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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Evidence for Epigenetic Regulation of Pro-Inflammatory Cytokines, I...
Published: November, 2015
Abstract: While Post Traumatic Stress Disorder (PTSD) is associated with immune dysfunction, the underlying mechanisms remain unclear. Studies suggest a role... Read more »
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MagMeDIP kit Article alert
Pyruvate kinase isoform switching and hepatic metabolic reprogrammi...
Published: November, 2015
Abstract: The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elicits dose-dependent hepatotoxicity that includes fat accumulation, infl... Read more »
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Microplex Library Preparation kit Article alert
Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses...
Published: November, 2015
Abstract: Oct-1 (POU2f1) and Oct-2 (POU2f2) are members of the POU family of transcription factors. They recognize the same DNA sequence but fulfil distinct ... Read more »
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Chromatin Shearing
Hepatic DNA hydroxymethylation is site-specifically altered by chro...
Published: November, 2015
Abstract: PURPOSE: Global DNA hydroxymethylation is markedly decreased in human cancers, including hepatocellular carcinoma, which is associated with chro... Read more »
Selective targeting of the BRG/PB1 bromodomains impairs embryonic a...
Published: November, 2015
Abstract: Mammalian SWI/SNF [also called Brg/Brahma-associated factors (BAFs)] are evolutionarily conserved chromatin-remodeling complexes regulating gene tr... Read more »
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Antibody
Occupancy of RNA Polymerase II Phosphorylated on Serine 5 (RNAP S5P...
Published: November, 2015
Abstract: Regulation of gene transcription in varicella-zoster virus (VZV), a ubiquitous human neurotropic alphaherpesvirus, requires coordinated binding of ... Read more »
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Antibody
Progressive Chromatin Condensation and H3K9 Methylation Regulate th...
Published: November, 2015
Abstract: Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes a... Read more »
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IP-Star Compact
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancer...
Published: November, 2015
Abstract: Histone H3K36 trimethylation (H3K36me3) is frequently lost in multiple cancer types, identifying it as an important therapeutic target. Here we ide... Read more »
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Antibody
Complete Genome Sequences of Four Escherichia coli ST95 Isolates fr...
Published: November, 2015
Abstract: Finished genome sequences are presented for four Escherichia coli strains isolated from bloodstream infections at San Francisco General Hospital. T... Read more »
CRISPR-Mediated Gene Targeting of Human Induced Pluripotent Stem Cells
Published: November, 2015
Abstract: CRISPR/Cas9 nuclease systems can create double-stranded DNA breaks at specific sequences to efficiently and precisely disrupt, excise, mutate, inse... Read more »
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Antibody
Cell-Cycle-Dependent Reconfiguration of the DNA Methylome during Te...
Published: November, 2015
Abstract: Molecular mechanisms underlying terminal differentiation of B cells into plasma cells are major determinants of adaptive immunity but remain only p... Read more »
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Antibody
The homeoprotein DLX3 and tumor suppressor p53 co-regulate cell cyc...
Published: November, 2015
Abstract: Epidermal homeostasis depends on the coordinated control of keratinocyte cell cycle. Differentiation and the alteration of this balance can result ... Read more »
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Antibody
Spatial Interplay between Polycomb and Trithorax Complexes Controls...
Published: November, 2015
Abstract: Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin modifying complexes, however, how they together me... Read more »
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Antibody
Sox4 Expression Confers Bladder Cancer Stem Cell Properties and Pre...
Published: November, 2015
Abstract: Genetic and epigenetic alterations have been identified as to contribute directly or indirectly to the generation of transitional cell carcinoma of... Read more »
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Antibody
HNF1β drives glutathione (GSH) synthesis underlying intrinsic carbo...
Published: October, 2015
Abstract: Chemoresistance to platinum-based antineoplastic agents is a consistent feature among ovarian carcinomas; however, whereas high-grade serous carcin... Read more »
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Bioruptor Article alert
NeuroD1 reprograms chromatin and transcription factor landscapes to...
Published: October, 2015
Abstract: Abstract Cell fate specification relies on the action of critical transcription factors that become available at distinct stages of embryonic deve... Read more »
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Bioruptor Chromatin Shearing Bioruptor Plus
Epigenetic role of CCAAT box-binding transcription factor NF-Y on I...
Published: October, 2015
Abstract: Nuclear factor Y (NF-Y) is a histone substitute protein that specifically binds to the CCAAT box of the target genes and thereby promotes their reg... Read more »
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Article alert
A gene expression signature identifying transient DNMT1 depletion a...
Published: October, 2015
Abstract: Many human tumors show aberrant activation of a group of germline-specific genes, termed cancer-germline (CG) genes, several of which appear to exe... Read more »
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Antibody Article alert
Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Do...
Published: October, 2015
Abstract: α-synuclein, a protein enriched in Lewy bodies and highly implicated in neurotoxicity in Parkinson's disease, is distributed both at nerve te... Read more »
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Antibody
Optimized method for methylated DNA immuno-precipitation
Published: October, 2015
Abstract: Methylated DNA immunoprecipitation (MeDIP) is one of the most widely used methods to evaluate DNA methylation on a whole genome scale, and involves... Read more »
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Antibody
Loss of EZH2 results in precocious mammary gland development and ac...
Published: October, 2015
Abstract: Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin through the transcription factors STAT5A and STAT... Read more »
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Antibody
A geminivirus-based guide RNA delivery system for CRISPR/Cas9 media...
Published: October, 2015
Abstract: CRISPR/Cas has emerged as potent genome editing technology and has successfully been applied in many organisms, including several plant species. Ho... Read more »
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Antibody CRISPR Cas9 (C15200203)
The genetic association of RUNX3 with ankylosing spondylitis can be...
Published: October, 2015
Abstract: The authors sought to identify the functional basis for the genetic association of single nucleotide polymorphisms (SNP), upstream of the RUNX3 pro... Read more »
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Antibody Article alert
VEGF-mediated cell survival in non-small-cell lung cancer: implicat...
Published: October, 2015
Abstract: AIMS: To evaluate the potential therapeutic utility of histone deacetylase inhibitors (HDACi) in targeting VEGF receptors in non-small-cell lung... Read more »
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Antibody
Loss of BAP1 function leads to EZH2-dependent transformation
Published: October, 2015
Abstract: The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from histone H2A lysine 119 (H2A... Read more »
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IP-Star Compact
ClpX stimulates the mitochondrial unfolded protein response (UPRmt)...
Published: October, 2015
Abstract: Proteostasis is crucial for life and maintained by cellular chaperones and proteases. One major mitochondrial protease is the ClpXP complex, which ... Read more »
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Antibody
Arabidopsis CMT3 activity is positively regulated by AtSIZ1-mediate...
Published: October, 2015
Abstract: The activities of mammalian DNA and histone methyltransferases are regulated by post-translational modifications such as phosphorylation and sumoyl... Read more »
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Antibody
∆ DNMT3B4-del Contributes to Aberrant DNA Methylation Patterns in L...
Published: October, 2015
Abstract: Aberrant DNA methylation is a hallmark of cancer but mechanisms contributing to the abnormality remain elusive. We have previously shown that ∆DNMT... Read more »
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MethylCap
Disruption of KMT2D perturbs germinal center B cell development and...
Published: October, 2015
Abstract: Mutations in the gene encoding the KMT2D (or MLL2) methyltransferase are highly recurrent and occur early during tumorigenesis in diffuse large B c... Read more »
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Antibody
Polycomb repressive complex PRC1 spatially constrains the mouse emb...
Published: October, 2015
Abstract: The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripotency by silencing lineage-specifying developmental regul... Read more »
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Antibody

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