstract: Embryonic development requires chromatin remodeling for dynamic regulation of gene expression patterns to ensure silencing of pluripotent transcrip... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody
Akt kinase targets the association of CBP with histone H3 to regula...
Published: April, 2013
Abstract: CREB binding protein (CBP) is an acetyltransferase that plays an important role in many biological processes. Here, we show that Akt phosphorylates... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Genome-wide analysis of LXRα activation reveals new transcriptional...
Published: April, 2013
Abstract: Increased physiological levels of oxysterols are major risk factors for developing atherosclerosis and cardiovascular disease. Lipid-loaded macroph... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR ChIP-seq Antibody H3K4me3 (C15410003)
A systemic transcriptome analysis reveals the regulation of neural ...
Published: April, 2013
Abstract: Stem cell fate decisions are controlled by a molecular network in which transcription factors and miRNAs are of key importance. To systemically inv... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Control of human adenovirus type 5 gene expression by cellular Daxx...
Published: April, 2013
Abstract: Death domain-associated protein (Daxx) cooperates with X-linked α-thalassaemia retardation syndrome protein (ATRX), a putative member of the sucros... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR
Modulation of gene expression via overlapping binding sites exerted...
Published: April, 2013
Abstract: ZNF143 is a zinc-finger protein involved in the transcriptional regulation of both coding and non-coding genes from polymerase II and III promoters... Read more »
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Bioruptor Chromatin Shearing ChIP-seq
Genome-wide comparison of DNA hydroxymethylation in mouse embryonic...
Published: April, 2013
Abstract: The genome-wide distribution patterns of the '6th base' 5-hydroxymethylcytosine (5hmC) in many tissues and cells have recently been revealed by hyd... Read more »
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DNA shearing Bioruptor
Multiple functions of Kip-related protein5 connect endoreduplicatio...
Published: April, 2013
Abstract: Despite considerable progress in our knowledge regarding the cell cycle inhibitor of the Kip-related protein (KRP) family in plants, less is known ... Read more »
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Bioruptor Chromatin Shearing ChIP-seq IPure kit
A pseudogene long-noncoding-RNA network regulates PTEN transcriptio...
Published: April, 2013
Abstract: PTEN is a tumor-suppressor gene that has been shown to be under the regulatory control of a PTEN pseudogene expressed noncoding RNA, PTENpg1. Here,... Read more »
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Bioruptor Chromatin Shearing ChIP-qPCR

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