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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation
Published: March, 2017
Abstract: CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-γ under Th1 polarizing conditions. We hypothesized that this phenotype is ... Read more »
Trimethylation and Acetylation of β-Catenin at Lysine 49 Represent ...
Published: March, 2017
Abstract: Wnt/β-catenin signaling is required for embryonic stem cell (ESC) pluripotency by inducing mesodermal differentiation and inhibiting neuronal ... Read more »
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Antibody
Chd7 is indispensable for mammalian brain development through activ...
Published: March, 2017
Abstract: Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helic... Read more »
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Antibody
Islet-1 induces the differentiation of mesenchymal stem cells into ...
Published: March, 2017
Abstract: Previous studies from this group demonstrated that insulin gene enhancer binding protein ISL-1 (Islet-1) specifically induces the differentiation o... Read more »
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Bioruptor
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of...
Published: March, 2017
Abstract: Methylation of lysine residues on histone tail is a dynamic epigenetic modification that plays a key role in chromatin structure and gene regulatio... Read more »
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Antibody
Decoupling of DNA methylation and activity of intergenic LINE-1 pro...
Published: March, 2017
Abstract: Hypomethylation of LINE-1 repeats in cancer has been proposed as the main mechanism behind their activation; this assumption, however, was based on... Read more »
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Antibody
miR-30a as Potential Therapeutics by Targeting TET1 through Regulat...
Published: March, 2017
Abstract: Several recent studies have indicated that miR-30a plays critical roles in various biological processes and diseases. However, the mechanism of miR... Read more »
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Antibody
Functional variation in allelic methylomes underscores a strong gen...
Published: March, 2017
Abstract: BACKGROUND: The functional impact of genetic variation has been extensively surveyed, revealing that genetic changes correlated to phenotypes li... Read more »
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IP-Star Compact
ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a C...
Published: March, 2017
Abstract: We investigated the relationship among ERK signaling, histone modifications, and transcription factor activity, focusing on the ERK-regulated terna... Read more »
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Antibody
First landscape of binding to chromosomes for a domesticated marine...
Published: March, 2017
Abstract: Setmar is a 3-exons gene coding a SET domain fused to a Hsmar1 transposase. Its different transcripts theoretically encode 8 isoforms with SET moie... Read more »
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Microplex Library Preparation kit
Connexin43 controls N-cadherin transcription during collective cell...
Published: March, 2017
Abstract: Connexins are the primary components of gap junctions, providing direct links between cells in many physiological processes, including cell migrati... Read more »
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Antibody
Crebbp loss cooperates with Bcl2 over-expression to promote lymphom...
Published: March, 2017
Abstract: CREBBP is targeted by inactivating mutations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Here, we provide evidence from ... Read more »
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ChIP-seq IP-Star IP-Star Compact Microplex Library Preparation kit
Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resi...
Published: March, 2017
Abstract: Fibroblast growth factor 21 (FGF21) has emerged as an important beneficial regulator of glucose and lipid homeostasis but its levels are also abnor... Read more »
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Antibody
Krüppel-like transcription factor KLF10 suppresses TGFβ-induced epi...
Published: March, 2017
Abstract: TGFβ-SMAD signaling exerts a contextual effect that suppresses malignant growth early in epithelial tumorigenesis but promotes metastasis at l... Read more »
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Antibody
Assessing histone demethylase inhibitors in cells: lessons learned
Published: March, 2017
Abstract: Background Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and their ... Read more »
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Antibody
Conserved effect of aging on DNA methylation and association with E...
Published: February, 2017
Abstract: In humans, DNA methylation at specific CpG sites can be used to estimate the 'epigenetic clock', a biomarker of aging and health. The mechanisms th... Read more »
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MethylCap
Aorta macrophage inflammatory and epigenetic changes in a murine mo...
Published: February, 2017
Abstract: Obstructive sleep apnea (OSA) affects 8-10% of the population, is characterized by chronic intermittent hypoxia (CIH), and causally associates with... Read more »
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Antibody Microplex Library Preparation kit True MicroChIP kit
Type I interferon-enhanced IL-10 expression in human CD4 T cells is...
Published: February, 2017
Abstract: Type I IFN can exert pro- and anti-inflammatory activities in the immune system. Here, we have investigated the mechanism by which IFN-α enha... Read more »
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IPure kit
Inactivation of Lsd1 triggers senescence in trophoblast stem cells ...
Published: February, 2017
Abstract: Coordination of energy metabolism is essential for homeostasis of stem cells, whereas an imbalance in energy homeostasis causes disease and acceler... Read more »
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IP-Star Compact
An endoparasitoid wasp influences host DNA methylation
Published: February, 2017
Abstract: Parasitism by endoparasitoid wasps changes the expression of various host genes, and alters host immune and developmental processes. However, it is... Read more »
Intestinal NCoR1, a regulator of epithelial cell maturation, contro...
Published: February, 2017
Abstract: Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-gl... Read more »
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Microplex Library Preparation kit
H3.Y discriminates between HIRA and DAXX chaperone complexes and re...
Published: February, 2017
Abstract: Histone chaperones prevent promiscuous histone interactions before chromatin assembly. They guarantee faithful deposition of canonical histones and... Read more »
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Antibody Microplex Library Preparation kit
Overexpression of LINE-1 Retrotransposons in Autism Brain
Published: February, 2017
Abstract: Long interspersed nuclear elements-1 (LINE-1 or L1) are mobile DNA sequences that are capable of duplication and insertion (retrotransposition) wit... Read more »
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MagMeDIP kit
The Drosophila speciation factor HMR localizes to genomic insulator...
Published: February, 2017
Abstract: Hybrid incompatibility between Drosophila melanogaster and D. simulans is caused by a lethal interaction of the proteins encoded by the Hmr and Lhr... Read more »
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Microplex Library Preparation kit
RNF40 regulates gene expression in an epigenetic context-dependent ...
Published: February, 2017
Abstract: BACKGROUND: Monoubiquitination of H2B (H2Bub1) is a largely enigmatic histone modification that has been linked to transcriptional elongation. B... Read more »
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Antibody
Jmjd2c/Kdm4c facilitates the assembly of essential enhancer-protein...
Published: February, 2017
Abstract: Jmjd2 H3K9 demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity. However, little is known about their importance at the exi... Read more »
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Antibody
Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) o...
Published: February, 2017
Abstract: Both Reelin (RELN) and glutamate decarboxylase 67 (GAD1) have been implicated in the pathophysiology of Autism Spectrum Disorders (ASD). We have pr... Read more »
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Antibody
The non-coding variant rs1800734 enhances DCLK3 expression through ...
Published: February, 2017
Abstract: Genome-wide association studies have identified a great number of non-coding risk variants for colorectal cancer (CRC). To date, the majority of th... Read more »
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Antibody
Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27...
Published: February, 2017
Abstract: Although Men1 is a well-known tumour suppressor gene, little is known about the functions of Menin, the protein it encodes for. Since few years, nu... Read more »
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Antibody
Foxa2, a novel protein partner of tumour suppressor menin, is dereg...
Published: February, 2017
Abstract: Foxa2, known as one of the pioneer factors, plays a crucial role in islet development and endocrine functions. Its expression and biological functi... Read more »

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