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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Rebalancing gene haploinsufficiency in vivo by targeting chromatin
Published: June, 2016
Abstract: Congenital heart disease (CHD) affects eight out of 1,000 live births and is a major social and health-care burden. A common genetic cause of CHD i... Read more »
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True MicroChIP kit
Heat shock represses rRNA synthesis by inactivation of TIF-IA and l...
Published: June, 2016
Abstract: Attenuation of ribosome biogenesis in suboptimal growth environments is crucial for cellular homeostasis and genetic integrity. Here, we show that ... Read more »
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Antibody
Aberrant DNA methylation of WNT pathway genes in the development an...
Published: May, 2016
Abstract: The WNT signaling pathway has an essential role in colorectal carcinogenesis and progression, which involves a cascade of genetic and epigenetic ch... Read more »
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IP-Star Compact
Epigenetic inactivation of the CpG demethylase TET1 as a DNA methyl...
Published: May, 2016
Abstract: Promoter CpG methylation is a fundamental regulatory process of gene expression. TET proteins are active CpG demethylases converting 5-methylcytosi... Read more »
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Antibody 5mC (C15200081)
PHF13 is a molecular reader and transcriptional co-regulator of H3K...
Published: May, 2016
Abstract: PHF13 is a chromatin affiliated protein with a functional role in differentiation, cell division, DNA damage response and higher chromatin order. T... Read more »
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Antibody
Impairment of DNA Methylation Maintenance Is the Main Cause of Glob...
Published: May, 2016
Abstract: Global demethylation is part of a conserved program of epigenetic reprogramming to naive pluripotency. The transition from primed hypermethylated e... Read more »
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Microplex Library Preparation kit
Molecular mechanisms in H2O2-induced increase in AT1 receptor gene ...
Published: May, 2016
Abstract: The AT1 receptor (AT1R) mediates the manifold actions of Angiotensin II in the cardiovascular system. This study probed the molecular mechanisms th... Read more »
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LowCell ChIP kit
Functional incompatibility between the generic NF-κB motif and a su...
Published: May, 2016
Abstract: Of the various genetic subtypes of HIV-1, HIV-2 and SIV, only in subtype C of HIV-1, a genetically variant NF-κB binding site is found at the... Read more »
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Antibody
mTOR transcriptionally and post-transcriptionally regulates Npm1 ge...
Published: May, 2016
Abstract: The mammalian target of rapamycin (mTOR) plays essential roles in the regulation of growth-related processes such as protein synthesis, cell sizing... Read more »
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Antibody
Genic DNA methylation drives codon bias in stony corals
Published: May, 2016
Abstract: Gene body methylation (gbM) is an ancestral and widespread feature in Eukarya, yet its adaptive value and evolutionary implications remain unresolv... Read more »
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MethylCap
Persistent Alterations in Microglial Enhancers in a Model of Chroni...
Published: May, 2016
Abstract: Chronic pain is a common and devastating condition that induces well-characterized changes in neurons and microglia. One major unanswered question ... Read more »
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True MicroChIP kit
Epigenetic alterations of CYP19A1 gene in Cumulus cells and its rel...
Published: May, 2016
Abstract: PURPOSE: The purpose of the present study was to investigate the epigenetic mechanisms responsible for the aberrant aromatase expression (CYP19A... Read more »
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LowCell ChIP kit
RESEARCH RESOURCE: Changes in gene expression and Estrogen Receptor...
Published: May, 2016
Abstract: Transcriptional regulation by the Estrogen Receptor α (ER) has been investigated mainly in breast cancer cell lines but estrogens such as 17&... Read more »
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Antibody
MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Emb...
Published: May, 2016
Abstract: Numerous developmentally regulated genes in mouse embryonic stem cells (ESCs) are marked by both active (H3K4me3)- and polycomb group (PcG)-mediate... Read more »
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Antibody
PKC-mediated phosphorylation of BCL11B at Serine 2 negatively regul...
Published: May, 2016
Abstract: The transcription factor BCL11B/CTIP2 is a major regulatory protein implicated in various aspects of development, function and survival of T cells.... Read more »
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Antibody
Osterix and RUNX2 are Transcriptional Regulators of Sclerostin in H...
Published: May, 2016
Abstract: Sclerostin, encoded by the SOST gene, works as an inhibitor of the Wnt pathway and therefore is an important regulator of bone homeostasis. Due to ... Read more »
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Bioruptor ChIP-seq LowCell ChIP kit Article alert
EZH2 is overexpressed in adrenocortical carcinoma and is associated...
Published: May, 2016
Abstract: Adrenal Cortex Carcinoma (ACC) is an aggressive tumour with poor prognosis. Common alterations in patients include constitutive WNT/β-catenin ... Read more »
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Antibody
Aflatoxin B1 induces persistent epigenomic effects in primary human...
Published: May, 2016
Abstract: Chronic exposure to aflatoxin B1 (AFB1) has, in certain regions in the world, been strongly associated with hepatocellular carcinoma (HCC) developm... Read more »
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MagMeDIP kit Article alert
Kaiso mediates human ICR1 methylation maintenance and H19 transcrip...
Published: May, 2016
Abstract: Background Genomic imprinting evolved in a common ancestor to marsupials and eutherian mammals and ensured the transcription of developmentally ... Read more »
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Antibody
Characterization of novel Bovine Leukemia Virus (BLV) antisense tra...
Published: May, 2016
Abstract: Background Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T cell leukemia virus-1 (HTLV-1). Cattle are the natural ... Read more »
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Bioruptor
KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic ...
Published: May, 2016
Abstract: The endoplasmic reticulum (ER) unfolded protein response (UPR(er)) pathway plays an important role in helping pancreatic β cells to adapt thei... Read more »
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True MicroChIP kit
Alteration of Gene Expression, DNA Methylation, and Histone Methyla...
Published: May, 2016
Abstract: The molecular basis of Fetal Alcohol Spectrum Disorders (FASD) is poorly understood; however, epigenetic and gene expression changes have been impl... Read more »
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Antibody
PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenot...
Published: April, 2016
Abstract: AIM: Platelet-activating factor acetyl hydrolase 1B1 (PAFAH1B1, also known as Lis1) is a protein essentially involved in neurogenesis and mostly s... Read more »
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Antibody
Mutations in GAS8, A Gene Encoding A Nexin-Dynein Regulatory Comple...
Published: April, 2016
Abstract: Primary ciliary dyskinesia (PCD) is an autosomal recessive disease characterized by chronic respiratory infections of the upper and lower airways, ... Read more »
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Bioruptor Article alert
Three Novel Heterozygous Point Mutations of NR3C1 causing Glucocort...
Published: April, 2016
Abstract: Generalized glucocorticoid resistance is associated with glucocorticoid receptor (GR, NR3C1) mutations. Three novel heterozygous missense NR3C1 mut... Read more »
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Antibody
Genome-wide non-CpG methylation of the host genome during M. tuberc...
Published: April, 2016
Abstract: A mammalian cell utilizes DNA methylation to modulate gene expression in response to environmental changes during development and differentiation. ... Read more »
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IP-Star Compact
Chromatin immunoprecipitation from fixed clinical tissues reveals t...
Published: April, 2016
Abstract: Extensive cross-linking introduced during routine tissue fixation of clinical pathology specimens severely hampers chromatin immunoprecipitation fo... Read more »
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Antibody
Parental epigenetic asymmetry of PRC2-mediated histone modification...
Published: April, 2016
Abstract: Parental genomes in the endosperm are marked by differential DNA methylation and are therefore epigenetically distinct. This epigenetic asymmetry i... Read more »
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Antibody IPure kit Microplex Library Preparation kit
EZH2 regulates neuroepithelium structure and neuroblast proliferati...
Published: April, 2016
Abstract: The function of EZH2 as a transcription repressor is well characterized. However, its role during vertebrate development is still poorly understood... Read more »
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Antibody
Active and Repressive Chromatin-Associated Proteome after MPA Treat...
Published: April, 2016
Abstract: Mycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However, gastrointestinal (GI) complications, particul... Read more »
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Antibody Histone ChIP kit Article alert

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