Publications,References

Recessive mutations in a distal PTF1A enhancer cause isolated pancr...
Published: January, 2014

Abstract: The contribution of cis-regulatory mutations to human disease remains poorly understood. Whole-genome sequencing can identify all noncoding variant... Read more »

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DNA shearing Bioruptor

Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglom...
Published: January, 2014

Abstract: Meis homeodomain transcription factors control cell proliferation, cell fate specification and differentiation in development and disease. Previous... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR Bioruptor Plus

Regulation of the neuronal transcription factor NPAS4 by REST and m...
Published: January, 2014

Abstract: NPAS4 is a brain restricted, activity-induced transcription factor which regulates the expression of inhibitory synapse genes to control homeostati... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Human cytomegalovirus major immediate early 1 protein targets host ...
Published: January, 2014

Abstract: The 72-kDa immediate early 1 (IE1) protein encoded by human cytomegalovirus (hCMV) is a nuclearly localized promiscuous regulator of viral and cell... Read more »

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Bioruptor Chromatin Shearing

Large conserved domains of low DNA methylation maintained by Dnmt3a.
Published: January, 2014

Abstract: Gains and losses in DNA methylation are prominent features of mammalian cell types. To gain insight into the mechanisms that promote shifts in DNA ... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A...
Published: January, 2014

Abstract: CENP-A chromatin forms the foundation for kinetochore assembly. Replication-independent incorporation of CENP-A at centromeres depends on its chape... Read more »

Inactivating CUX1 mutations promote tumorigenesis.
Published: January, 2014

Abstract: A major challenge in cancer genetics is to determine which low-frequency somatic mutations are drivers of tumorigenesis. Here we interrogate the ge... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR Bioruptor Plus

Genome-wide methylation and gene expression changes in newborn rats...
Published: December, 2013

Abstract: A large body of evidence from human and animal studies demonstrates that the maternal diet during pregnancy can programme physiological and metabol... Read more »

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DNA shearing Bioruptor MethylCap

Molecular mechanisms of regulation and action of microRNA-199a in t...
Published: December, 2013

Abstract: MicroRNA-199a (miRNA-199a) has been shown to have comprehensive functions and behave differently in different systems and diseases. It is encoded b... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Anti-androgen resistance in prostate cancer cells chronically induc...
Published: December, 2013

Abstract: Chronic inflammation has been linked to cancer initiation and progression in a variety of tissues, yet the impact of acute and chronic inflammatory... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Novel CTCF binding at a site in exon1A of BCL6 is associated with a...
Published: December, 2013

Abstract: BCL6 is a zinc-finger transcriptional repressor, which is highly expressed in germinal centre B-cells and is essential for germinal centre formatio... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Rapid and pervasive changes in genome-wide enhancer usage during ma...
Published: December, 2013

Abstract: Enhancers are distal regulatory elements that can activate tissue-specific gene expression and are abundant throughout mammalian genomes. Although ... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

Prmt7 is dispensable in tissue culture models for adipogenic differ...
Published: December, 2013

Abstract: Protein arginine methylation is a common posttranslational modification that has been implicated in numerous biological processes including gene ex... Read more »

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Bioruptor Cell Lysis Western Blot

H19 lncRNA controls gene expression of the Imprinted Gene Network b...
Published: December, 2013

Abstract: The H19 gene controls the expression of several genes within the Imprinted Gene Network (IGN), involved in growth control of the embryo. However, t... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR Antibody HighCell ChIP kit RNA Shearing

Nfatc1 orchestrates aging in hair follicle stem cells.
Published: December, 2013

Abstract: Hair production is fueled by stem cells (SCs), which transition between cyclical bouts of rest and activity. Here, we explore why hair growth wanes... Read more »

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Bioruptor Chromatin Shearing ChIP-seq

Langerhans cells are generated by two distinct PU.1-dependent trans...
Published: December, 2013

Abstract: Langerhans cells (LCs) are the unique dendritic cells found in the epidermis. While a great deal of attention has focused on defining the developme... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

UTX coordinates steroid hormone-mediated autophagy and cell death.
Published: December, 2013

Abstract: Correct spatial and temporal induction of numerous cell type-specific genes during development requires regulated removal of the repressive histone... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Local depletion of DNA methylation identifies a repressive p53 regu...
Published: December, 2013

Abstract: Genome-scale mapping suggests that the function of DNA methylation varies with genomic context beyond transcriptional repression. However, the use ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

NCoR controls glioblastoma tumor cell characteristics.
Published: December, 2013

Abstract: BACKGROUND: We have previously shown that the transcriptional coregulator NCoR represses astrocytic differentiation of neural stem cells, suggestin... Read more »

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HighCell ChIP kit

miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in respo...
Published: December, 2013

Abstract: The tumour suppressor p53 is a crucial regulator of cell cycle arrest and apoptosis by acting as a transcription factor to regulate a variety of ge... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

p53 status determines the role of autophagy in pancreatic tumour de...
Published: December, 2013

Abstract: Macroautophagy (hereafter referred to as autophagy) is a process in which organelles termed autophagosomes deliver cytoplasmic constituents to lyso... Read more »

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Bioruptor

HDAC inhibitor confers radiosensitivity to prostate stem-like cells.
Published: December, 2013

Abstract: Background:Radiotherapy can be an effective treatment for prostate cancer, but radiorecurrent tumours do develop. Considering prostate cancer heter... Read more »

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Antibody

β-Globin cis-elements determine differential nuclear targeting thro...
Published: December, 2013

Abstract: Increasing evidence points to nuclear compartmentalization as a contributing mechanism for gene regulation, yet mechanisms for compartmentalization... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

The maize glossy13 gene, cloned via BSR-Seq and Seq-walking encodes...
Published: December, 2013

Abstract: Aerial plant surfaces are covered by epicuticular waxes that among other purposes serve to control water loss. Maize glossy mutants originally iden... Read more »

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DNA shearing Bioruptor

Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an...
Published: December, 2013

Abstract: Activating K-Ras mutations and inactivating mutations of Smad4 are two common genetic alterations that occur in the development and progression of ... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Reprogramming of lysosomal gene expression by interleukin-4 and Stat6
Published: December, 2013

Abstract: Background Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coord... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR Master Mix

The role of Ctk1 kinase in termination of small non-coding RNAs.
Published: December, 2013

Abstract: Transcription termination in Saccharomyces cerevisiae can be performed by at least two distinct pathways and is influenced by the phosphorylation s... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

Transcriptional activation of Mina by Sp1/3 factors.
Published: December, 2013

Abstract: Mina is an epigenetic gene regulatory protein known to function in multiple physiological and pathological contexts, including pulmonary inflammati... Read more »

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Bioruptor Chromatin Shearing ChIP-qPCR

The Emerging Role of SOX2 in Cell Proliferation and Survival and It...
Published: December, 2013

Abstract: Tumor cells have long been observed to share several biological characteristics with normal stem/progenitor cells; however, the oncogenic mechanism... Read more »

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LowCell ChIP kit

ZRF1 controls the retinoic acid pathway and regulates leukemogenic ...
Published: December, 2013

Abstract: Acute myeloid leukemia (AML) is frequently linked to epigenetic abnormalities and deregulation of gene transcription, which lead to aberrant cell p... Read more »

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Bioruptor Cell Lysis Antibody

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