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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Genome-wide epigenomic profiling for biomarker discovery
Published: November, 2016
Abstract: A myriad of diseases is caused or characterized by alteration of epigenetic patterns, including changes in DNA methylation, post-translational hist... Read more »
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IP-Star Compact
Genome-wide DNA methylation analysis identifies MEGF10 as a novel e...
Published: November, 2016
Abstract: Neuroblastoma is a childhood cancer in which many children still have poor outcomes, emphasising the need to better understand its pathogenesis. De... Read more »
TET-dependent regulation of retrotransposable elements in mouse emb...
Published: November, 2016
Abstract: BACKGROUND: Ten-eleven translocation (TET) enzymes oxidise DNA methylation as part of an active demethylation pathway. Despite extensive researc... Read more »
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Bioruptor Antibody
Genetic Drivers of Epigenetic and Transcriptional Variation in Huma...
Published: November, 2016
Abstract: Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics a... Read more »
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Antibody IP-Star Compact
β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological...
Published: November, 2016
Abstract: Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure... Read more »
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Bioruptor Antibody
EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells
Published: November, 2016
Abstract: The cellular plasticity of pluripotent stem cells is thought to be sustained by genomic regions that display both active and repressive chromatin p... Read more »
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Bioruptor Antibody
Genome-wide DNA promoter methylation and transcriptome analysis in ...
Published: November, 2016
Abstract: Objective/methods DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter met... Read more »
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Bioruptor MagMeDIP kit
The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-...
Published: November, 2016
Abstract: The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated ... Read more »
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Bioruptor Antibody
Activation of GPER suppresses migration and angiogenesis of triple ...
Published: November, 2016
Abstract: Triple-negative breast cancer (TNBC) are characterized by high vascularity and frequent metastasis. Here, we found that activation of G protein-cou... Read more »
Reader domain specificity and lysine demethylase-4 family function
Published: November, 2016
Abstract: The KDM4 histone demethylases are conserved epigenetic regulators linked to development, spermatogenesis and tumorigenesis. However, how the KDM4 f... Read more »
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Antibody
Enhanced CRISPR/Cas9-mediated precise genome editing by improved de...
Published: November, 2016
Abstract: While CRISPR-based gene knock out in mammalian cells has proven to be very efficient, precise insertion of genetic elements via the cellular homolo... Read more »
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Antibody
Biphasic regulation of chondrocytes by Rela through induction of an...
Published: November, 2016
Abstract: In vitro studies have shown that Rela/p65, a key subunit mediating NF-κB signalling, is involved in chondrogenic differentiation, cell surviv... Read more »
TET2 binds the androgen receptor and loss is associated with prosta...
Published: November, 2016
Abstract: Genetic alterations associated with prostate cancer (PCa) may be identified by sequencing metastatic tumour genomes to identify molecular markers a... Read more »
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Antibody
A set of novel automated quantitative microproteomics protocols for...
Published: November, 2016
Abstract: Here we assessed the ability of an automated sample preparation device equipped with disposable microcolumns to prepare mass-limited samples for hi... Read more »
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Bioruptor Mass Spectrometry
Transcriptional Activation of Pericentromeric Satellite Repeats and...
Published: November, 2016
Abstract: Heterochromatinisation of pericentromeres, which in mice consist of arrays of major satellite repeats, are important for centromere formation and m... Read more »
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Bioruptor IPure kit
Chromatin Preparation and Chromatin Immuno-precipitation from Droso...
Published: November, 2016
Abstract: This protocol provides specific details on how to perform Chromatin immunoprecipitation (ChIP) from Drosophila embryos. ChIP allows the matching of... Read more »
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Antibody
Iterative Fragmentation Improves the Detection of ChIP-seq Peaks fo...
Published: October, 2016
Abstract: As chromatin immunoprecipitation (ChIP) sequencing is becoming the dominant technique for studying chromatin modifications, new protocols surface t... Read more »
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Bioruptor Antibody
Genetic variation at the 8q24.21 renal cancer susceptibility locus ...
Published: October, 2016
Abstract: Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel-Lindau tumour suppressor (VHL) and unrestrained acti... Read more »
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Bioruptor Antibody
DNA methylation and alcohol use disorders: Progress and challenges
Published: October, 2016
Abstract: Background and Objectives Risk for alcohol use disorders (AUDs) is influenced by gene–environment interactions. Environmental factors can ... Read more »
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Premium RRBS Kit
Analysis of Cohesin Function in Gene Regulation and Chromatin Organ...
Published: October, 2016
Abstract: Cohesin is essential for the maintenance of chromosomes through the cell cycle. In addition, cohesin contributes to the regulation of gene expressi... Read more »
Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentia...
Published: October, 2016
Abstract: The transcription factor Foxo3 plays a crucial role in myeloid cell function but its role in lymphoid cells remains poorly defined. Here, we have s... Read more »
Chronic stress leads to epigenetic dysregulation in the neuropeptid...
Published: October, 2016
Abstract: Persistent stress triggers a variety of mechanisms, which may ultimately lead to the occurrence of anxiety- and depression-related disorders. Epige... Read more »
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Antibody
Regulation of transcriptional elongation in pluripotency and cell d...
Published: October, 2016
Abstract: Pluripotent embryonic stem cells (ESCs) self-renew or differentiate into all tissues of the developing embryo and cell-specification factors are ne... Read more »
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Antibody
In vivo conditional deletion of HDAC7 reveals its requirement to es...
Published: October, 2016
Abstract: Class IIa histone deacetylase (HDAC) subfamily members are tissue-specific gene repressors with crucial roles in development and differentiation pr... Read more »
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LowCell ChIP kit True MicroChIP kit
Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse E...
Published: October, 2016
Abstract: In human ESCs the transcription factor Zeb2 regulates neuroectoderm versus mesendoderm formation, but it is unclear how Zeb2 affects the global tra... Read more »
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Premium RRBS Kit
DNA fragmentation and quality control analysis
Published: September, 2016
Abstract: Optimal data generation using NGS platforms relies on a few sample-preparation prerequisites, namely, precise DNA fragmentation, size-range an... Read more »
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DNA shearing Bioruptor
The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 ...
Published: September, 2016
Abstract: Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across m... Read more »
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HighCell ChIP kit IPure kit
Novel regional age-associated DNA methylation changes within human ...
Published: September, 2016
Abstract: BACKGROUND: Advancing age progressively impacts on risk and severity of chronic disease. It also modifies the epigenome, with changes in DNA met... Read more »
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MagMeDIP kit 5mC (C15200081)
Deficient expression of JMJD1A histone demethylase in patients with...
Published: September, 2016
Abstract: JMJD1A (jumonji domain-containing 1A), a known histone H3K9 demethylase, has been identified as a critical epigenetic regulator in male germ cells,... Read more »
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Histone ChIP kit
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted E...
Published: September, 2016
Abstract: Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retro... Read more »
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Bioruptor MagMeDIP kit IPure kit

イベント

  • FASEB Biological Methylation: Fundamental Mechanisms
    Porto, Portugal
    Jul 28-Aug 1, 2024
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