Publications,References

A transgenic mice model of retinopathy of cblG-type inherited disor...
Published: October, 2023

Abstract: BACKGROUND: MTR gene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-carbon metabolis... Read more »

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Newly added

G-quadruplexes of KSHV oriLyt play important roles in promoting lyt...
Published: October, 2023

Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes distinct origins of DNA replication (origin of replications) during the latent and lytic ph... Read more »

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ARID1A governs the silencing of sex-linked transcription during mal...
Published: September, 2023

Abstract: We present evidence implicating the BAF (BRG1/BRM Associated Factor) chromatin remodeler in meiotic sex chromosome inactivation (MSCI). By immunofl... Read more »

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Tagmentase

Knockout of the longevity gene Klotho perturbs aging- and Alzheimer...
Published: September, 2023

Abstract: Overexpression of the longevity gene Klotho prolongs, while its knockout shortens lifespan and impairs cognition via altered fibroblast growth fact... Read more »

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D-Plex small RNA-seq

A Type II-B Cas9 nuclease with minimized off-targets and reduced ch...
Published: September, 2023

Abstract: Streptococcus pyogenes Cas9 (SpCas9) and derived enzymes are widely used as genome editors, but their promiscuous nuclease activity often ... Read more »

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Tagmentase

Combined Analysis of mRNA Expression and Open Chromatin in Microglia
Published: August, 2023

Abstract: The advance of single-cell RNA-sequencing technologies in the past years has enabled unprecedented insights into the complexity and heterogeneity o... Read more »

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Tagmentase

Volumetric imaging of an intact organism by a distributed molecular...
Published: August, 2023

Abstract: Lymphatic, nervous, and tumoral tissues, among others, exhibit physiology that emerges from three-dimensional interactions between genetically uniq... Read more »

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Tagmentase

FACT regulates pluripotency through proximal and distal regulation ...
Published: August, 2023

Abstract: Background The FACT complex is a conserved histone chaperone with critical roles in transcription and histone deposition. FACT is essential in plu... Read more »

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FACT regulates pluripotency through proximal and distal regulation ...
Published: August, 2023

Abstract: Background The FACT complex is a conserved histone chaperone with critical roles in transcription and histone deposition. FACT is essential in plu... Read more »

Cerebrospinal fluid methylome-based liquid biopsies for accuratemal...
Published: August, 2023

Abstract: BACKGROUND: Resolving the differential diagnosis between brain metastases (BM), glioblastomas (GBM), and central nervous system lymphomas (CNSL) is... Read more »

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MagMeDIP kit IPure kit

Nuclear proinflammatory cytokine S100A9 enhances expression of huma...
Published: August, 2023

Abstract: Transcription of the human papillomavirus (HPV) oncogenes, and , is regulated by the long control region (LCR) of the viral genome. Although vario... Read more »

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A high-throughput screening assay for silencing established HIV-1 m...
Published: August, 2023

Abstract: HIV-infected macrophages are long-lived cells that represent a barrier to functional cure. Additionally, low-level viral expression by central nerv... Read more »

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Newly added

Transgenerational endocrine disruptor effects of cadmium in zebrafi...
Published: August, 2023

Abstract: Evidence has emerged that environmentally-induced epigenetic changes can have long-lasting effects on gene transcription across generations. These ... Read more »

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MagMeDIP kit

Transcription factor EGR2 controls homing and pathogenicity of T17c...
Published: August, 2023

Abstract: CD4 T helper 17 (T17) cells protect barrier tissues but also trigger autoimmunity. The mechanisms behind these opposing processes remain unclear. H... Read more »

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CUT&Tag

ThPOK is a critical multifaceted regulator of myeloid lineagedevelo...
Published: August, 2023

Abstract: The transcription factor ThPOK (encoded by Zbtb7b) is well known for its role as a master regulator of CD4 lineage commitment in the thymus. Here, ... Read more »

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Antibody iDeal ChIP-seq Kit for Transcription Factors

Differentiation block in acute myeloid leukemia regulated by intron...
Published: August, 2023

Abstract: Iroquois transcription factor gene IRX3 is highly expressed in 20â€“30\% of acute myeloid leukemia (AML) and contributes to the pa... Read more »

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MagMeDIP kit IPure kit Microplex Library Preparation kit ChIP Cross-link Gold

Zfp296 knockout enhances chromatin accessibility and induces a uniq...
Published: July, 2023

Abstract: The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse embryonic stem cells (ESCs) but rapidly decreases following dif... Read more »

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Perturbed epigenetic transcriptional regulation in AML with IDH mut...
Published: July, 2023

Abstract: Isocitrate dehydrogenase (IDH) mutations are found in 20\% of acute myeloid leukemia (AML) patients. However, only 30-40\% of the patients respond ... Read more »

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Newly added

Zfp296 knockout enhances chromatin accessibility and induces a uniq...
Published: July, 2023

Abstract: The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse embryonic stem cells (ESCs) but rapidly decreases following dif... Read more »

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Antibody Tagmentase

Mediator 1 ablation induces enamel-to-hair lineage conversion in mi...
Published: July, 2023

Abstract: Postnatal cell fate is postulated to be primarily determined by the local tissue microenvironment. Here, we find that Mediator 1 (Med1) dependent e... Read more »

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IPure kit iDeal ChIP-seq Kit for Transcription Factors

CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c inHCT116...
Published: July, 2023

Abstract: The miR-34a and miR-34b/c encoding genes represent direct targets of the p53 transcription factor, and presumably mediate part of the tumor suppres... Read more »

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iDeal ChIP-qPCR

Perturbed epigenetic transcriptional regulation in AML with IDHmuta...
Published: July, 2023

Abstract: Isocitrate dehydrogenase (IDH) mutations are found in 20\% of acute myeloid leukemia (AML) patients. However, only 30-40\% of the patients respond ... Read more »

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Infinium Human MethylationEPIC Array Service

Carnobacterium maltaromaticum boosts intestinal vitamin D productio...
Published: July, 2023

Abstract: Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C.Â&nb... Read more »

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Antibody

Enhanced frequency of transcription pre-initiation complexes assemb...
Published: July, 2023

Abstract: In addition to being essential for gene expression, transcription is crucial for the maintenance of genome integrity. Here, we undertook a systemat... Read more »

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Antibody

ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic ac...
Published: July, 2023

Abstract: Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) have been approved for both frontline and recurrent setting in ovarian cancer with homologou... Read more »

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Antibody

Opposing gene regulatory programs governing myofiber development an...
Published: July, 2023

Abstract: Skeletal muscle fibers express distinct gene programs during development and maturation, but the underlying gene regulatory networks that confer st... Read more »

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Antibody

Alterations in the hepatocyte epigenetic landscape in steatosis.
Published: July, 2023

Abstract: Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk f... Read more »

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Antibody

SMYD3 represses tumor-intrinsic interferon response in HPV-negative...
Published: July, 2023

Abstract: Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of immune escape in hu... Read more »

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Antibody

DeSUMOylation of chromatin-bound proteins limits the rapidtranscrip...
Published: July, 2023

Abstract: Genotoxicants have been used for decades as front-line therapies against cancer on the basis of their DNA-damaging actions. However, some of their ... Read more »

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Antibody

RNA polymerase II CTD is dispensable for transcription and required...
Published: July, 2023

Abstract: The largest subunit of RNA polymerase (Pol) II harbors an evolutionarily conserved C-terminal domain (CTD), composed of heptapeptide repeats, centr... Read more »

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Antibody

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