Publications,References

Gene mobility elements mediate cell type specific genome organizati...
Published: December, 2024

Abstract: Understanding the level of genome organization that governs gene regulation remains a challenge despite advancements in chromatin profiling techniq... Read more »

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NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive ge...
Published: November, 2024

Abstract: Highlights Degradation of NUP98-fp halts nascent transcription of key oncogenes within 1 h NUP98-fp loss results in accumulat... Read more »

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Antibody

HIRA protects telomeres against R-loop-induced instability in ALT c...
Published: November, 2024

Abstract: Highlights HIRA establishes greater telomeric chromatin accessibility after ATRX-DAXX loss Deposition of new H3.3 by HIRA-UBN r... Read more »

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Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor act...
Published: November, 2024

Abstract: Peroxiredoxin 1 (PRDX1), an intracellular antioxidant enzyme, has emerged as a regulator of inflammatory responses via Toll-like receptor 4 (TLR4) ... Read more »

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Antibody

Cells transit through a quiescent-like state to convert to neurons ...
Published: November, 2024

Abstract: While transcription factors (TFs) provide essential cues for directing and redirecting cell fate, TFs alone are insufficient to drive cells to adop... Read more »

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Enhancing single-cell ATAC sequencing with formaldehyde fixation, c...
Published: November, 2024

Abstract: The assay for transposase-accessible chromatin using sequencing (ATAC-seq) revolutionized the field of epigenetics since its emergence by providing... Read more »

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The Novel Direct AR Target Gene Annexin A2 Mediates Androgen-Induce...
Published: November, 2024

Abstract: Clinical trials for prostate cancer (PCa) patients have implemented the bipolar androgen therapy (BAT) that includes the treatment with supraphysio... Read more »

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iDeal ChIP-seq Kit for Transcription Factors

TEAD-targeting small molecules induce a cofactor switch to regulate...
Published: November, 2024

Abstract: TEAD proteins are the main transcriptional effectors of the Hippo signaling pathway and a pharmacological target in oncology. Most TEAD-targeting s... Read more »

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Microplex Library Preparation kit iDeal ChIP-seq Kit for Transcription Factors Chromatin Profiling (ChIP-seq) Services

Steroid receptor-assisted loading modulates transcriptional respons...
Published: November, 2024

Abstract: Steroid receptors are involved in a wide array of crosstalk mechanisms that regulate diverse biological processes, with significant implications in... Read more »

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Nuclear localization of MTHFD2 is required for correct mitosis prog...
Published: November, 2024

Abstract: Subcellular compartmentalization of metabolic enzymes establishes a unique metabolic environment that elicits specific cellular functions. Indeed, ... Read more »

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Antibody

Claudin-1 as a potential marker of stress-induced premature senesce...
Published: November, 2024

Abstract: Cellular senescence, a permanent state of cell cycle arrest, can result either from external stress and is then called stress-induced premature sen... Read more »

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Antibody iDeal ChIP-seq Kit for Histones

Engineered PsCas9 enables therapeutic genome editing in mouse liver...
Published: November, 2024

Abstract: Clinical implementation of therapeutic genome editing relies on efficient in vivo delivery and the safety of CRISPR-Cas tools. Previously, we ident... Read more »

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AistSeq: An In-House Tn5-Based Plasmid Sequencing Platform Using A ...
Published: November, 2024

Abstract: Sequence verification of plasmids is a fundamental process in synthetic biology. For plasmid sequence verification using next-generation sequencing... Read more »

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ACE2 Enhances Sensitivity to PD-L1 Blockade by Inhibiting Macrophag...
Published: November, 2024

Abstract: Anti-PD-L1-based combination immunotherapy has become the first-line treatment for unresectable hepatocellular carcinoma (HCC). However, the object... Read more »

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Microplex Library Preparation kit

The molecular consequences of FOXF1 missense mutations associated w...
Published: November, 2024

Abstract: Background Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a fatal congenital lung disorder strongly associated wit... Read more »

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CUT&Tag

Atypical chemokine receptor 2 expression is directly regulated by h...
Published: November, 2024

Abstract: Lack of significant and durable clinical benefit from anti-cancer immunotherapies is partly due to the failure of cytotoxic immune cells to infiltr... Read more »

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iDeal ChIP-qPCR

ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fa...
Published: November, 2024

Abstract: SREBF1 plays the central role in lipid metabolism. It has been known that full-length SREBF1 that did not associate with SCAP (SCAP-free SREBF1) is... Read more »

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Tagmentase

Histone variant H2BE controls activity-dependent gene expression an...
Published: November, 2024

Abstract: A cell’s ability to respond and adapt to environmental stimuli relies in part on transcriptional programs controlled by histone proteins. His... Read more »

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CUT&Tag

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T help...
Published: November, 2024

Abstract: While inputs regulating CD4+ T helper cell (Th) differentiation are well-defined, the integration of downstream signaling with transcriptional... Read more »

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CUT&Tag

Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticit...
Published: October, 2024

Abstract: Cancer cell plasticity contributes significantly to the failure of chemo- and targeted therapies in triple-negative breast cancer (TNBC). Molecular... Read more »

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iDeal ChIP-seq Kit for Transcription Factors

Inflammation impacts androgen receptor signaling in basal prostate ...
Published: October, 2024

Abstract: Chronic prostate inflammation in patients with benign prostate hyperplasia (BPH) correlates with the severity of symptoms. How inflammation contrib... Read more »

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CUT&Tag

A multidimensional recommendation framework for identifying biologi...
Published: October, 2024

Abstract: The quest to understand the molecular mechanisms of tumour metastasis and identify pivotal biomarkers for cancer therapy is increasing in importanc... Read more »

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Antibody

GTSF1 is required for transposon silencing in the unicellular eukar...
Published: October, 2024

Abstract: The PIWI-interacting RNA (piRNA) pathway is crucial for transposon repression and the maintenance of genomic integrity. Gametocyte-specific factor ... Read more »

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Antibody

On the identification of differentially-active transcription factor...
Published: October, 2024

Abstract: ATAC-seq has emerged as a rich epigenome profiling technique, and is commonly used to identify Transcription Factors (TFs) underlying given phenome... Read more »

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Tagmentase

Extracellular vesicle-mediated trafficking of molecular cues during...
Published: October, 2024

Abstract: Cellular crosstalk is an essential process influenced by numerous factors, including secreted vesicles that transfer nucleic acids, lipids, and pro... Read more »

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Microplex Library Preparation kit

COL25A1 and METAP1D DNA methylation are promising liquid biopsy epi...
Published: October, 2024

Abstract: Background Colorectal cancer is a public health issue and was the third leading cause of cancer-related death worldwide in 2022. Early diagnosis c... Read more »

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Premium Bisulfite Kit

Differential methylation of circulating free DNA assessed through c...
Published: October, 2024

Abstract: Background Recent studies have highlighted the importance of the cell-free DNA (cfDNA) methylation profile in detecting breast cancer (BC) and its... Read more »

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MagMeDIP kit

Dysregulation of pseudouridylation in small RNAs contributes to pap...
Published: October, 2024

Abstract: Background Previous studies have indicated that ψ-modified small RNAs play crucial roles in tumor metastasis. However, the ψ-modified smal... Read more »

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Antibody

Biochemical characterization of the feedforward loop between CDK1 a...
Published: October, 2024

Abstract: The complex network governing self-renewal in epidermal stem cells (EPSCs) is only partially defined. FOXM1 is one of the main players in this netw... Read more »

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iDeal ChIP-seq Kit for Transcription Factors

Rational design of peak calling parameters for TIP-seq based on pA-...
Published: October, 2024

Abstract: Epigenomic profiling provides insights into the regulatory mechanisms that govern gene expression. At a fundamental level, these mechanisms are det... Read more »

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