Publications,References

Natural genetic variation impacts expression levels of coding, non-...
Published: November, 2014

Abstract: Our current understanding of how natural genetic variation affects gene expression beyond well-annotated coding genes is still limited. The use of ... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

Regulation of anti-sense transcription by Mot1p and NC2 via removal...
Published: November, 2014

Abstract: The activity and dynamic nature of TATA-binding protein (TBP) crucial to RNA polymerase II-mediated transcription is under control of the Mot1p and... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Long non-coding RNA-mediated transcriptional interference of a perm...
Published: November, 2014

Abstract: Most long non-coding RNAs (lncRNAs) encoded by eukaryotic genomes remain uncharacterized. Here we focus on a set of intergenic lncRNAs in fission y... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Epigenetic memory of the first cell fate decision prevents complete...
Published: November, 2014

Abstract: Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epig... Read more »

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DNA shearing Bioruptor

O-GlcNAcylation Prevents Aggregation of the Polycomb Group Represso...
Published: November, 2014

Abstract: The glycosyltransferase Ogt adds O-linked N-Acetylglucosamine (O-GlcNAc) moieties to nuclear and cytosolic proteins. Drosophila embryos lacking Ogt... Read more »

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Bioruptor Cell Lysis Western Blot

Cryptogenic stroke and small fiber neuropathy of unknown etiology i...
Published: November, 2014

Abstract: BackgroundFabry disease (FD) is a multisystemic disorder with typical neurological manifestations such as stroke and small fiber neuropathy (SFN), ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Synergistic template-free synthesis of dsDNA by Thermococcus nautil...
Published: November, 2014

Abstract: A combination of three enzymes from the hyperthermophilic archaeon Thermococcus nautili, DNA primase PolpTN2, DNA polymerase PolB, and pTN2 DNA hel... Read more »

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DNA shearing Bioruptor

MiR-98 delays skeletal muscle differentiation by downregulating E2F5.
Published: November, 2014

Abstract: A genome-wide screen had previously shown that knocking down miR-98 and let-7g, two miRNAs of the let-7 family, leads to a dramatic increase of ter... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesi...
Published: November, 2014

Abstract: Neuronal activity regulates the phosphorylation states at multiple sites on MeCP2 in postmitotic neurons. The precise control of the phosphorylatio... Read more »

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Bioruptor Cell Lysis

Regulatory network decoded from epigenomes of surface ectoderm-deri...
Published: November, 2014

Abstract: Developmental history shapes the epigenome and biological function of differentiated cells. Epigenomic patterns have been broadly attributed to the... Read more »

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DNA shearing Bioruptor

Single mutations in sasA enable a simpler ΔcikA gene network archit...
Published: November, 2014

Abstract: The circadian input kinase of the cyanobacterium Synechococcus elongatus PCC 7942 (CikA) is important both for synchronizing circadian rhythms with... Read more »

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DNA shearing Bioruptor

RNA helicase DDX21 coordinates transcription and ribosomal RNA proc...
Published: November, 2014

Abstract: DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle, but the molecular underpinnings of their involvement,... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR ChIP-seq

Concomitant downregulation of the imprinted genes DLK1 and MEG3 at ...
Published: November, 2014

Abstract: Background The two oppositely imprinted and expressed genes, DLK1 and MEG3, are located in the same gene cluster at 14q32. Previous studies in bla... Read more »

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True MicroChIP kit

Neuropeptide Y promotes adipogenesis in chicken adipose cells in vi...
Published: November, 2014

Abstract: Neuropeptide Y is an evolutionarily conserved neurotransmitter that stimulates food intake in higher vertebrate species and promotes adipogenesis i... Read more »

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Bioruptor Cell Lysis Enzymatic Assay Bioruptor Plus

Global methylation silencing of clustered proto-cadherin genes in c...
Published: November, 2014

Abstract: Epigenetic remodeling of cell adhesion genes is a common phenomenon in cancer invasion. This study aims to investigate global methylation of cell a... Read more »

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MeDIP kit

Circadian enhancers coordinate multiple phases of rhythmic gene tra...
Published: November, 2014

Abstract: Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models o... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

Identification by high-throughput imaging of the histone methyltran...
Published: November, 2014

Abstract: Recent evidence points to a role of chromatin in regulation of alternative pre-mRNA splicing (AS). In order to identify novel chromatin regulators ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Acute Depletion Redefines the Division of Labor among DNA Methyltra...
Published: November, 2014

Abstract: Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely ... Read more »

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Antibody 5mC (C15200081)

Diversification of bacterial genome content through distinct mechan...
Published: November, 2014

Abstract: Bacterial populations often consist of multiple co-circulating lineages. Determining how such population structures arise requires understanding wh... Read more »

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Megaruptor

Global quantitative proteomics reveals novel factors in the ecdyson...
Published: November, 2014

Abstract: The ecdysone signaling pathway plays a major role in various developmental transitions in insects. Recent advances in the understanding of ecdysone... Read more »

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Bioruptor Cell Lysis Mass Spectrometry

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in H...
Published: November, 2014

Abstract: A scarlet fever outbreak began in mainland China and Hong Kong in 2011 (refs. 1–6). Macrolide- and tetracycline-resistant Streptoco... Read more »

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Megaruptor

Identification of Cdca7 as a novel Notch transcriptional target inv...
Published: November, 2014

Abstract: Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated eleme... Read more »

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Bioruptor Chromatin Shearing

Protein arginine methyltransferase 5 is a key regulator of the MYCN...
Published: November, 2014

Abstract: Approximately half of poor prognosis neuroblastomas (NBs) are characterized by pathognomonic MYCN gene amplification and MYCN over-expression. Here... Read more »

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Bioruptor Cell Lysis

MicroRNAs 206 and 21 Cooperate To Promote RAS-Extracellular Signal-...
Published: November, 2014

Abstract: Despite the low prevalence of activating point mutation of RAS or RAF genes, the RAS-extracellular signal-regulated kinase (ERK) pathway is implica... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

The role of maternal-specific H3K9me3 modification in establishing ...
Published: November, 2014

Abstract: Maintaining a single active X-chromosome by repressing Xist is crucial for embryonic development in mice. Although the Xist activator RNF12/RLIM is... Read more »

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LowCell ChIP kit

Fission yeast Cactin restricts telomere transcription and elongatio...
Published: November, 2014

Abstract: The telomeric transcriptome comprises multiple long non-coding RNAs generated by transcription of linear chromosome ends. In a screening performed ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Inhibition of osteoclastogenesis and inflammatory bone resorption b...
Published: November, 2014

Abstract: Emerging evidence suggests that RANKL-induced changes in chromatin state are important for osteoclastogenesis, but these epigenetic mechanisms are ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Decoupling of evolutionary changes in transcription factor binding ...
Published: November, 2014

Abstract: To understand the evolutionary dynamics between transcription factor (TF) binding and gene expression in mammals, we compared transcriptional outpu... Read more »

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Bioruptor

Structure-guided mutational analysis reveals the functional require...
Published: November, 2014

Abstract: DOT1 enzymes are conserved methyltransferases that catalyse the methylation of lysine 79 on histone H3 (H3K79). Most eukaryotes contain one DOT1 en... Read more »

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Bioruptor Cell Lysis

Epigenetic Modification of Histone 3 Lysine 27: Mediator Subunit ME...
Published: November, 2014

Abstract: The Mediator complex is vital for the transcriptional regulation of eukaryotic genes. Mediator binds to nuclear receptors at target response elemen... Read more »

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Bioruptor Chromatin Shearing

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