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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Loss of cohesin complex components STAG2 or STAG3 confers resistanc...
Published: August, 2016
Abstract: The protein kinase B-Raf proto-oncogene, serine/threonine kinase (BRAF) is an oncogenic driver and therapeutic target in melanoma. Inhibitors of BR... Read more »
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Antibody
Hormetic Shifting of Redox Environment by Pro-Oxidative Resveratrol...
Published: August, 2016
Abstract: Resveratrol has gained tremendous interest owing to multiple reported health-beneficial effects. However, the underlying key mechanism of action of... Read more »
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Antibody
Enhancer decommissioning by Snail1-induced competitive displacement...
Published: August, 2016
Abstract: Transcriptional silencing is a major cause for the inactivation of tumor suppressor genes, however, the underlying mechanisms are only poorly under... Read more »
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Antibody
Comparative DNA Methylation and Gene Expression Analysis Identifies...
Published: August, 2016
Abstract: Aims For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, ep... Read more »
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MethylCap
Normal stroma suppresses cancer cell proliferation via mechanosensi...
Published: August, 2016
Abstract: Tissue homeostasis is dependent on the controlled localization of specific cell types and the correct composition of the extracellular stroma. Whil... Read more »
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Antibody
Severe muscle wasting and denervation in mice lacking the RNA-bindi...
Published: August, 2016
Abstract: Innervation of skeletal muscle by motor neurons occurs through the neuromuscular junction, a cholinergic synapse essential for normal muscle growth... Read more »
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Antibody
Molecular and epigenetic features of melanomas and tumor immune m...
Published: August, 2016
Abstract: Background Ipilimumab (Ipi) improves the survival of advanced melanoma patients with an incremental long-term benefit in 10–15 % of p... Read more »
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MethylCap
Role of CREB on heme oxygenase-1 induction in adrenal cells: involv...
Published: August, 2016
Abstract: In addition to the well-known function of ACTH as the main regulator of adrenal steroidogenesis, we have previously demonstrated its effect on the ... Read more »
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Antibody
RNA polymerase II promoter-proximal pausing in mammalian long non-c...
Published: August, 2016
Abstract: Mammalian genomes encode a large number of non-coding RNAs (ncRNAs) that greatly exceed mRNA genes. While the physiological and pathological roles ... Read more »
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IP-Star Compact
Epigenetic dynamics of monocyte-to-macrophage differentiation
Published: July, 2016
Abstract: BACKGROUND: Monocyte-to-macrophage differentiation involves major biochemical and structural changes. In order to elucidate the role of gene reg... Read more »
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Antibody IP-Star Compact
Integrative epigenomic analysis reveals unique epigenetic signature...
Published: July, 2016
Abstract: Background Germline stem cells play an essential role in establishing the fertility of an organism. Although extensively characterized, the regu... Read more »
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MethylCap
Converging disease genes in ICF syndrome: ZBTB24 controls expressio...
Published: July, 2016
Abstract: For genetically heterogeneous diseases a better understanding of how the underlying gene defects are functionally interconnected will be important ... Read more »
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Bioruptor Antibody
Genome-wide DNA methylation profiling with MeDIP-seq using archived...
Published: July, 2016
Abstract: Background In utero and early-life experienced environmental exposures are suggested to play an important role in many multifactorial diseases pote... Read more »
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Bioruptor IP-Star MeDIP kit IPure kit
Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epider...
Published: July, 2016
Abstract: The genome-wide localization and function of endogenous Dnmt3a and Dnmt3b in adult stem cells are unknown. Here, we show that in human epidermal st... Read more »
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Antibody
Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organoge...
Published: July, 2016
Abstract: Renal hypoplasia is a common cause of pediatric renal failure and several adult-onset diseases. Recent studies have associated a variant of the OSR... Read more »
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Antibody
Induction of cell differentiation activates transcription of the Sa...
Published: July, 2016
Abstract: The Sarco/Endoplasmic Reticulum Ca2+ -ATPases (SERCAs), pump Ca2+ into the endoplasmic reticulum lumen modulating cytosolic Ca2+ concentrations to ... Read more »
H3K4 acetylation, H3K9 acetylation and H3K27 methylation in breast ...
Published: July, 2016
Abstract: AIM: Here, we investigated how the St Gallen breast molecular subtypes displayed distinct histone H3 profiles. PATIENTS & METHODS: 192 bre... Read more »
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Antibody IP-Star Compact
Combined analysis of DNA methylome and transcriptome reveal novel c...
Published: July, 2016
Abstract: Subclinical mastitis is a widely spread disease of lactating cows. Its major pathogen is Staphylococcus aureus (S. aureus). In this study, we perfo... Read more »
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Antibody
Characterization of the replication timing program of 6 human model...
Published: July, 2016
Abstract: During the S-phase, the DNA replication process is finely orchestrated and regulated by two programs: the spatial program that determines where rep... Read more »
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IP-Star Compact
5-hydroxymethylcytosine marks postmitotic neural cells in the adult...
Published: July, 2016
Abstract: The epigenetic mark 5-hydroxymethylcytosine (5hmC) is a cytosine modification that is abundant in the central nervous system of mammals and which r... Read more »
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Antibody
H4K5 histone acetylation of BRG1 is associated with heroin administ...
Published: July, 2016
Abstract: Diacetylmorphine hydrochloride (heroin) addiction is a chronic relapsing brain disorder that is a heavy public health burden worldwide. Brm/SWI2-re... Read more »
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IP-Star Compact
MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML
Published: July, 2016
Abstract: Homeobox genes are known to be key factors in leukemogenesis. Although the TALE family homeodomain factor Meis1 has been linked to malignancy, a ro... Read more »
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Antibody
Regulation of the DNA Methylation Landscape in Human Somatic Cell R...
Published: July, 2016
Abstract: Reprogramming to pluripotency after overexpression of OCT4, SOX2, KLF4, and MYC is accompanied by global genomic and epigenomic changes. Histone mo... Read more »
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IP-Star Antibody
Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloprolifer...
Published: July, 2016
Abstract: Myeloproliferative neoplasm (MPN) patients frequently show co-occurrence of JAK2-V617F and mutations in epigenetic regulator genes, including EZH2.... Read more »
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True MicroChIP kit
Epigenetic silencing of serine protease HTRA1 drives polyploidy
Published: July, 2016
Abstract: BACKGROUND: Increased numbers and improperly positioned centrosomes, aneuploidy or polyploidy, and chromosomal instability are frequently observ... Read more »
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Antibody
Regulatory Interaction between the Cellular Restriction Factor IFI1...
Published: July, 2016
Abstract: A key player in the intrinsic resistance against human cytomegalovirus (HCMV) is the interferon-γ-inducible protein 16 (IFI16), which behaves... Read more »
DNA demethylation of inflammasome-associated genes is enhanced in p...
Published: July, 2016
Abstract: BACKGROUND: Inflammasomes are cytosolic multiprotein complexes in macrophages. They assemble after infection- or stress-associated stimuli, activa... Read more »
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LowCell ChIP kit
RAB25 expression is epigenetically downregulated in oral and oropha...
Published: July, 2016
Abstract: Oral and oropharyngeal squamous cell carcinoma (OOSCC) have a low survival rate, mainly due to metastasis to the regional lymph nodes. For optimal ... Read more »
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MethylCap
Methylation of the Sox9 and Oct4 promoters and its correlation with...
Published: July, 2016
Abstract: Sox9 and Oct4 are two important regulatory factors involved in mammalian development. Sox9, a member of the group E Sox transcription factor family... Read more »
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Antibody
UMI-4C for quantitative and targeted chromosomal contact profiling
Published: July, 2016
Abstract: We developed a targeted chromosome conformation capture (4C) approach that uses unique molecular identifiers (umis) to derive high-complexity quant... Read more »
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Bioruptor

イベント

  • FASEB Biological Methylation: Fundamental Mechanisms
    Porto, Portugal
    Jul 28-Aug 1, 2024
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