Publications,References

The histone H3K36 methyltransferase MES-4 acts epigenetically to tr...
Published: September, 2010

Abstract: Methylation of histone H3K36 in higher eukaryotes is mediated by multiple methyltransferases. Set2-related H3K36 methyltransferases are targeted to... Read more »

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Chromatin Shearing ChIP-qPCR

DNA methylation prevents CTCF-mediated silencing of the oncogene BC...
Published: August, 2010

Abstract: Aberrant DNA methylation commonly occurs in cancer cells where it has been implicated in the epigenetic silencing of tumor suppressor genes. Additi... Read more »

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DNA shearing Bioruptor Chromatin Shearing ChIP-qPCR

Iron regulatory proteins secure mitochondrial iron sufficiency and ...
Published: August, 2010

Abstract: Mitochondria supply cells with ATP, heme, and iron sulfur clusters (ISC), and mitochondrial energy metabolism involves both heme- and ISC-dependent... Read more »

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Bioruptor Cell Lysis

The distribution of active RNA polymerase II along the transcribed ...
Published: August, 2010

Abstract: In order to study the intragenic profiles of active transcription, we determined the relative levels of active RNA polymerase II present at the 3'-... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Genome-wide mapping of histone H4 serine-1 phosphorylation during s...
Published: August, 2010

Abstract: We previously showed that histone H4 serine-1 phosphorylation (H4S1ph) is evolutionarily conserved during gametogenesis, and contributes to post-me... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

Genome-wide profiling of p63 DNA-binding sites identifies an elemen...
Published: August, 2010

Abstract: Heterozygous mutations in p63 are associated with split hand/foot malformations (SHFM), orofacial clefting, and ectodermal abnormalities. Elucidati... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

The repressing function of the oncoprotein BCL-3 requires CtBP, whi...
Published: August, 2010

Abstract: The nuclear and oncogenic BCL-3 protein activates or represses gene transcription when bound to NF-kappaB proteins p50 and p52, yet the molecules t... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent ...
Published: August, 2010

Abstract: Pluripotent cells develop within the inner cell mass of blastocysts, a mosaic of cells surrounded by an extra-embryonic layer, the trophectoderm. W... Read more »

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Antibody

Differential regulation of HIC1 target genes by CtBP and NuRD, via ...
Published: August, 2010

Abstract: The tumor suppressor gene HIC1 encodes a transcriptional repressor involved in regulatory loops modulating P53-dependent and E2F1-dependent cell su... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

miR-192 mediates TGF-beta/Smad3-driven renal fibrosis.
Published: August, 2010

Abstract: TGF-beta/Smad3 promotes renal fibrosis, but the mechanisms that regulate profibrotic genes remain unclear. We hypothesized that miR-192, a microRNA... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

The down-regulation of the human MYC gene by the nuclear hormone 1a...
Published: July, 2010

Abstract: MYC is a pleiotropic transcription factor that coordinates the expression of diverse programs that are together necessary for the growth and expans... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Terminal osseous dysplasia is caused by a single recurrent mutation...
Published: July, 2010

Abstract: Terminal osseous dysplasia (TOD) is an X-linked dominant male-lethal disease characterized by skeletal dysplasia of the limbs, pigmentary defects o... Read more »

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DNA shearing Bioruptor

Conserved role of intragenic DNA methylation in regulating alternat...
Published: July, 2010

Abstract: Although it is known that the methylation of DNA in 5' promoters suppresses gene expression, the role of DNA methylation in gene bodies is unclear.... Read more »

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DNA shearing Bioruptor

The NoRC complex mediates the heterochromatin formation and stabili...
Published: July, 2010

Abstract: Maintenance of specific heterochromatic domains is crucial for genome stability. In eukaryotic cells, a fraction of the tandem-repeated ribosomal R... Read more »

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Antibody Master Mix

Novel trans-tail regulation of H2B ubiquitylation and H3K4 methylat...
Published: July, 2010

Abstract: Chromatin is regulated by cross talk among different histone modifications, which can occur between residues within the same tail or different tail... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Loss of Rb proteins causes genomic instability in the absence of mi...
Published: July, 2010

Abstract: Loss of G1/S control is a hallmark of cancer, and is often caused by inactivation of the retinoblastoma pathway. However, mouse embryonic fibroblas... Read more »

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DNA shearing Bioruptor

Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regula...
Published: July, 2010

Abstract: Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that facilitates the excretion of bile salt conjugates and othe... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

The impact of intragenic CpG content on gene expression.
Published: July, 2010

Abstract: The development of vaccine components or recombinant therapeutics critically depends on sustained expression of the corresponding transgene. This s... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Roles of COMM-domain-containing 1 in stability and recruitment of t...
Published: July, 2010

Abstract: A novel function of COMMD1 {COMM [copper metabolism MURR1 (mouse U2af1-rs1 region 1)]-domain-containing 1}, a protein relevant to canine copper tox... Read more »

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Cell Lysis

Use of Illumina sequencing to identify transposon insertions underl...
Published: July, 2010

Abstract: High-copy transposons have been effectively exploited as mutagens in a variety of organisms. However, their utility for phenotype-driven forward ge... Read more »

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DNA shearing Bioruptor

The HOX Code as a "biological fingerprint" to distinguish functiona...
Published: July, 2010

Abstract: Mesenchymal stem cells (MSC) have been isolated from almost every adult tissue. In cord blood (CB), different non-hematopoietic CD45-, CD34- adhere... Read more »

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MeDIP kit

The bHLH transcription factor POPEYE regulates response to iron def...
Published: July, 2010

Abstract: Global population increases and climate change underscore the need for better comprehension of how plants acquire and process nutrients such as iro... Read more »

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Bioruptor Chromatin Shearing

Genome-wide profiling of interleukin-4 and STAT6 transcription fact...
Published: June, 2010

Abstract: Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesi... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

A gene-specific requirement of RNA polymerase II CTD phosphorylatio...
Published: June, 2010

Abstract: BACKGROUND: The switch from cellular proliferation to differentiation occurs to a large extent through specific programs of gene expression. In fis... Read more »

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Bioruptor Chromatin Shearing

Vertebrate homologue of Drosophila GAGA factor.
Published: June, 2010

Abstract: Polycomb group (PcG) and trithorax group (trxG) proteins are chromatin-mediated regulators of a number of developmentally important genes including... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

A simple method for gene expression and chromatin profiling of indi...
Published: June, 2010

Abstract: Understanding the production and function of specialized cells during development requires the isolation of individual cell types for analysis, but... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Chromatin-Remodeling Components of the BAF Complex Facilitate Repro...
Published: June, 2010

Abstract: Reprogramming of somatic cells achieved by combination of the four transcription factors Oct4, Sox2, Klf4, and c-Myc has very low efficiency. To in... Read more »

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LowCell ChIP kit

Regulation of cyclin B2 expression and cell cycle G2/m transition b...
Published: June, 2010

Abstract: Multiple endocrine neoplasia type 1 (MEN1) results from mutations in tumor suppressor gene Men1, which encodes nuclear protein menin. Menin up-regu... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Th2 LCR is essential for regulation of Th2 cytokine genes and for p...
Published: June, 2010

Abstract: Previous studies have shown that Th2 cytokine genes on mouse chromosome 11 are coordinately regulated by the Th2 locus control region (LCR). To exa... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

ESCs require PRC2 to direct the successful reprogramming of differe...
Published: June, 2010

Abstract: Embryonic stem cells (ESCs) are pluripotent, self-renewing, and have the ability to reprogram differentiated cell types to pluripotency upon cellul... Read more »

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Antibody

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