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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Evaluating the Feasibility of DNA Methylation Analyses Using Long-T...
Published: December, 2016
Abstract: We here characterize the usability of archival formalin-fixed paraffin-embedded (FFPE) brain tissue as a resource for genetic and DNA methylation a... Read more »
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Bioruptor MagMeDIP kit IP-Star Compact
Co-occurrence of Histone H3 K27M and BRAF V600E mutations in paedia...
Published: December, 2016
Abstract: Ganglioglioma (GG) is a grade I tumour characterized by alterations in the MAPK pathway, including BRAF V600E mutation. Recently, diffuse midline g... Read more »
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Antibody
Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9...
Published: December, 2016
Abstract: The functionality of stem cells declines during ageing, and this decline contributes to ageing-associated impairments in tissue regeneration and fu... Read more »
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Antibody
Nitric oxide modulates histone acetylation at stress genes by inhib...
Published: December, 2016
Abstract: Histone acetylation, which is an important mechanism to regulate gene expression, is controlled by the opposing action of histone acetyltransferase... Read more »
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Bioruptor Antibody IPure kit Microplex Library Preparation kit
Alu repeats as transcriptional regulatory platforms in macrophage r...
Published: December, 2016
Abstract: To understand the epigenetic regulation of transcriptional response of macrophages during early-stage M. tuberculosis (Mtb) infection, we performed... Read more »
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Bioruptor
Voluntary Physical Exercise Induces Expression and Epigenetic Remod...
Published: December, 2016
Abstract: A healthy lifestyle, including regular physical exercise, is generally believed to improve cognitive function and enhance neurogenesis. Such physic... Read more »
Epigenetic Networks Regulate the Transcriptional Program in Memory ...
Published: December, 2016
Abstract: Epigenetic mechanisms play a critical role during differentiation of T cells by contributing to the formation of stable and heritable transcription... Read more »
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ChIP-seq
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic ...
Published: December, 2016
Abstract: Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring ... Read more »
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Antibody
FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of ...
Published: December, 2016
Abstract: FOXA1 is a pioneer factor that binds to enhancer regions that are enriched in H3K4 mono- and dimethylation (H3K4me1 and H3K4me2). We performed a FO... Read more »
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Antibody
Immunometabolic Pathways in BCG-Induced Trained Immunity
Published: December, 2016
Abstract: The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term m... Read more »
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Antibody
A transcription factor pulse can prime chromatin for heritable tran...
Published: December, 2016
Abstract: Short-term and long-term transcriptional memory is the phenomenon whereby the kinetics or magnitude of gene induction is enhanced following a prior... Read more »
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Antibody
Distinct and Shared Determinants of Cardiomyocyte Contractility in ...
Published: December, 2016
Abstract: The realization of personalized medicine through human induced pluripotent stem cell (iPSC) technology can be advanced by transcriptomics, epigenom... Read more »
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Bioruptor IP-Star Compact
Potent and selective bivalent inhibitors of BET bromodomains
Published: December, 2016
Abstract: Proteins of the bromodomain and extraterminal (BET) family, in particular bromodomain-containing protein 4 (BRD4), are of great interest as biologi... Read more »
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Antibody
Lhx2 interacts with the NuRD complex and regulates cortical neuron ...
Published: December, 2016
Abstract: n the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated n... Read more »
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Antibody
Genomic Characterization of Metformin Hepatic Response
Published: November, 2016
Abstract: Metformin is used as a first-line therapy for type 2 diabetes (T2D) and prescribed for numerous other diseases. However, its mechanism of action in... Read more »
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LowCell ChIP kit IPure kit
ING1 regulates rRNA levels by altering nucleolar chromatin structur...
Published: November, 2016
Abstract: Epigenetic, transcriptional and signaling processes in the nucleolus regulate rRNA transcription and cell growth. We report here that the tumor sup... Read more »
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Antibody
Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk...
Published: November, 2016
Abstract: The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental gene regulation in multicellular organisms. PRC1 and PRC2 modi... Read more »
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Antibody
Gene regulatory networks in neural cell fate acquisition from genom...
Published: November, 2016
Abstract: Neural cell fate acquisition is mediated by transcription factors expressed in nascent neuroectoderm, including Geminin and members of the Zic tran... Read more »
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Antibody
Genome-wide epigenomic profiling for biomarker discovery
Published: November, 2016
Abstract: A myriad of diseases is caused or characterized by alteration of epigenetic patterns, including changes in DNA methylation, post-translational hist... Read more »
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IP-Star Compact
Genome-wide DNA methylation analysis identifies MEGF10 as a novel e...
Published: November, 2016
Abstract: Neuroblastoma is a childhood cancer in which many children still have poor outcomes, emphasising the need to better understand its pathogenesis. De... Read more »
TET-dependent regulation of retrotransposable elements in mouse emb...
Published: November, 2016
Abstract: BACKGROUND: Ten-eleven translocation (TET) enzymes oxidise DNA methylation as part of an active demethylation pathway. Despite extensive researc... Read more »
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Bioruptor Antibody
Genetic Drivers of Epigenetic and Transcriptional Variation in Huma...
Published: November, 2016
Abstract: Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics a... Read more »
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Antibody IP-Star Compact
β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological...
Published: November, 2016
Abstract: Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure... Read more »
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Bioruptor Antibody
EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells
Published: November, 2016
Abstract: The cellular plasticity of pluripotent stem cells is thought to be sustained by genomic regions that display both active and repressive chromatin p... Read more »
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Bioruptor Antibody
Genome-wide DNA promoter methylation and transcriptome analysis in ...
Published: November, 2016
Abstract: Objective/methods DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter met... Read more »
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Bioruptor MagMeDIP kit
The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-...
Published: November, 2016
Abstract: The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated ... Read more »
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Bioruptor Antibody
Activation of GPER suppresses migration and angiogenesis of triple ...
Published: November, 2016
Abstract: Triple-negative breast cancer (TNBC) are characterized by high vascularity and frequent metastasis. Here, we found that activation of G protein-cou... Read more »
Reader domain specificity and lysine demethylase-4 family function
Published: November, 2016
Abstract: The KDM4 histone demethylases are conserved epigenetic regulators linked to development, spermatogenesis and tumorigenesis. However, how the KDM4 f... Read more »
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Antibody
Enhanced CRISPR/Cas9-mediated precise genome editing by improved de...
Published: November, 2016
Abstract: While CRISPR-based gene knock out in mammalian cells has proven to be very efficient, precise insertion of genetic elements via the cellular homolo... Read more »
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Antibody
Biphasic regulation of chondrocytes by Rela through induction of an...
Published: November, 2016
Abstract: In vitro studies have shown that Rela/p65, a key subunit mediating NF-κB signalling, is involved in chondrogenic differentiation, cell surviv... Read more »

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