Publications,References

Structure-guided mutational analysis reveals the functional require...
Published: November, 2014

Abstract: DOT1 enzymes are conserved methyltransferases that catalyse the methylation of lysine 79 on histone H3 (H3K79). Most eukaryotes contain one DOT1 en... Read more »

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Bioruptor Cell Lysis

Epigenetic Modification of Histone 3 Lysine 27: Mediator Subunit ME...
Published: November, 2014

Abstract: The Mediator complex is vital for the transcriptional regulation of eukaryotic genes. Mediator binds to nuclear receptors at target response elemen... Read more »

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Bioruptor Chromatin Shearing

Suppression of the FOXM1 transcriptional programme via novel small ...
Published: November, 2014

Abstract: The transcription factor FOXM1 binds to sequence-specific motifs on DNA (C/TAAACA) through its DNA-binding domain (DBD) and activates proliferation... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

HIV-1 Integrase Variants Retarget Viral Integration and Are Associa...
Published: November, 2014

Abstract: Distinct integration patterns of different retroviruses, including HIV-1, have puzzled virologists for over 20 years. A tetramer of the viral integ... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

Mating-type switching by chromosomal inversion in methylotrophic ye...
Published: November, 2014

Abstract: Saccharomyces cerevisiae has a complex system for switching the mating type of haploid cells, requiring the genome to have three mating-type (MAT)-... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Heavy transcription of yeast genes correlates with differential los...
Published: November, 2014

Abstract: Eukaryotic chromatin is composed of nucleosomes, which contain nearly two coils of DNA wrapped around a central histone octamer. The octamer contai... Read more »

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Bioruptor Chromatin Shearing ChIP-seq Bioruptor Plus

SNP-guided identification of monoallelic DNA-methylation events fro...
Published: November, 2014

Abstract: Monoallelic gene expression is typically initiated early in the development of an organism. Dysregulation of monoallelic gene expression has alread... Read more »

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MethylCap

Epigenetic modifications of gene promoter DNA in the liver of adult...
Published: November, 2014

Abstract: Testosterone (T) is known to masculinize the female phenotype of the liver, evidenced as up- and down-regulated expressions of male- and female-pre... Read more »

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MeDIP kit

Serine Deprivation Enhances Anti-neoplastic Activity of Biguanides.
Published: November, 2014

Abstract: Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits anti-neoplastic activity in experimental models and has b... Read more »

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Bioruptor Cell Lysis Mass Spectrometry

Combining MeDIP-seq and MRE-seq to investigate genome-wide CpG meth...
Published: November, 2014

Abstract: DNA CpG methylation is a widespread epigenetic mark in high eukaryotes including mammals. DNA methylation plays key roles in diverse biological pro... Read more »

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DNA shearing Bioruptor

Heterochromatin-mediated gene silencing facilitates the diversifica...
Published: November, 2014

Abstract: An astounding property of the nervous system is its cellular diversity. This diversity, which was initially realized by morphological and electroph... Read more »

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DNA shearing

DNA Copy-Number Control through Inhibition of Replication Fork Prog...
Published: November, 2014

Abstract: Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can dri... Read more »

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Bioruptor Chromatin Shearing ChIP-seq Bioruptor Plus

Silica nanoparticles induce autophagy and endothelial dysfunction v...
Published: November, 2014

Abstract: Although nanoparticles have a great potential for biomedical applications, there is still a lack of a correlative safety evaluation on the cardiova... Read more »

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Bioruptor

The repair of oxidized purines in the DNA of human lymphocytes requ...
Published: November, 2014

Abstract: 8-Oxoguanine DNA glycosylase (OGG1), which initiates the repair of DNA purine modifications such as 8-oxo-7,8-dihydroguanine (8-oxoG), is often reg... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR Bioruptor Plus

A phylogenomic analysis of turtles.
Published: November, 2014

Abstract: Molecular analyses of turtle relationships have overturned prevailing morphological hypotheses and prompted the development of a new taxonomy. Here... Read more »

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DNA shearing Bioruptor

The LXR-Idol Axis Differentially Regulates Plasma LDL Levels in Pri...
Published: November, 2014

Abstract: The LXR-regulated E3 ubiquitin ligase IDOL controls LDLR receptor stability independent of SREBP and PCSK9, but its relevance to plasma lipid level... Read more »

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Master Mix

A variably occupied CTCF binding site in the Ultrabithorax gene in ...
Published: November, 2014

Abstract: Although the majority of genomic binding sites for the insulator protein CTCF are constitutively occupied, a subset show variably occupancy. Such v... Read more »

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Bioruptor Chromatin Shearing

Detection of single nucleotide polymorphisms in Plasmodium falcipar...
Published: November, 2014

Abstract: Resistance of Plasmodium falciparum to some antimalarial drugs is linked to single nucleotide polymorphisms (SNPs). Currently there are no methods ... Read more »

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Bioruptor

Deregulation of Rb-E2F1 axis causes chromosomal instability by enga...
Published: November, 2014

Abstract: E2F family of transcription factors regulate genes involved in various aspects of cell cycle. Beyond the well-documented role in G1/S transition, m... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

A Novel Mouse Model for the Hyper-IgM Syndrome: A Spontaneous Activ...
Published: November, 2014

Abstract: We describe a spontaneously derived mouse line that completely failed to induce Ig class switching in vitro and in vivo. The mice inherited abolish... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR Bioruptor Plus

Continuous requirement for the TCR in regulatory T cell function.
Published: November, 2014

Abstract: Foxp3(+) regulatory T cells (Treg cells) maintain immunological tolerance, and their deficiency results in fatal multiorgan autoimmunity. Although ... Read more »

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Bioruptor

Genome-wide identification of signaling center enhancers in the dev...
Published: November, 2014

Abstract: The limb is widely used as a model developmental system and changes to gene expression patterns in its signaling centers, notably the zone of polar... Read more »

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LowCell ChIP kit

Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic R...
Published: November, 2014

Abstract: Increasing numbers of natural products have been found to possess anticancer effects. Nuclear factor erythroid-2-related factor-2 (Nrf2) is a maste... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Characterization of microsatellite markers for pinedrops, Pterospor...
Published: November, 2014

Abstract: UNLABELLED: • PREMISE OF THE STUDY: Pterospora andromedea (Ericaceae) is a mycoheterotrophic plant endemic to North America with a disjunct distrib... Read more »

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DNA shearing Bioruptor

RNA Processing Factors Swd2.2 and Sen1 Antagonize RNA Pol III-Depen...
Published: November, 2014

Abstract: Condensin-mediated chromosome condensation is essential for genome stability upon cell division. Genetic studies have indicated that the associatio... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Progestin and antiprogestin responsiveness in breast cancer is driv...
Published: November, 2014

Abstract: There is emerging interest in understanding the role of progesterone receptors (PRs) in breast cancer. The aim of this study was to investigate the... Read more »

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HighCell ChIP kit

Genome-wide identification of aberrantly methylated promoters in ov...
Published: November, 2014

Abstract: OBJECTIVE: To identify aberrantly methylated candidate genes that are involved in the development of polycystic ovary syndrome (PCOS). DESIGN: Anim... Read more »

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DNA shearing Bioruptor Antibody

Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B tran...
Published: November, 2014

Abstract: The Epstein-Barr virus (EBV) nuclear antigen 3 family of protein is critical for the EBV-induced primary B-cell growth transformation process. Usin... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Synthetic secondary chromosomes in Escherichia coli based on the re...
Published: October, 2014

Abstract: Recent developments in DNA-assembly methods make the synthesis of synthetic chromosomes a reachable goal. However, the redesign of primary chromoso... Read more »

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DNA shearing Bioruptor

IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi anemia cells ...
Published: October, 2014

Abstract: Fanconi anemia (FA) is a rare autosomal recessive genetic disorder associated with a bone-marrow failure, genome instability, hypersensitivity to D... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

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